ID   AL7A1_BOVIN             Reviewed;         511 AA.
AC   Q2KJC9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase;
DE            Short=Alpha-AASA dehydrogenase;
DE            EC=1.2.1.31;
DE   AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenease;
DE            Short=P6c dehydrogenase;
DE   AltName: Full=Aldehyde dehydrogenase family 7 member A1;
DE   AltName: Full=Antiquitin-1;
GN   Name=ALDH7A1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-2-aminoadipate 6-semialdehyde + NAD(P)(+) +
CC       H(2)O = L-2-aminoadipate + NAD(P)H.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; BC105406; AAI05407.1; -; mRNA.
DR   IPI; IPI00715692; -.
DR   RefSeq; NP_001039434.2; -.
DR   UniGene; Bt.22086; -.
DR   SMR; Q2KJC9; 1-498, 2-499.
DR   Ensembl; ENSBTAG00000009646; Bos taurus.
DR   GeneID; 507477; -.
DR   KEGG; bta:507477; -.
DR   HOVERGEN; Q2KJC9; -.
DR   BRENDA; 1.2.1.31; 251.
DR   GO; GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase a...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   NAD; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    511       Alpha-aminoadipic semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000244567.
FT   NP_BIND     246    251       NAD (By similarity).
FT   ACT_SITE    268    268       Proton acceptor (By similarity).
FT   ACT_SITE    302    302       Nucleophile (By similarity).
FT   SITE        167    167       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   511 AA;  55379 MW;  26951EAAEE6F9505 CRC64;
     MSTLLINQPQ YAWLKELGLR EENDGVYNGS WGGRGEVITT YCPANNEPIA RVRQASMADY
     EETVEKAREA WSIWADVPAP KRGEVVRQIG DALREKIQVL GSLVSLEMGK ILVEGVGEVQ
     EYVDVCDYAV GLSRMIGGPI LPSERPGHAL IEQWNPVGLV GIITAFNFPV AVYGWNNAIA
     MICGNACLWK GAPTTSLISV AVTKIIAKVL EDNKLPGAIC SLTCGGADIG TAMAKDERVD
     LLSFTGSTQV GKQVALMVQE RFGRSLLELG GNNAIIAFED ADLSLVVPSA LFAAVGTAGQ
     RCTTARRLFL HESIHDEVVN RLKKAYAQIR VGNPWDSNVL YGPLHTKQAV SMFLGAVEEA
     KKEGGTVVYG GKVMDRPGNY VEPTIVTGLD HDASIVHTET FAPILYVFKF KNEDEVFAWN
     NEVKQGLSSS IFTKDMGRIF RWLGPKGSDC GIVNVNIPTS GAEIGGAFGG EKHTGGGRES
     GSDAWKQYMR RSTCTINYSK DLPLAQGIKF Q
//