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Protein

Serpin H1

Gene

SERPINH1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei377 – 3782Reactive bond homologBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_305967. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

MEROPSiI04.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 15

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 418400Serpin H1PRO_0000253604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-succinyllysineBy similarity
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Modified residuei207 – 2071N6-acetyllysineBy similarity
Modified residuei296 – 2961N6-succinyllysineBy similarity
Modified residuei319 – 3191N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ2KJH6.
PRIDEiQ2KJH6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039506.

Structurei

3D structure databases

ProteinModelPortaliQ2KJH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi415 – 4184Prevents secretion from ERPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 295Poly-Ala

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00770000120524.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiQ2KJH6.
KOiK09501.
OMAiNYEHSKI.
OrthoDBiEOG7GBFX4.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALLLISTI CLLARALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL
60 70 80 90 100
AFSLYQAMAK DQAVENILLS PVVVASSLGL VSLGGKAATA SQAKAVLSAE
110 120 130 140 150
QLRDDEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFAEDFVRSS
160 170 180 190 200
KQHYNCEHSK INFRDKRSAL QSINEWAAQT TDGKLPEVTK DVERTDGALL
210 220 230 240 250
VNAMFFKPHW DERFHHKMVD NRGFMVTRSY TVGVTMMHRT GLYNYYDDEK
260 270 280 290 300
EKLQMVEMPL AHKLSSLIII MPHHVEPLER LEKLLTKEQL KVWMGKMQKK
310 320 330 340 350
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS
360 370 380 390 400
VFHATAFEWD TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL
410
LFIGRLVRPK GDKMRDEL
Length:418
Mass (Da):46,507
Last modified:March 7, 2006 - v1
Checksum:iDE81C53C711EF152
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105338 mRNA. Translation: AAI05339.1.
RefSeqiNP_001039528.1. NM_001046063.1.
XP_005216304.1. XM_005216247.1.
XP_005216305.1. XM_005216248.2.
UniGeneiBt.21385.

Genome annotation databases

EnsembliENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027.
GeneIDi510850.
KEGGibta:510850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105338 mRNA. Translation: AAI05339.1.
RefSeqiNP_001039528.1. NM_001046063.1.
XP_005216304.1. XM_005216247.1.
XP_005216305.1. XM_005216248.2.
UniGeneiBt.21385.

3D structure databases

ProteinModelPortaliQ2KJH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039506.

Protein family/group databases

MEROPSiI04.036.

Proteomic databases

PaxDbiQ2KJH6.
PRIDEiQ2KJH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027.
GeneIDi510850.
KEGGibta:510850.

Organism-specific databases

CTDi871.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00770000120524.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiQ2KJH6.
KOiK09501.
OMAiNYEHSKI.
OrthoDBiEOG7GBFX4.
TreeFamiTF343094.

Enzyme and pathway databases

ReactomeiREACT_305967. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi20869650.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiSERPH_BOVIN
AccessioniPrimary (citable) accession number: Q2KJH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 7, 2006
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.