Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serpin H1

Gene

SERPINH1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei377 – 378Reactive bond homologBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-BTA-1650814. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

MEROPSiI04.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000025360419 – 418Serpin H1Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-succinyllysineBy similarity1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei141PhosphoserineBy similarity1
Modified residuei207N6-acetyllysineBy similarity1
Modified residuei296N6-succinyllysineBy similarity1
Modified residuei319N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2KJH6.
PeptideAtlasiQ2KJH6.
PRIDEiQ2KJH6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001027.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039506.

Structurei

3D structure databases

ProteinModelPortaliQ2KJH6.
SMRiQ2KJH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi415 – 418Prevents secretion from ERPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 29Poly-Ala5

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00890000139355.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiQ2KJH6.
KOiK09501.
OMAiNYEHSKI.
OrthoDBiEOG091G08O0.
TreeFamiTF343094.

Family and domain databases

CDDicd02046. hsp47. 1 hit.
InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR033830. Serpin_H1_domain.
IPR033547. SERPINH1.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF220. PTHR11461:SF220. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALLLISTI CLLARALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL
60 70 80 90 100
AFSLYQAMAK DQAVENILLS PVVVASSLGL VSLGGKAATA SQAKAVLSAE
110 120 130 140 150
QLRDDEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFAEDFVRSS
160 170 180 190 200
KQHYNCEHSK INFRDKRSAL QSINEWAAQT TDGKLPEVTK DVERTDGALL
210 220 230 240 250
VNAMFFKPHW DERFHHKMVD NRGFMVTRSY TVGVTMMHRT GLYNYYDDEK
260 270 280 290 300
EKLQMVEMPL AHKLSSLIII MPHHVEPLER LEKLLTKEQL KVWMGKMQKK
310 320 330 340 350
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS
360 370 380 390 400
VFHATAFEWD TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL
410
LFIGRLVRPK GDKMRDEL
Length:418
Mass (Da):46,507
Last modified:March 7, 2006 - v1
Checksum:iDE81C53C711EF152
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105338 mRNA. Translation: AAI05339.1.
RefSeqiNP_001039528.1. NM_001046063.1.
XP_005216304.1. XM_005216247.2.
XP_005216305.1. XM_005216248.3.
UniGeneiBt.21385.

Genome annotation databases

EnsembliENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027.
GeneIDi510850.
KEGGibta:510850.

Similar proteinsi

Entry informationi

Entry nameiSERPH_BOVIN
AccessioniPrimary (citable) accession number: Q2KJH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 7, 2006
Last modified: August 30, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families