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Protein

Cyclin-dependent kinase 4 inhibitor B

Gene

CDKN2B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
Gene namesi
Name:CDKN2B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108561 – 131Cyclin-dependent kinase 4 inhibitor BAdd BLAST131

Proteomic databases

PaxDbiQ2KJD8
PRIDEiQ2KJD8

Interactioni

Subunit structurei

Heterodimer of CDKN2B with CDK4 or CDK6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002652

Structurei

3D structure databases

ProteinModelPortaliQ2KJD8
SMRiQ2KJD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 35ANK 1Add BLAST30
Repeati39 – 67ANK 2Add BLAST29
Repeati72 – 101ANK 3Add BLAST30
Repeati105 – 131ANK 4Add BLAST27

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiQ2KJD8
KOiK04685

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KJD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGGGGDAD LANAAARGQV EAVRQLLEAG VDPNRLNRFG RRPIQVMMMG
60 70 80 90 100
SARVAELLLL HGADPNCADP ATLTRPVHDA AREGFLDTLV ALHRAGGRLD
110 120 130
VRDAWGRLPV DLAEERGHRD VARYLRATAG D
Length:131
Mass (Da):14,028
Last modified:March 7, 2006 - v1
Checksum:iA47AEEE66E90BAF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105392 mRNA Translation: AAI05393.1
RefSeqiNP_001069362.1, NM_001075894.1
UniGeneiBt.45725

Genome annotation databases

GeneIDi527124
KEGGibta:527124

Similar proteinsi

Entry informationi

Entry nameiCDN2B_BOVIN
AccessioniPrimary (citable) accession number: Q2KJD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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