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Protein

Electron transfer flavoprotein subunit alpha, mitochondrial

Gene

ETFA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).By similarity

Cofactori

FADBy similarityNote: Binds 1 FAD per dimer.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi274 – 302FADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein subunit alpha, mitochondrial
Short name:
Alpha-ETF
Gene namesi
Name:ETFA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000024719420 – 333Electron transfer flavoprotein subunit alpha, mitochondrialAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59N6-acetyllysine; alternateBy similarity1
Modified residuei59N6-succinyllysine; alternateBy similarity1
Modified residuei62N6-acetyllysineBy similarity1
Modified residuei69N6-acetyllysine; alternateBy similarity1
Modified residuei69N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei85N6-acetyllysine; alternateBy similarity1
Modified residuei85N6-succinyllysine; alternateBy similarity1
Modified residuei93PhosphothreonineBy similarity1
Modified residuei101N6-acetyllysineBy similarity1
Modified residuei139N6-acetyllysineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei158N6-acetyllysine; alternateBy similarity1
Modified residuei158N6-succinyllysine; alternateBy similarity1
Modified residuei164N6-acetyllysineBy similarity1
Modified residuei187N6-succinyllysineBy similarity1
Modified residuei203N6-acetyllysine; alternateBy similarity1
Modified residuei203N6-succinyllysine; alternateBy similarity1
Modified residuei216N6-succinyllysineBy similarity1
Modified residuei226N6-acetyllysine; alternateBy similarity1
Modified residuei226N6-succinyllysine; alternateBy similarity1
Modified residuei232N6-acetyllysine; alternateBy similarity1
Modified residuei232N6-succinyllysine; alternateBy similarity1
Modified residuei301N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KJE4.
PeptideAtlasiQ2KJE4.
PRIDEiQ2KJE4.

Interactioni

Subunit structurei

Electron transfer flavoprotein is a heterodimer composed of ETFA and ETFB. Interacts with ETFRF1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016570.

Structurei

3D structure databases

ProteinModelPortaliQ2KJE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 204Domain IBy similarityAdd BLAST185
Regioni205 – 333Domain IIBy similarityAdd BLAST129

Domaini

Domain I shares an identical polypeptide fold with the beta subunit ETFB though there is no sequence similarity.By similarity

Sequence similaritiesi

Belongs to the ETF alpha-subunit/FixB family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3954. Eukaryota.
COG2025. LUCA.
HOGENOMiHOG000247865.
HOVERGENiHBG002317.
InParanoidiQ2KJE4.
KOiK03522.

Family and domain databases

CDDicd01715. ETF_alpha. 1 hit.
Gene3Di3.40.50.1220. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR014730. ETF_a/b_N.
IPR001308. ETF_a/FixB.
IPR033947. ETF_alpha_N.
IPR014731. ETF_asu_C.
IPR018206. ETF_asu_C_CS.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01012. ETF. 1 hit.
PF00766. ETF_alpha. 1 hit.
[Graphical view]
PIRSFiPIRSF000089. Electra_flavoP_a. 1 hit.
SMARTiSM00893. ETF. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS00696. ETF_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRAAAPGQL RRATSLLRFQ STLVIAEHAN DTLAPITLNT ITAAKHLGGE
60 70 80 90 100
VSCLVAGTKC DKVAQDLCKV AGVAKVLVAQ HDAYKGLLPE ELTPLILATQ
110 120 130 140 150
KQFNHTHICA GASAFGKNLL PRIAAKLDVA PISDIIAIKS PDTFVRTIYA
160 170 180 190 200
GNAICTVKCD EKVKVFSVRG TSFEAAAASG GSASSEKASS TSPVGISEWL
210 220 230 240 250
DQKLTKSDRP ELTGAKVVVS GGRGLKSGEN FKLLYDLADQ LHAAVGASRA
260 270 280 290 300
AVDAGFVTND LQVGQTGKIV APELYIAVGI SGAIQHLAGM KDSKTIVAIN
310 320 330
KDPEAPIFQV ADYGIVADLF KVVPEMTELL KKK
Length:333
Mass (Da):34,961
Last modified:March 7, 2006 - v1
Checksum:i8E05E2B71A822510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105382 mRNA. Translation: AAI05383.1.
RefSeqiNP_001069290.1. NM_001075822.1.
UniGeneiBt.5350.

Genome annotation databases

GeneIDi521892.
KEGGibta:521892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105382 mRNA. Translation: AAI05383.1.
RefSeqiNP_001069290.1. NM_001075822.1.
UniGeneiBt.5350.

3D structure databases

ProteinModelPortaliQ2KJE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016570.

Proteomic databases

PaxDbiQ2KJE4.
PeptideAtlasiQ2KJE4.
PRIDEiQ2KJE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi521892.
KEGGibta:521892.

Organism-specific databases

CTDi2108.

Phylogenomic databases

eggNOGiKOG3954. Eukaryota.
COG2025. LUCA.
HOGENOMiHOG000247865.
HOVERGENiHBG002317.
InParanoidiQ2KJE4.
KOiK03522.

Family and domain databases

CDDicd01715. ETF_alpha. 1 hit.
Gene3Di3.40.50.1220. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR014730. ETF_a/b_N.
IPR001308. ETF_a/FixB.
IPR033947. ETF_alpha_N.
IPR014731. ETF_asu_C.
IPR018206. ETF_asu_C_CS.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01012. ETF. 1 hit.
PF00766. ETF_alpha. 1 hit.
[Graphical view]
PIRSFiPIRSF000089. Electra_flavoP_a. 1 hit.
SMARTiSM00893. ETF. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS00696. ETF_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETFA_BOVIN
AccessioniPrimary (citable) accession number: Q2KJE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.