SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2KJH9

- AL9A1_BOVIN

UniProt

Q2KJH9 - AL9A1_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
4-trimethylaminobutyraldehyde dehydrogenase
Gene
ALDH9A1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.

Catalytic activityi

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei254 – 2541 Reviewed prediction
Active sitei288 – 2881 Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi232 – 2376NAD By similarity

GO - Molecular functioni

  1. 4-trimethylammoniobutyraldehyde dehydrogenase activity Source: UniProtKB-EC
  2. aldehyde dehydrogenase (NAD) activity Source: AgBase
  3. aminobutyraldehyde dehydrogenase activity Source: AgBase

GO - Biological processi

  1. carnitine biosynthetic process Source: UniProtKB-UniPathway
  2. cellular aldehyde metabolic process Source: AgBase
  3. neurotransmitter biosynthetic process Source: AgBase
  4. oxidation-reduction process Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00118.

Names & Taxonomyi

Protein namesi
Recommended name:
4-trimethylaminobutyraldehyde dehydrogenase (EC:1.2.1.47)
Short name:
TMABADH
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:ALDH9A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 4944934-trimethylaminobutyraldehyde dehydrogenase
PRO_0000236270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei30 – 301N6-acetyllysine; alternate By similarity
Modified residuei30 – 301N6-succinyllysine; alternate By similarity
Modified residuei59 – 591N6-succinyllysine By similarity
Modified residuei298 – 2981N6-acetyllysine By similarity
Modified residuei344 – 3441N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KJH9.
PRIDEiQ2KJH9.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033996.

Structurei

3D structure databases

ProteinModelPortaliQ2KJH9.
SMRiQ2KJH9. Positions 2-492.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ2KJH9.
KOiK00149.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJH9-1 [UniParc]FASTAAdd to Basket

« Hide

MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPASGRVI ATFTCSGEKE    50
VNLAVQDAKA AFKIWSQKSG MERCRILLEA ARIIRERRDE IATMETINNG 100
KSIFEARWDI DTSWQCLEYY AGLAGSMAGE HIQLPGGSFG YTRREPLGVC 150
VGIGAWNYPF QIACWKSAPA LACGNAMVFK PSPFTPVSVL LLAEIYTEAG 200
VPPGLFNVVQ GGAATGQFLC QHRDVAKVSF TGSVPTGSKI MEMSAKGIKP 250
VTLELGGKSP LIIFSDCDMK NAVKGALMAN FLTQGEVCCN GTRVFVQKEI 300
LDQFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG 350
AKVLCGGDVF VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL 400
SFDTEAEVLE RANDTTFGLA AGVFTRDIQR AHRVVAELQA GMCFINNYNV 450
SPVELPFGGY KKSGFGRENG RVTIEYYSQL KTVCVEMGDV ESAF 494
Length:494
Mass (Da):53,977
Last modified:March 7, 2006 - v1
Checksum:i74476EDC839F3241
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105335 mRNA. Translation: AAI05336.1.
RefSeqiNP_001039888.1. NM_001046423.1.
UniGeneiBt.16137.

Genome annotation databases

GeneIDi537539.
KEGGibta:537539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105335 mRNA. Translation: AAI05336.1 .
RefSeqi NP_001039888.1. NM_001046423.1.
UniGenei Bt.16137.

3D structure databases

ProteinModelPortali Q2KJH9.
SMRi Q2KJH9. Positions 2-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000033996.

Proteomic databases

PaxDbi Q2KJH9.
PRIDEi Q2KJH9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 537539.
KEGGi bta:537539.

Organism-specific databases

CTDi 223.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi Q2KJH9.
KOi K00149.

Enzyme and pathway databases

UniPathwayi UPA00118 .

Miscellaneous databases

NextBioi 20877155.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiAL9A1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi