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Q2KJG4 (MGST2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microsomal glutathione S-transferase 2

Short name=Microsomal GST-2
EC=2.5.1.18
Gene names
Name:MGST2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homotrimer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. Microsome membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the MAPEG family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 146146Microsomal glutathione S-transferase 2
PRO_0000246087

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane111 – 13121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2KJG4 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 24BCF4E5E9CE0393

FASTA14616,483
        10         20         30         40         50         60 
MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF RAQQNCVEFY 

        70         80         90        100        110        120 
PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA AKKRVTGFRL SLGVLALLTV 

       130        140 
LGAVGILNSF LDEYLDIDIA KKLRHF 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT025439 mRNA. Translation: ABF57395.1.
BC105356 mRNA. Translation: AAI05357.1.
RefSeqNP_001069850.1. NM_001076382.1.
UniGeneBt.21183.

3D structure databases

ProteinModelPortalQ2KJG4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000029028.

Proteomic databases

PRIDEQ2KJG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
GeneID615552.
KEGGbta:615552.

Organism-specific databases

CTD4258.

Phylogenomic databases

eggNOGNOG77136.
GeneTreeENSGT00430000030964.
HOGENOMHOG000116372.
HOVERGENHBG105513.
InParanoidQ2KJG4.
KOK00799.
OMAIFRAQQN.
OrthoDBEOG7GXPD5.
TreeFamTF105328.

Family and domain databases

Gene3D1.20.120.550. 1 hit.
InterProIPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSPR00488. 5LPOXGNASEAP.
ProtoNetSearch...

Other

NextBio20899667.

Entry information

Entry nameMGST2_BOVIN
AccessionPrimary (citable) accession number: Q2KJG4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families