ID   SYNC_BOVIN              Reviewed;         559 AA.
AC   Q2KJG3;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 3.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Asparaginyl-tRNA synthetase, cytoplasmic;
DE            EC=6.1.1.22;
DE   AltName: Full=Asparagine--tRNA ligase;
DE            Short=AsnRS;
GN   Name=NARS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-asparagine + tRNA(Asn) = AMP +
CC       diphosphate + L-asparaginyl-tRNA(Asn).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family.
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DR   EMBL; BC105358; AAI05359.1; -; mRNA.
DR   IPI; IPI00707250; -.
DR   RefSeq; NP_001040037.1; -.
DR   UniGene; Bt.51668; -.
DR   Ensembl; ENSBTAG00000019271; Bos taurus.
DR   GeneID; 616033; -.
DR   KEGG; bta:616033; -.
DR   HOVERGEN; Q2KJG3; -.
DR   BRENDA; 6.1.1.22; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004816; F:asparagine-tRNA ligase activity; IEA:EC.
DR   GO; GO:0004815; F:aspartate-tRNA ligase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006421; P:asparaginyl-tRNA aminoacylation; IEA:InterPro.
DR   GO; GO:0006422; P:aspartyl-tRNA aminoacylation; IEA:InterPro.
DR   InterPro; IPR004364; aa-tRNA-synt_II.
DR   InterPro; IPR018150; aa-tRNA-synt_II-like.
DR   InterPro; IPR006195; aa-tRNA-synth_II_cons-reg.
DR   InterPro; IPR004522; Asn-tRNA-synth_IIb.
DR   InterPro; IPR002312; Asp-tRNA-synth_IIb.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA_bd_OB_tRNA-helicase.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   PANTHER; PTHR22594; aa-tRNA-synt_II; 1.
DR   Pfam; PF00152; tRNA-synt_2; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   PRINTS; PR01042; TRNASYNTHASP.
DR   TIGRFAMs; TIGR00457; asnS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   2: Evidence at transcript level;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Phosphoprotein; Protein biosynthesis.
FT   CHAIN         1    559       Asparaginyl-tRNA synthetase, cytoplasmic.
FT                                /FTId=PRO_0000284071.
FT   MOD_RES      72     72       Phosphoserine (By similarity).
SQ   SEQUENCE   559 AA;  64399 MW;  95E21B2DCF629C31 CRC64;
     MSLEVVRAAA GMVLAELYVS DREGNDVTGD GTKEKPFKTG LKALMTVGKE PFPTIYVDSQ
     KENERWDVIS KSQMKNIRKL WHREQMKSES REKKEAEDNL RREKNLEEAK KITIKNDPSL
     PEPKCVKIRE LKGYRGQRIK VFGWVHRLRR QGKNLMFLVL RDGTGFLQCV LSDDLCQCYN
     GVVLSTESSV AVYGVLNLTP KGKQAPGGHE LSCDFWELIG LAPAGGADNL INEESDVDVQ
     LNNRHMMIRG ENMSKILKAR SVITRCFRDH FFDRGYHEIT PPTLVQTQVE GGATLFKLDY
     FGEEAYLTQS SQLYLETCIP ALGDVFCIAQ SYRAEQSRTR RHLAEYTHVE AECPFLTFEE
     LLNRLEDLVC DVVDRVLKSP AGNIVRDLNP NFKPPKRPFK RMNYSDAIVW LKEHNIKKED
     GTFYEFGEDI PEAPERLMTD TINEPILLCR FPVEIKSFYM QRCPEDPRLT ESVDVLMPNV
     GEIVGGSMRI WDNEEILAGY KREGIDPTPY YWYTDQRKYG TCPHGGYGLG LERFLTWILD
     RYHIRDVCLY PRFVQRCKP
//