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Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

CKS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name:
CKS-2
Gene namesi
Name:CKS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 8

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 2PRO_0000260447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ2KJI1.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002522.

Structurei

3D structure databases

ProteinModelPortaliQ2KJI1.
SMRiQ2KJI1. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiNOG272189.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiQ2KJI1.
KOiK02219.
OMAiFDDKFEY.
OrthoDBiEOG735413.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKDQQK
Length:79
Mass (Da):9,860
Last modified:March 7, 2006 - v1
Checksum:i811B5927691EEC5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105331 mRNA. Translation: AAI05332.1.
RefSeqiNP_001106790.1. NM_001113319.2.
UniGeneiBt.13573.

Genome annotation databases

EnsembliENSBTAT00000002522; ENSBTAP00000002522; ENSBTAG00000001938.
GeneIDi767985.
KEGGibta:767985.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105331 mRNA. Translation: AAI05332.1.
RefSeqiNP_001106790.1. NM_001113319.2.
UniGeneiBt.13573.

3D structure databases

ProteinModelPortaliQ2KJI1.
SMRiQ2KJI1. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002522.

Proteomic databases

PRIDEiQ2KJI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002522; ENSBTAP00000002522; ENSBTAG00000001938.
GeneIDi767985.
KEGGibta:767985.

Organism-specific databases

CTDi1164.

Phylogenomic databases

eggNOGiNOG272189.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiQ2KJI1.
KOiK02219.
OMAiFDDKFEY.
OrthoDBiEOG735413.
TreeFamiTF101142.

Miscellaneous databases

NextBioi20918340.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCKS2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 7, 2006
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.