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Q2KJH9

- AL9A1_BOVIN

UniProt

Q2KJH9 - AL9A1_BOVIN

Protein

4-trimethylaminobutyraldehyde dehydrogenase

Gene

ALDH9A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine.By similarity

    Catalytic activityi

    4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.
    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei254 – 2541Sequence Analysis
    Active sitei288 – 2881Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi232 – 2376NADBy similarity

    GO - Molecular functioni

    1. 4-trimethylammoniobutyraldehyde dehydrogenase activity Source: UniProtKB-EC
    2. aldehyde dehydrogenase (NAD) activity Source: AgBase
    3. aminobutyraldehyde dehydrogenase activity Source: AgBase

    GO - Biological processi

    1. carnitine biosynthetic process Source: UniProtKB-UniPathway
    2. cellular aldehyde metabolic process Source: AgBase
    3. neurotransmitter biosynthetic process Source: AgBase
    4. oxidation-reduction process Source: AgBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00118.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-trimethylaminobutyraldehyde dehydrogenase (EC:1.2.1.47)
    Short name:
    TMABADH
    Alternative name(s):
    Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
    Gene namesi
    Name:ALDH9A1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 4944934-trimethylaminobutyraldehyde dehydrogenasePRO_0000236270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei30 – 301N6-acetyllysine; alternateBy similarity
    Modified residuei30 – 301N6-succinyllysine; alternateBy similarity
    Modified residuei59 – 591N6-succinyllysineBy similarity
    Modified residuei298 – 2981N6-acetyllysineBy similarity
    Modified residuei344 – 3441N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ2KJH9.
    PRIDEiQ2KJH9.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000033996.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJH9.
    SMRiQ2KJH9. Positions 2-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ2KJH9.
    KOiK00149.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2KJH9-1 [UniParc]FASTAAdd to Basket

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    MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPASGRVI ATFTCSGEKE    50
    VNLAVQDAKA AFKIWSQKSG MERCRILLEA ARIIRERRDE IATMETINNG 100
    KSIFEARWDI DTSWQCLEYY AGLAGSMAGE HIQLPGGSFG YTRREPLGVC 150
    VGIGAWNYPF QIACWKSAPA LACGNAMVFK PSPFTPVSVL LLAEIYTEAG 200
    VPPGLFNVVQ GGAATGQFLC QHRDVAKVSF TGSVPTGSKI MEMSAKGIKP 250
    VTLELGGKSP LIIFSDCDMK NAVKGALMAN FLTQGEVCCN GTRVFVQKEI 300
    LDQFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG 350
    AKVLCGGDVF VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL 400
    SFDTEAEVLE RANDTTFGLA AGVFTRDIQR AHRVVAELQA GMCFINNYNV 450
    SPVELPFGGY KKSGFGRENG RVTIEYYSQL KTVCVEMGDV ESAF 494
    Length:494
    Mass (Da):53,977
    Last modified:March 7, 2006 - v1
    Checksum:i74476EDC839F3241
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105335 mRNA. Translation: AAI05336.1.
    RefSeqiNP_001039888.1. NM_001046423.1.
    UniGeneiBt.16137.

    Genome annotation databases

    GeneIDi537539.
    KEGGibta:537539.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105335 mRNA. Translation: AAI05336.1 .
    RefSeqi NP_001039888.1. NM_001046423.1.
    UniGenei Bt.16137.

    3D structure databases

    ProteinModelPortali Q2KJH9.
    SMRi Q2KJH9. Positions 2-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000033996.

    Proteomic databases

    PaxDbi Q2KJH9.
    PRIDEi Q2KJH9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 537539.
    KEGGi bta:537539.

    Organism-specific databases

    CTDi 223.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi Q2KJH9.
    KOi K00149.

    Enzyme and pathway databases

    UniPathwayi UPA00118 .

    Miscellaneous databases

    NextBioi 20877155.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiAL9A1_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3