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Q2KJG4

- MGST2_BOVIN

UniProt

Q2KJG4 - MGST2_BOVIN

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Protein

Microsomal glutathione S-transferase 2

Gene

MGST2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro
  2. glutathione peroxidase activity Source: RefGenome
  3. glutathione transferase activity Source: RefGenome
  4. leukotriene-C4 synthase activity Source: RefGenome

GO - Biological processi

  1. glutathione biosynthetic process Source: Ensembl
  2. leukotriene biosynthetic process Source: RefGenome
  3. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Leukotriene biosynthesis

Enzyme and pathway databases

ReactomeiREACT_223659. Glutathione conjugation.
REACT_236796. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 2 (EC:2.5.1.18)
Short name:
Microsomal GST-2
Gene namesi
Name:MGST2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear envelope Source: RefGenome
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Microsomal glutathione S-transferase 2PRO_0000246087Add
BLAST

Proteomic databases

PRIDEiQ2KJG4.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029028.

Structurei

3D structure databases

ProteinModelPortaliQ2KJG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77136.
GeneTreeiENSGT00430000030964.
HOGENOMiHOG000116372.
HOVERGENiHBG105513.
InParanoidiQ2KJG4.
KOiK00799.
OMAiTEWHSIT.
OrthoDBiEOG7GXPD5.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.

Sequencei

Sequence statusi: Complete.

Q2KJG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF
60 70 80 90 100
RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA
110 120 130 140
AKKRVTGFRL SLGVLALLTV LGAVGILNSF LDEYLDIDIA KKLRHF
Length:146
Mass (Da):16,483
Last modified:March 7, 2006 - v1
Checksum:i24BCF4E5E9CE0393
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025439 mRNA. Translation: ABF57395.1.
BC105356 mRNA. Translation: AAI05357.1.
RefSeqiNP_001069850.1. NM_001076382.1.
UniGeneiBt.21183.

Genome annotation databases

EnsembliENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
GeneIDi615552.
KEGGibta:615552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025439 mRNA. Translation: ABF57395.1 .
BC105356 mRNA. Translation: AAI05357.1 .
RefSeqi NP_001069850.1. NM_001076382.1.
UniGenei Bt.21183.

3D structure databases

ProteinModelPortali Q2KJG4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000029028.

Proteomic databases

PRIDEi Q2KJG4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000029028 ; ENSBTAP00000029028 ; ENSBTAG00000021779 .
GeneIDi 615552.
KEGGi bta:615552.

Organism-specific databases

CTDi 4258.

Phylogenomic databases

eggNOGi NOG77136.
GeneTreei ENSGT00430000030964.
HOGENOMi HOG000116372.
HOVERGENi HBG105513.
InParanoidi Q2KJG4.
KOi K00799.
OMAi TEWHSIT.
OrthoDBi EOG7GXPD5.
TreeFami TF105328.

Enzyme and pathway databases

Reactomei REACT_223659. Glutathione conjugation.
REACT_236796. Aflatoxin activation and detoxification.

Miscellaneous databases

NextBioi 20899667.

Family and domain databases

Gene3Di 1.20.120.550. 1 hit.
InterProi IPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view ]
Pfami PF01124. MAPEG. 1 hit.
[Graphical view ]
PRINTSi PR00488. 5LPOXGNASEAP.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiMGST2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3