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Q2KJG4

- MGST2_BOVIN

UniProt

Q2KJG4 - MGST2_BOVIN

Protein

Microsomal glutathione S-transferase 2

Gene

MGST2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione By similarity.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. enzyme activator activity Source: InterPro
    2. glutathione peroxidase activity Source: RefGenome
    3. glutathione transferase activity Source: RefGenome
    4. leukotriene-C4 synthase activity Source: RefGenome

    GO - Biological processi

    1. glutathione biosynthetic process Source: Ensembl
    2. leukotriene biosynthetic process Source: RefGenome
    3. oxidation-reduction process Source: GOC

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Leukotriene biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_223659. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microsomal glutathione S-transferase 2 (EC:2.5.1.18)
    Short name:
    Microsomal GST-2
    Gene namesi
    Name:MGST2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 17

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. nuclear envelope Source: RefGenome
    5. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 146146Microsomal glutathione S-transferase 2PRO_0000246087Add
    BLAST

    Proteomic databases

    PRIDEiQ2KJG4.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000029028.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MAPEG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77136.
    GeneTreeiENSGT00430000030964.
    HOGENOMiHOG000116372.
    HOVERGENiHBG105513.
    InParanoidiQ2KJG4.
    KOiK00799.
    OMAiTEWHSIT.
    OrthoDBiEOG7GXPD5.
    TreeFamiTF105328.

    Family and domain databases

    Gene3Di1.20.120.550. 1 hit.
    InterProiIPR001446. 5_LipOase_AP.
    IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view]
    PfamiPF01124. MAPEG. 1 hit.
    [Graphical view]
    PRINTSiPR00488. 5LPOXGNASEAP.

    Sequencei

    Sequence statusi: Complete.

    Q2KJG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF    50
    RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA 100
    AKKRVTGFRL SLGVLALLTV LGAVGILNSF LDEYLDIDIA KKLRHF 146
    Length:146
    Mass (Da):16,483
    Last modified:March 7, 2006 - v1
    Checksum:i24BCF4E5E9CE0393
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025439 mRNA. Translation: ABF57395.1.
    BC105356 mRNA. Translation: AAI05357.1.
    RefSeqiNP_001069850.1. NM_001076382.1.
    UniGeneiBt.21183.

    Genome annotation databases

    EnsembliENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
    GeneIDi615552.
    KEGGibta:615552.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025439 mRNA. Translation: ABF57395.1 .
    BC105356 mRNA. Translation: AAI05357.1 .
    RefSeqi NP_001069850.1. NM_001076382.1.
    UniGenei Bt.21183.

    3D structure databases

    ProteinModelPortali Q2KJG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000029028.

    Proteomic databases

    PRIDEi Q2KJG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000029028 ; ENSBTAP00000029028 ; ENSBTAG00000021779 .
    GeneIDi 615552.
    KEGGi bta:615552.

    Organism-specific databases

    CTDi 4258.

    Phylogenomic databases

    eggNOGi NOG77136.
    GeneTreei ENSGT00430000030964.
    HOGENOMi HOG000116372.
    HOVERGENi HBG105513.
    InParanoidi Q2KJG4.
    KOi K00799.
    OMAi TEWHSIT.
    OrthoDBi EOG7GXPD5.
    TreeFami TF105328.

    Enzyme and pathway databases

    Reactomei REACT_223659. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 20899667.

    Family and domain databases

    Gene3Di 1.20.120.550. 1 hit.
    InterProi IPR001446. 5_LipOase_AP.
    IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view ]
    Pfami PF01124. MAPEG. 1 hit.
    [Graphical view ]
    PRINTSi PR00488. 5LPOXGNASEAP.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiMGST2_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3