ID   AL9A1_BOVIN             Reviewed;         494 AA.
AC   Q2KJH9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=4-trimethylaminobutyraldehyde dehydrogenase;
DE            Short=TMABADH;
DE            EC=1.2.1.47;
DE   AltName: Full=Aldehyde dehydrogenase family 9 member A1;
DE            EC=1.2.1.3;
GN   Name=ALDH9A1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts gamma-trimethylaminobutyraldehyde into gamma-
CC       butyrobetaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4-trimethylammoniobutanal + NAD(+) + H(2)O =
CC       4-trimethylammoniobutanoate + NADH.
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; BC105335; AAI05336.1; -; mRNA.
DR   IPI; IPI00703131; -.
DR   RefSeq; NP_001039888.1; -.
DR   UniGene; Bt.16137; -.
DR   SMR; Q2KJH9; 2-494.
DR   Ensembl; ENSBTAG00000017852; Bos taurus.
DR   GeneID; 537539; -.
DR   KEGG; bta:537539; -.
DR   HOVERGEN; Q2KJH9; -.
DR   BRENDA; 1.2.1.3; 251.
DR   BRENDA; 1.2.1.47; 251.
DR   GO; GO:0047105; F:4-trimethylammoniobutyraldehyde dehydrogena...; IEA:EC.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; ISS:AgBase.
DR   GO; GO:0019145; F:aminobutyraldehyde dehydrogenase activity; ISS:AgBase.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:AgBase.
DR   GO; GO:0042136; P:neurotransmitter biosynthetic process; ISS:AgBase.
DR   GO; GO:0055114; P:oxidation reduction; ISS:AgBase.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; NAD; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    494       4-trimethylaminobutyraldehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000236270.
FT   NP_BIND     232    237       NAD (By similarity).
FT   ACT_SITE    254    254       Potential.
FT   ACT_SITE    288    288       Potential.
FT   MOD_RES       2      2       N-acetylserine (By similarity).
SQ   SEQUENCE   494 AA;  53977 MW;  74476EDC839F3241 CRC64;
     MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPASGRVI ATFTCSGEKE VNLAVQDAKA
     AFKIWSQKSG MERCRILLEA ARIIRERRDE IATMETINNG KSIFEARWDI DTSWQCLEYY
     AGLAGSMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMVFK
     PSPFTPVSVL LLAEIYTEAG VPPGLFNVVQ GGAATGQFLC QHRDVAKVSF TGSVPTGSKI
     MEMSAKGIKP VTLELGGKSP LIIFSDCDMK NAVKGALMAN FLTQGEVCCN GTRVFVQKEI
     LDQFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG AKVLCGGDVF
     VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL SFDTEAEVLE RANDTTFGLA
     AGVFTRDIQR AHRVVAELQA GMCFINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL
     KTVCVEMGDV ESAF
//