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Q2KJG4

- MGST2_BOVIN

UniProt

Q2KJG4 - MGST2_BOVIN

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Protein
Microsomal glutathione S-transferase 2
Gene
MGST2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro
  2. glutathione peroxidase activity Source: RefGenome
  3. glutathione transferase activity Source: RefGenome
  4. leukotriene-C4 synthase activity Source: RefGenome

GO - Biological processi

  1. glutathione biosynthetic process Source: Ensembl
  2. leukotriene biosynthetic process Source: RefGenome
  3. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Leukotriene biosynthesis

Enzyme and pathway databases

ReactomeiREACT_223659. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 2 (EC:2.5.1.18)
Short name:
Microsomal GST-2
Gene namesi
Name:MGST2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Transmembranei111 – 13121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear envelope Source: RefGenome
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Microsomal glutathione S-transferase 2
PRO_0000246087Add
BLAST

Proteomic databases

PRIDEiQ2KJG4.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029028.

Structurei

3D structure databases

ProteinModelPortaliQ2KJG4.

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77136.
GeneTreeiENSGT00430000030964.
HOGENOMiHOG000116372.
HOVERGENiHBG105513.
InParanoidiQ2KJG4.
KOiK00799.
OMAiTEWHSIT.
OrthoDBiEOG7GXPD5.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.

Sequencei

Sequence statusi: Complete.

Q2KJG4-1 [UniParc]FASTAAdd to Basket

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MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF    50
RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA 100
AKKRVTGFRL SLGVLALLTV LGAVGILNSF LDEYLDIDIA KKLRHF 146
Length:146
Mass (Da):16,483
Last modified:March 7, 2006 - v1
Checksum:i24BCF4E5E9CE0393
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT025439 mRNA. Translation: ABF57395.1.
BC105356 mRNA. Translation: AAI05357.1.
RefSeqiNP_001069850.1. NM_001076382.1.
UniGeneiBt.21183.

Genome annotation databases

EnsembliENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
GeneIDi615552.
KEGGibta:615552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT025439 mRNA. Translation: ABF57395.1 .
BC105356 mRNA. Translation: AAI05357.1 .
RefSeqi NP_001069850.1. NM_001076382.1.
UniGenei Bt.21183.

3D structure databases

ProteinModelPortali Q2KJG4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000029028.

Proteomic databases

PRIDEi Q2KJG4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000029028 ; ENSBTAP00000029028 ; ENSBTAG00000021779 .
GeneIDi 615552.
KEGGi bta:615552.

Organism-specific databases

CTDi 4258.

Phylogenomic databases

eggNOGi NOG77136.
GeneTreei ENSGT00430000030964.
HOGENOMi HOG000116372.
HOVERGENi HBG105513.
InParanoidi Q2KJG4.
KOi K00799.
OMAi TEWHSIT.
OrthoDBi EOG7GXPD5.
TreeFami TF105328.

Enzyme and pathway databases

Reactomei REACT_223659. Glutathione conjugation.

Miscellaneous databases

NextBioi 20899667.

Family and domain databases

Gene3Di 1.20.120.550. 1 hit.
InterProi IPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view ]
Pfami PF01124. MAPEG. 1 hit.
[Graphical view ]
PRINTSi PR00488. 5LPOXGNASEAP.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiMGST2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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