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Q2KJH6

- SERPH_BOVIN

UniProt

Q2KJH6 - SERPH_BOVIN

Protein

Serpin H1

Gene

SERPINH1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei377 – 3782Reactive bond homologBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. collagen biosynthetic process Source: Ensembl
    2. collagen fibril organization Source: Ensembl
    3. negative regulation of endopeptidase activity Source: RefGenome
    4. protein maturation Source: Ensembl
    5. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_215758. Collagen biosynthesis and modifying enzymes.

    Protein family/group databases

    MEROPSiI04.036.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin H1
    Alternative name(s):
    Collagen-binding protein
    Short name:
    Colligin
    Gene namesi
    Name:SERPINH1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 15

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
    3. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    4. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 418400Serpin H1PRO_0000253604Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941N6-succinyllysineBy similarity
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Modified residuei207 – 2071N6-acetyllysineBy similarity
    Modified residuei296 – 2961N6-succinyllysineBy similarity
    Modified residuei319 – 3191N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    PaxDbiQ2KJH6.
    PRIDEiQ2KJH6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000039506.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi415 – 4184Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 295Poly-Ala

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00750000117718.
    HOGENOMiHOG000238519.
    HOVERGENiHBG104930.
    InParanoidiQ2KJH6.
    KOiK09501.
    OMAiGVPMMHR.
    OrthoDBiEOG7GBFX4.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2KJH6-1 [UniParc]FASTAAdd to Basket

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    MRALLLISTI CLLARALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL    50
    AFSLYQAMAK DQAVENILLS PVVVASSLGL VSLGGKAATA SQAKAVLSAE 100
    QLRDDEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFAEDFVRSS 150
    KQHYNCEHSK INFRDKRSAL QSINEWAAQT TDGKLPEVTK DVERTDGALL 200
    VNAMFFKPHW DERFHHKMVD NRGFMVTRSY TVGVTMMHRT GLYNYYDDEK 250
    EKLQMVEMPL AHKLSSLIII MPHHVEPLER LEKLLTKEQL KVWMGKMQKK 300
    AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS 350
    VFHATAFEWD TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL 400
    LFIGRLVRPK GDKMRDEL 418
    Length:418
    Mass (Da):46,507
    Last modified:March 7, 2006 - v1
    Checksum:iDE81C53C711EF152
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105338 mRNA. Translation: AAI05339.1.
    RefSeqiNP_001039528.1. NM_001046063.1.
    XP_005216304.1. XM_005216247.1.
    XP_005216305.1. XM_005216248.1.
    UniGeneiBt.21385.

    Genome annotation databases

    EnsembliENSBTAT00000039717; ENSBTAP00000039506; ENSBTAG00000001027.
    GeneIDi510850.
    KEGGibta:510850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105338 mRNA. Translation: AAI05339.1 .
    RefSeqi NP_001039528.1. NM_001046063.1.
    XP_005216304.1. XM_005216247.1.
    XP_005216305.1. XM_005216248.1.
    UniGenei Bt.21385.

    3D structure databases

    ProteinModelPortali Q2KJH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000039506.

    Protein family/group databases

    MEROPSi I04.036.

    Proteomic databases

    PaxDbi Q2KJH6.
    PRIDEi Q2KJH6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000039717 ; ENSBTAP00000039506 ; ENSBTAG00000001027 .
    GeneIDi 510850.
    KEGGi bta:510850.

    Organism-specific databases

    CTDi 871.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00750000117718.
    HOGENOMi HOG000238519.
    HOVERGENi HBG104930.
    InParanoidi Q2KJH6.
    KOi K09501.
    OMAi GVPMMHR.
    OrthoDBi EOG7GBFX4.
    TreeFami TF343094.

    Enzyme and pathway databases

    Reactomei REACT_215758. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    NextBioi 20869650.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiSERPH_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3