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Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.By similarity

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Gene namesi
Name:WDR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 606605WD repeat-containing protein 1PRO_0000259955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei81 – 811N6-acetyllysineBy similarity
Modified residuei95 – 951N6-acetyllysineBy similarity
Modified residuei115 – 1151N6-acetyllysineBy similarity
Modified residuei238 – 2381PhosphotyrosineBy similarity
Modified residuei480 – 4801N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KJH4.
PRIDEiQ2KJH4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018092.

Structurei

3D structure databases

ProteinModelPortaliQ2KJH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati56 – 9540WD 1Add
BLAST
Repeati100 – 14344WD 2Add
BLAST
Repeati144 – 18441WD 3Add
BLAST
Repeati187 – 22640WD 4Add
BLAST
Repeati232 – 27140WD 5Add
BLAST
Repeati318 – 35942WD 6Add
BLAST
Repeati363 – 40139WD 7Add
BLAST
Repeati443 – 48240WD 8Add
BLAST
Repeati487 – 52640WD 9Add
BLAST
Repeati530 – 56940WD 10Add
BLAST
Repeati574 – 60532WD 11Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiQ2KJH4.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KIVGGDPKGN SFLYTNGKCV ILRNIDNPAI
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDSGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQSRPY RLVTGSDDNC AAFFEGPPFK FKFTISDHGR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIFIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVNVNSVVN TFTMGSNVLD QQLGCLWQKD HLLSISLSGY
310 320 330 340 350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFA GKGHTNQVSR MTVDEHGQLV SCSMDDTVRY TNLTLRDYSG
410 420 430 440 450
QGVVKLDVQP KCLAVGPGGY TVVVCIGQIV LLKDQRKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGETV AVGGADGNVR LYSILGTTLK DEGKLLEAKG PVTDLAFSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTIAY
Length:606
Mass (Da):66,258
Last modified:January 23, 2007 - v3
Checksum:i85B08DD828F2A439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105341 mRNA. Translation: AAI05342.1.
RefSeqiNP_001039811.1. NM_001046346.2.
UniGeneiBt.59546.

Genome annotation databases

GeneIDi533223.
KEGGibta:533223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105341 mRNA. Translation: AAI05342.1.
RefSeqiNP_001039811.1. NM_001046346.2.
UniGeneiBt.59546.

3D structure databases

ProteinModelPortaliQ2KJH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018092.

Proteomic databases

PaxDbiQ2KJH4.
PRIDEiQ2KJH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi533223.
KEGGibta:533223.

Organism-specific databases

CTDi9948.

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiQ2KJH4.

Miscellaneous databases

NextBioi20875962.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiWDR1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.