Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microsomal glutathione S-transferase 2

Gene

MGST2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLeukotriene biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-156590 Glutathione conjugation
R-BTA-5423646 Aflatoxin activation and detoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 2 (EC:2.5.1.18)
Short name:
Microsomal GST-2
Gene namesi
Name:MGST2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:31452 MGST2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002460871 – 146Microsomal glutathione S-transferase 2Add BLAST146

Proteomic databases

PaxDbiQ2KJG4
PRIDEiQ2KJG4

Expressioni

Gene expression databases

BgeeiENSBTAG00000021779

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029028

Structurei

3D structure databases

ProteinModelPortaliQ2KJG4
SMRiQ2KJG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX5K Eukaryota
ENOG41121Z4 LUCA
GeneTreeiENSGT00430000030964
HOGENOMiHOG000116372
HOVERGENiHBG105513
InParanoidiQ2KJG4
KOiK00799
OMAiIFRAQQN
OrthoDBiEOG091G12NW
TreeFamiTF105328

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR001446 5_LipOase_AP
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
PRINTSiPR00488 5LPOXGNASEAP
SUPFAMiSSF161084 SSF161084, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KJG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF
60 70 80 90 100
RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA
110 120 130 140
AKKRVTGFRL SLGVLALLTV LGAVGILNSF LDEYLDIDIA KKLRHF
Length:146
Mass (Da):16,483
Last modified:March 7, 2006 - v1
Checksum:i24BCF4E5E9CE0393
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025439 mRNA Translation: ABF57395.1
BC105356 mRNA Translation: AAI05357.1
RefSeqiNP_001069850.1, NM_001076382.1
UniGeneiBt.21183

Genome annotation databases

EnsembliENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779
GeneIDi615552
KEGGibta:615552

Similar proteinsi

Entry informationi

Entry nameiMGST2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health