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Protein

Tax1-binding protein 1 homolog

Gene

TAX1BP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri753 – 78230UBZ-type 1Add
BLAST
Zinc fingeri783 – 81735UBZ-type 2Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-5357905. Regulation of TNFR1 signaling.
R-BTA-936440. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 1 homolog
Gene namesi
Name:TAX1BP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Tax1-binding protein 1 homologPRO_0000234553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241PhosphoserineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity
Modified residuei617 – 6171Phosphoserine; by IKKABy similarity
Modified residuei633 – 6331PhosphoserineBy similarity
Modified residuei694 – 6941Phosphoserine; by IKKABy similarity

Post-translational modificationi

Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KJE0.
PRIDEiQ2KJE0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019020.

Interactioni

Subunit structurei

Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033573.

Structurei

3D structure databases

ProteinModelPortaliQ2KJE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni320 – 420101OligomerizationBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 628485Sequence analysisAdd
BLAST

Domaini

The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri753 – 78230UBZ-type 1Add
BLAST
Zinc fingeri783 – 81735UBZ-type 2Add
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGMS. Eukaryota.
ENOG410XQDF. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000252947.
HOVERGENiHBG053034.
InParanoidiQ2KJE0.
OMAiRKMEGQN.
OrthoDBiEOG091G01W2.
TreeFamiTF329501.

Family and domain databases

InterProiIPR012852. CALCOCO1-like.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV
60 70 80 90 100
GIFKVGWSTA RDYYTFLWSP MPEHYVEGSA VNCELAFQGY YLPNDDGEFY
110 120 130 140 150
QFCYVTHKGE IRGASTPFQF RAASPVEELL TMEDEGNSDM LVVTTKAGLL
160 170 180 190 200
ELKIEKTMKE KEELLKLIAV LEKETTQLRE QVGRMERELN HEKERGDQLQ
210 220 230 240 250
AEQKALTKVS QSLKMENEEF KKRYNDVTSK ALQLEEDIVS VTHKAIEKET
260 270 280 290 300
ELDSLKDKLK KAQCEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLVSE
310 320 330 340 350
VQTLKNLDGN KENMITHFKE EISRLQFSLA EKENLQRTFL LTTSSKEDTF
360 370 380 390 400
ILKEQLRKAE EQIQATRQEA VFLAKELSDA VNVRDKTMAD LHTAHLENEK
410 420 430 440 450
VKKQLTDALA ELKLSAVNKD QEKTDTLEHE LRREVEDLKL RLQMAADHYK
460 470 480 490 500
EKFKECQRLQ KQINKLSDQS ANSNSVFTKK IGSQQKVNDA SINTDPAATA
510 520 530 540 550
STVDVKPLPS TAETDFDNLT KGQVSEMTKE IADKTEKYNK CKQLLQDEKT
560 570 580 590 600
KCNKYADELA KMELKWKEQV KIAENIKLEL AEVVDNYKLQ LAEKEKEISG
610 620 630 640 650
LTSYWENLSR EKEHKRSVEN QAERKLEGQN SQSPHQISQC LKTSSEKSGH
660 670 680 690 700
VPAVSNTQPV LQYGNPYATP ETRDGADGAF YPDEIQRPPV RVPSWGLEDN
710 720 730 740 750
VVCSQPARNL SRPDGLEDPE DSKEDEKVPT APDPPSQHLR GHGTGFCFDP
760 770 780 790 800
SFDVQKKCPL CELMFPPNYD QSKFEEHVES HWKVCPMCSE QFPPDYDQQV
810
FERHVQTHFD QNVLNFD
Length:817
Mass (Da):94,059
Last modified:March 7, 2006 - v1
Checksum:i5293ED0CB703F092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105389 mRNA. Translation: AAI05390.1.
RefSeqiNP_001039874.1. NM_001046409.2.
XP_005205596.1. XM_005205539.3.
UniGeneiBt.17392.

Genome annotation databases

EnsembliENSBTAT00000033663; ENSBTAP00000033573; ENSBTAG00000019020.
GeneIDi535589.
KEGGibta:535589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105389 mRNA. Translation: AAI05390.1.
RefSeqiNP_001039874.1. NM_001046409.2.
XP_005205596.1. XM_005205539.3.
UniGeneiBt.17392.

3D structure databases

ProteinModelPortaliQ2KJE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033573.

Proteomic databases

PaxDbiQ2KJE0.
PRIDEiQ2KJE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000033663; ENSBTAP00000033573; ENSBTAG00000019020.
GeneIDi535589.
KEGGibta:535589.

Organism-specific databases

CTDi8887.

Phylogenomic databases

eggNOGiENOG410IGMS. Eukaryota.
ENOG410XQDF. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000252947.
HOVERGENiHBG053034.
InParanoidiQ2KJE0.
OMAiRKMEGQN.
OrthoDBiEOG091G01W2.
TreeFamiTF329501.

Enzyme and pathway databases

ReactomeiR-BTA-5357905. Regulation of TNFR1 signaling.
R-BTA-936440. Negative regulators of RIG-I/MDA5 signaling.

Gene expression databases

BgeeiENSBTAG00000019020.

Family and domain databases

InterProiIPR012852. CALCOCO1-like.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAXB1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.