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Q2KJH9 (AL9A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-trimethylaminobutyraldehyde dehydrogenase

Short name=TMABADH
EC=1.2.1.47
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1
EC=1.2.1.3
Gene names
Name:ALDH9A1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine By similarity.

Catalytic activity

4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH.

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Amine and polyamine biosynthesis; carnitine biosynthesis.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 4944934-trimethylaminobutyraldehyde dehydrogenase
PRO_0000236270

Regions

Nucleotide binding232 – 2376NAD By similarity

Sites

Active site2541 Potential
Active site2881 Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue301N6-acetyllysine; alternate By similarity
Modified residue301N6-succinyllysine; alternate By similarity
Modified residue591N6-succinyllysine By similarity
Modified residue2981N6-acetyllysine By similarity
Modified residue3441N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KJH9 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 74476EDC839F3241

FASTA49453,977
        10         20         30         40         50         60 
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPASGRVI ATFTCSGEKE VNLAVQDAKA 

        70         80         90        100        110        120 
AFKIWSQKSG MERCRILLEA ARIIRERRDE IATMETINNG KSIFEARWDI DTSWQCLEYY 

       130        140        150        160        170        180 
AGLAGSMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMVFK 

       190        200        210        220        230        240 
PSPFTPVSVL LLAEIYTEAG VPPGLFNVVQ GGAATGQFLC QHRDVAKVSF TGSVPTGSKI 

       250        260        270        280        290        300 
MEMSAKGIKP VTLELGGKSP LIIFSDCDMK NAVKGALMAN FLTQGEVCCN GTRVFVQKEI 

       310        320        330        340        350        360 
LDQFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG AKVLCGGDVF 

       370        380        390        400        410        420 
VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL SFDTEAEVLE RANDTTFGLA 

       430        440        450        460        470        480 
AGVFTRDIQR AHRVVAELQA GMCFINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 

       490 
KTVCVEMGDV ESAF 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC105335 mRNA. Translation: AAI05336.1.
RefSeqNP_001039888.1. NM_001046423.1.
UniGeneBt.16137.

3D structure databases

ProteinModelPortalQ2KJH9.
SMRQ2KJH9. Positions 2-492.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000033996.

Proteomic databases

PaxDbQ2KJH9.
PRIDEQ2KJH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID537539.
KEGGbta:537539.

Organism-specific databases

CTD223.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
HOVERGENHBG000097.
InParanoidQ2KJH9.
KOK00149.

Enzyme and pathway databases

UniPathwayUPA00118.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20877155.

Entry information

Entry nameAL9A1_BOVIN
AccessionPrimary (citable) accession number: Q2KJH9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways