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Q2KJH6

- SERPH_BOVIN

UniProt

Q2KJH6 - SERPH_BOVIN

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Protein

Serpin H1

Gene

SERPINH1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei377 – 3782Reactive bond homologBy similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. chondrocyte development involved in endochondral bone morphogenesis Source: Ensembl
  2. collagen biosynthetic process Source: Ensembl
  3. collagen fibril organization Source: Ensembl
  4. negative regulation of endopeptidase activity Source: RefGenome
  5. protein maturation Source: Ensembl
  6. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_215758. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

MEROPSiI04.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 15

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  4. extracellular space Source: InterPro
  5. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 418400Serpin H1PRO_0000253604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-succinyllysineBy similarity
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Modified residuei207 – 2071N6-acetyllysineBy similarity
Modified residuei296 – 2961N6-succinyllysineBy similarity
Modified residuei319 – 3191N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ2KJH6.
PRIDEiQ2KJH6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039506.

Structurei

3D structure databases

ProteinModelPortaliQ2KJH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi415 – 4184Prevents secretion from ERPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 295Poly-Ala

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiQ2KJH6.
KOiK09501.
OMAiGVPMMHR.
OrthoDBiEOG7GBFX4.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRALLLISTI CLLARALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL
60 70 80 90 100
AFSLYQAMAK DQAVENILLS PVVVASSLGL VSLGGKAATA SQAKAVLSAE
110 120 130 140 150
QLRDDEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFAEDFVRSS
160 170 180 190 200
KQHYNCEHSK INFRDKRSAL QSINEWAAQT TDGKLPEVTK DVERTDGALL
210 220 230 240 250
VNAMFFKPHW DERFHHKMVD NRGFMVTRSY TVGVTMMHRT GLYNYYDDEK
260 270 280 290 300
EKLQMVEMPL AHKLSSLIII MPHHVEPLER LEKLLTKEQL KVWMGKMQKK
310 320 330 340 350
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS
360 370 380 390 400
VFHATAFEWD TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL
410
LFIGRLVRPK GDKMRDEL
Length:418
Mass (Da):46,507
Last modified:March 7, 2006 - v1
Checksum:iDE81C53C711EF152
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105338 mRNA. Translation: AAI05339.1.
RefSeqiNP_001039528.1. NM_001046063.1.
XP_005216304.1. XM_005216247.1.
XP_005216305.1. XM_005216248.1.
UniGeneiBt.21385.

Genome annotation databases

EnsembliENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027.
GeneIDi510850.
KEGGibta:510850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105338 mRNA. Translation: AAI05339.1 .
RefSeqi NP_001039528.1. NM_001046063.1.
XP_005216304.1. XM_005216247.1.
XP_005216305.1. XM_005216248.1.
UniGenei Bt.21385.

3D structure databases

ProteinModelPortali Q2KJH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000039506.

Protein family/group databases

MEROPSi I04.036.

Proteomic databases

PaxDbi Q2KJH6.
PRIDEi Q2KJH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000039717 ; ENSBTAP00000039506 ; ENSBTAG00000001027 .
GeneIDi 510850.
KEGGi bta:510850.

Organism-specific databases

CTDi 871.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118839.
HOGENOMi HOG000238519.
HOVERGENi HBG104930.
InParanoidi Q2KJH6.
KOi K09501.
OMAi GVPMMHR.
OrthoDBi EOG7GBFX4.
TreeFami TF343094.

Enzyme and pathway databases

Reactomei REACT_215758. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi 20869650.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiSERPH_BOVIN
AccessioniPrimary (citable) accession number: Q2KJH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3