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Q2KJD7

- UBCP1_BOVIN

UniProt

Q2KJD7 - UBCP1_BOVIN

Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

UBLCP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Nuclear proteasome inhibitor UBLCP1
    Gene namesi
    Name:UBLCP1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    Nucleus By similarity
    Note: Colocalizes with nuclear proteasomes.By similarity

    GO - Cellular componenti

    1. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 318317Ubiquitin-like domain-containing CTD phosphatase 1PRO_0000242639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei117 – 1171N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ2KJD7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000011999.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJD7.
    SMRiQ2KJD7. Positions 1-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8179Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 294162FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 294162PhosphataseBy similarityAdd
    BLAST

    Domaini

    The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG310886.
    GeneTreeiENSGT00390000010107.
    HOGENOMiHOG000231279.
    HOVERGENiHBG080207.
    InParanoidiQ2KJD7.
    KOiK17618.
    OMAiELNPPRE.
    OrthoDBiEOG74TX01.
    TreeFamiTF323786.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2KJD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV    50
    KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVVNDFD 100
    IEDEVVEVEN REENLLKISR RVKEYKVEIL NPPREGKKLL VLDVDYTLFD 150
    HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS 200
    TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM 250
    FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF 300
    LDLNHKYWER YLSKKQGQ 318
    Length:318
    Mass (Da):36,805
    Last modified:March 7, 2006 - v1
    Checksum:i21CB4DB22C3B0E0F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105394 mRNA. Translation: AAI05395.1.
    RefSeqiNP_001039459.1. NM_001045994.1.
    UniGeneiBt.1089.

    Genome annotation databases

    EnsembliENSBTAT00000011999; ENSBTAP00000011999; ENSBTAG00000009103.
    GeneIDi508163.
    KEGGibta:508163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105394 mRNA. Translation: AAI05395.1 .
    RefSeqi NP_001039459.1. NM_001045994.1.
    UniGenei Bt.1089.

    3D structure databases

    ProteinModelPortali Q2KJD7.
    SMRi Q2KJD7. Positions 1-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000011999.

    Proteomic databases

    PRIDEi Q2KJD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000011999 ; ENSBTAP00000011999 ; ENSBTAG00000009103 .
    GeneIDi 508163.
    KEGGi bta:508163.

    Organism-specific databases

    CTDi 134510.

    Phylogenomic databases

    eggNOGi NOG310886.
    GeneTreei ENSGT00390000010107.
    HOGENOMi HOG000231279.
    HOVERGENi HBG080207.
    InParanoidi Q2KJD7.
    KOi K17618.
    OMAi ELNPPRE.
    OrthoDBi EOG74TX01.
    TreeFami TF323786.

    Miscellaneous databases

    NextBioi 20868387.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiUBCP1_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3