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Protein

Microsomal glutathione S-transferase 2

Gene

MGST2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro
  2. glutathione peroxidase activity Source: GO_Central
  3. glutathione transferase activity Source: GO_Central
  4. leukotriene-C4 synthase activity Source: GO_Central

GO - Biological processi

  1. glutathione biosynthetic process Source: Ensembl
  2. leukotriene biosynthetic process Source: GO_Central
  3. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Leukotriene biosynthesis

Enzyme and pathway databases

ReactomeiREACT_223659. Glutathione conjugation.
REACT_236796. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 2 (EC:2.5.1.18)
Short name:
Microsomal GST-2
Gene namesi
Name:MGST2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear envelope Source: GO_Central
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Microsomal glutathione S-transferase 2PRO_0000246087Add
BLAST

Proteomic databases

PRIDEiQ2KJG4.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029028.

Structurei

3D structure databases

ProteinModelPortaliQ2KJG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77136.
GeneTreeiENSGT00430000030964.
HOGENOMiHOG000116372.
HOVERGENiHBG105513.
InParanoidiQ2KJG4.
KOiK00799.
OMAiIFRAQQN.
OrthoDBiEOG7GXPD5.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.

Sequencei

Sequence statusi: Complete.

Q2KJG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF
60 70 80 90 100
RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA
110 120 130 140
AKKRVTGFRL SLGVLALLTV LGAVGILNSF LDEYLDIDIA KKLRHF
Length:146
Mass (Da):16,483
Last modified:March 7, 2006 - v1
Checksum:i24BCF4E5E9CE0393
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025439 mRNA. Translation: ABF57395.1.
BC105356 mRNA. Translation: AAI05357.1.
RefSeqiNP_001069850.1. NM_001076382.1.
UniGeneiBt.21183.

Genome annotation databases

EnsembliENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
GeneIDi615552.
KEGGibta:615552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025439 mRNA. Translation: ABF57395.1.
BC105356 mRNA. Translation: AAI05357.1.
RefSeqiNP_001069850.1. NM_001076382.1.
UniGeneiBt.21183.

3D structure databases

ProteinModelPortaliQ2KJG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029028.

Proteomic databases

PRIDEiQ2KJG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
GeneIDi615552.
KEGGibta:615552.

Organism-specific databases

CTDi4258.

Phylogenomic databases

eggNOGiNOG77136.
GeneTreeiENSGT00430000030964.
HOGENOMiHOG000116372.
HOVERGENiHBG105513.
InParanoidiQ2KJG4.
KOiK00799.
OMAiIFRAQQN.
OrthoDBiEOG7GXPD5.
TreeFamiTF105328.

Enzyme and pathway databases

ReactomeiREACT_223659. Glutathione conjugation.
REACT_236796. Aflatoxin activation and detoxification.

Miscellaneous databases

NextBioi20899667.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiMGST2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: February 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.