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Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Gene namesi
Name:WDR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projectionpodosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599551 – 606WD repeat-containing protein 1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei238PhosphotyrosineBy similarity1
Modified residuei480N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KJH4.
PeptideAtlasiQ2KJH4.
PRIDEiQ2KJH4.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018092.

Structurei

3D structure databases

ProteinModelPortaliQ2KJH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 95WD 1Add BLAST40
Repeati100 – 143WD 2Add BLAST44
Repeati144 – 184WD 3Add BLAST41
Repeati187 – 226WD 4Add BLAST40
Repeati232 – 271WD 5Add BLAST40
Repeati318 – 359WD 6Add BLAST42
Repeati363 – 401WD 7Add BLAST39
Repeati443 – 482WD 8Add BLAST40
Repeati487 – 526WD 9Add BLAST40
Repeati530 – 569WD 10Add BLAST40
Repeati574 – 605WD 11Add BLAST32

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiQ2KJH4.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KIVGGDPKGN SFLYTNGKCV ILRNIDNPAI
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDSGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQSRPY RLVTGSDDNC AAFFEGPPFK FKFTISDHGR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIFIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVNVNSVVN TFTMGSNVLD QQLGCLWQKD HLLSISLSGY
310 320 330 340 350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFA GKGHTNQVSR MTVDEHGQLV SCSMDDTVRY TNLTLRDYSG
410 420 430 440 450
QGVVKLDVQP KCLAVGPGGY TVVVCIGQIV LLKDQRKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGETV AVGGADGNVR LYSILGTTLK DEGKLLEAKG PVTDLAFSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTIAY
Length:606
Mass (Da):66,258
Last modified:January 23, 2007 - v3
Checksum:i85B08DD828F2A439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105341 mRNA. Translation: AAI05342.1.
RefSeqiNP_001039811.1. NM_001046346.2.
UniGeneiBt.59546.

Genome annotation databases

GeneIDi533223.
KEGGibta:533223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105341 mRNA. Translation: AAI05342.1.
RefSeqiNP_001039811.1. NM_001046346.2.
UniGeneiBt.59546.

3D structure databases

ProteinModelPortaliQ2KJH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018092.

Proteomic databases

PaxDbiQ2KJH4.
PeptideAtlasiQ2KJH4.
PRIDEiQ2KJH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi533223.
KEGGibta:533223.

Organism-specific databases

CTDi9948.

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiQ2KJH4.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.