Q2KJH6 (SERPH_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin H1

Alternative name(s):
Collagen-binding protein
Short name=Colligin

Gene names

Name:

SERPINH1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Chaperone
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	collagen biosynthetic process Inferred from electronic annotation. Source: Compara collagen fibril organization Inferred from electronic annotation. Source: Compara protein maturation Inferred from electronic annotation. Source: Compara regulation of proteolysis Inferred from sequence or structural similarity. Source: RefGenome
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: RefGenome endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum-Golgi intermediate compartment Inferred from electronic annotation. Source: Compara
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from sequence or structural similarity. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 418	400	Serpin H1		PRO_0000253604
Regions
	Motif	415 – 418	4	Prevents secretion from ER Potential
	Compositional bias	25 – 29	5	Poly-Ala
Sites
	Site	377 – 378	2	Reactive bond homolog By similarity
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	125	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2KJH6 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: DE81C53C711EF152	FASTA	418	46,507
	10 20 30 40 50 60 MRALLLISTI CLLARALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 70 80 90 100 110 120 DQAVENILLS PVVVASSLGL VSLGGKAATA SQAKAVLSAE QLRDDEVHAG LGELLRSLSN 130 140 150 160 170 180 STARNVTWKL GSRLYGPSSV SFAEDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 190 200 210 220 230 240 TDGKLPEVTK DVERTDGALL VNAMFFKPHW DERFHHKMVD NRGFMVTRSY TVGVTMMHRT 250 260 270 280 290 300 GLYNYYDDEK EKLQMVEMPL AHKLSSLIII MPHHVEPLER LEKLLTKEQL KVWMGKMQKK 310 320 330 340 350 360 AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFEWD 370 380 390 400 410 TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105338 mRNA. Translation: AAI05339.1.
IPI	IPI00694938.
RefSeq	NP_001039528.1. NM_001046063.1.
UniGene	Bt.21385.
3D structure databases
ProteinModelPortal	Q2KJH6.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000039506.
Protein family/group databases
MEROPS	I04.036.
Proteomic databases
PaxDb	Q2KJH6.
PRIDE	Q2KJH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027.
GeneID	510850.
KEGG	bta:510850.
Organism-specific databases
CTD	871.
Phylogenomic databases
eggNOG	COG4826.
GeneTree	ENSGT00560000076649.
HOGENOM	HOG000238519.
HOVERGEN	HBG104930.
InParanoid	Q2KJH6.
KO	K09501.
OMA	INEWASQ.
OrthoDB	EOG43FGX2.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20869650.

Entry information

Entry name

SERPH_BOVIN

Accession

Primary (citable) accession number: Q2KJH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	March 7, 2006
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program