Q2KJG4 (MGST2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microsomal glutathione S-transferase 2
Short name=Microsomal GST-2
EC=2.5.1.18

Gene names

Name:

MGST2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homotrimer By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. Microsome membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the MAPEG family.

Ontologies

Keywords
Biological process	Leukotriene biosynthesis
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione biosynthetic process Inferred from Biological aspect of Ancestor. Source: RefGenome leukotriene biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW leukotriene metabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of catalytic activity Inferred from electronic annotation. Source: GOC
Cellular_component	endoplasmic reticulum Inferred from Biological aspect of Ancestor. Source: RefGenome endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	enzyme activator activity Inferred from electronic annotation. Source: InterPro glutathione peroxidase activity Inferred from Biological aspect of Ancestor. Source: RefGenome glutathione transferase activity Inferred from Biological aspect of Ancestor. Source: RefGenome leukotriene-C4 synthase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Microsomal glutathione S-transferase 2		PRO_0000246087
Regions
	Transmembrane	6 – 26	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2KJG4 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 24BCF4E5E9CE0393	FASTA	146	16,483
	10 20 30 40 50 60 MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF RAQQNCVEFY 70 80 90 100 110 120 PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA AKKRVTGFRL SLGVLALLTV 130 140 LGAVGILNSF LDEYLDIDIA KKLRHF

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT025439 mRNA. Translation: ABF57395.1. BC105356 mRNA. Translation: AAI05357.1.
IPI	IPI00716443.
RefSeq	NP_001069850.1. NM_001076382.1.
UniGene	Bt.21183.
3D structure databases
ProteinModelPortal	Q2KJG4.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000029028.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
GeneID	615552.
KEGG	bta:615552.
Organism-specific databases
CTD	4258.
Phylogenomic databases
eggNOG	NOG77136.
GeneTree	ENSGT00430000030964.
HOGENOM	HOG000116372.
HOVERGEN	HBG105513.
InParanoid	Q2KJG4.
KO	K00799.
OMA	LYIYARH.
OrthoDB	EOG4V1729.
Family and domain databases
Gene3D	1.20.120.550. 1 hit.
InterPro	IPR001446. 5_LipOase_AP. IPR023352. MAPEG-like_dom. IPR001129. Membr-assoc_MAPEG. [Graphical view]
Pfam	PF01124. MAPEG. 1 hit. [Graphical view]
PRINTS	PR00488. 5LPOXGNASEAP.
ProtoNet	Search...
Other
NextBio	20899667.

Entry information

Entry name

MGST2_BOVIN

Accession

Primary (citable) accession number: Q2KJG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 7, 2006
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program