Reviewed, UniProtKB/Swiss-Prot Q2KJG3 (SYNC_BOVIN)

Names and origin

Protein names

Recommended name:
    Asparaginyl-tRNA synthetase, cytoplasmic
    EC=6.1.1.22
Alternative name(s):
    Asparagine--tRNA ligase
      Short name=AsnRS

Gene names

Name:

NARS

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activity Inferred from electronic annotation. Source: EC aspartate-tRNA ligase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Asparaginyl-tRNA synthetase, cytoplasmic		PRO_0000284071
Amino acid modifications
	Modified residue	72	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KJG3-1 [UniParc]. Last modified July 1, 2008. Version 3. Checksum: 95E21B2DCF629C31	FASTA	559	64,399
	10 20 30 40 50 60 MSLEVVRAAA GMVLAELYVS DREGNDVTGD GTKEKPFKTG LKALMTVGKE PFPTIYVDSQ 70 80 90 100 110 120 KENERWDVIS KSQMKNIRKL WHREQMKSES REKKEAEDNL RREKNLEEAK KITIKNDPSL 130 140 150 160 170 180 PEPKCVKIRE LKGYRGQRIK VFGWVHRLRR QGKNLMFLVL RDGTGFLQCV LSDDLCQCYN 190 200 210 220 230 240 GVVLSTESSV AVYGVLNLTP KGKQAPGGHE LSCDFWELIG LAPAGGADNL INEESDVDVQ 250 260 270 280 290 300 LNNRHMMIRG ENMSKILKAR SVITRCFRDH FFDRGYHEIT PPTLVQTQVE GGATLFKLDY 310 320 330 340 350 360 FGEEAYLTQS SQLYLETCIP ALGDVFCIAQ SYRAEQSRTR RHLAEYTHVE AECPFLTFEE 370 380 390 400 410 420 LLNRLEDLVC DVVDRVLKSP AGNIVRDLNP NFKPPKRPFK RMNYSDAIVW LKEHNIKKED 430 440 450 460 470 480 GTFYEFGEDI PEAPERLMTD TINEPILLCR FPVEIKSFYM QRCPEDPRLT ESVDVLMPNV 490 500 510 520 530 540 GEIVGGSMRI WDNEEILAGY KREGIDPTPY YWYTDQRKYG TCPHGGYGLG LERFLTWILD 550 RYHIRDVCLY PRFVQRCKP

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC105358 mRNA. Translation: AAI05359.1.
IPI	IPI00707250.
RefSeq	NP_001040037.1.
UniGene	Bt.51668
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000019271. Bos taurus. [Contig view]
GeneID	616033.
KEGG	bta:616033.
Phylogenomic databases
HOVERGEN	Q2KJG3.
Enzyme and pathway databases
BRENDA	6.1.1.22. 251.
Family and domain databases
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00457. asnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYNC_BOVIN

Accession

Primary (citable) accession number: Q2KJG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	July 1, 2008
Last modified:	June 16, 2009
This is version 31 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)