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Protein

Asparagine--tRNA ligase, cytoplasmic

Gene

NARS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine--tRNA ligase, cytoplasmic (EC:6.1.1.22)
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name:
AsnRS
Gene namesi
Name:NARS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Asparagine--tRNA ligase, cytoplasmicPRO_0000284071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei255 – 2551N6-acetyllysineBy similarity
Modified residuei501 – 5011N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KJG3.
PRIDEiQ2KJG3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025659.

Structurei

3D structure databases

ProteinModelPortaliQ2KJG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0555. Eukaryota.
COG0017. LUCA.
HOGENOMiHOG000226035.
HOVERGENiHBG059844.
InParanoidiQ2KJG3.
KOiK01893.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF16. PTHR22594:SF16. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEVVRAAA GMVLAELYVS DREGNDVTGD GTKEKPFKTG LKALMTVGKE
60 70 80 90 100
PFPTIYVDSQ KENERWDVIS KSQMKNIRKL WHREQMKSES REKKEAEDNL
110 120 130 140 150
RREKNLEEAK KITIKNDPSL PEPKCVKIRE LKGYRGQRIK VFGWVHRLRR
160 170 180 190 200
QGKNLMFLVL RDGTGFLQCV LSDDLCQCYN GVVLSTESSV AVYGVLNLTP
210 220 230 240 250
KGKQAPGGHE LSCDFWELIG LAPAGGADNL INEESDVDVQ LNNRHMMIRG
260 270 280 290 300
ENMSKILKAR SVITRCFRDH FFDRGYHEIT PPTLVQTQVE GGATLFKLDY
310 320 330 340 350
FGEEAYLTQS SQLYLETCIP ALGDVFCIAQ SYRAEQSRTR RHLAEYTHVE
360 370 380 390 400
AECPFLTFEE LLNRLEDLVC DVVDRVLKSP AGNIVRDLNP NFKPPKRPFK
410 420 430 440 450
RMNYSDAIVW LKEHNIKKED GTFYEFGEDI PEAPERLMTD TINEPILLCR
460 470 480 490 500
FPVEIKSFYM QRCPEDPRLT ESVDVLMPNV GEIVGGSMRI WDNEEILAGY
510 520 530 540 550
KREGIDPTPY YWYTDQRKYG TCPHGGYGLG LERFLTWILD RYHIRDVCLY

PRFVQRCKP
Length:559
Mass (Da):64,399
Last modified:July 1, 2008 - v3
Checksum:i95E21B2DCF629C31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105358 mRNA. Translation: AAI05359.1.
RefSeqiNP_001040037.1. NM_001046572.2.
UniGeneiBt.51668.

Genome annotation databases

GeneIDi616033.
KEGGibta:616033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105358 mRNA. Translation: AAI05359.1.
RefSeqiNP_001040037.1. NM_001046572.2.
UniGeneiBt.51668.

3D structure databases

ProteinModelPortaliQ2KJG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025659.

Proteomic databases

PaxDbiQ2KJG3.
PRIDEiQ2KJG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi616033.
KEGGibta:616033.

Organism-specific databases

CTDi4677.

Phylogenomic databases

eggNOGiKOG0555. Eukaryota.
COG0017. LUCA.
HOGENOMiHOG000226035.
HOVERGENiHBG059844.
InParanoidiQ2KJG3.
KOiK01893.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF16. PTHR22594:SF16. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiSYNC_BOVIN
AccessioniPrimary (citable) accession number: Q2KJG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.