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Q2KJC9 (AL7A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-aminoadipic semialdehyde dehydrogenase

Short name=Alpha-AASA dehydrogenase
EC=1.2.1.31
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1
EC=1.2.1.3
Antiquitin-1
Betaine aldehyde dehydrogenase
EC=1.2.1.8
Delta1-piperideine-6-carboxylate dehydrogenase
Short name=P6c dehydrogenase
Gene names
Name:ALDH7A1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism By similarity.

Catalytic activity

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Subunit structure

Homotetramer By similarity.

Subcellular location

Nucleus By similarity. Cytoplasmcytosol By similarity. Mitochondrion By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence caution

The sequence AAI05407.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Mitochondrion
Nucleus
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-aminoadipate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

betaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2626Mitochondrion Potential
Chain27 – 539513Alpha-aminoadipic semialdehyde dehydrogenase
PRO_0000244567

Regions

Nucleotide binding274 – 2796NAD By similarity

Sites

Active site2961Proton acceptor By similarity
Active site3301Nucleophile By similarity
Site1951Transition state stabilizer By similarity

Amino acid modifications

Modified residue941N6-acetyllysine; alternate By similarity
Modified residue941N6-succinyllysine; alternate By similarity
Modified residue4621N6-acetyllysine By similarity
Modified residue5001N6-acetyllysine By similarity
Modified residue5371N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KJC9 [UniParc].

Last modified April 20, 2010. Version 4.
Checksum: 3052D80937989DB4

FASTA53958,582
        10         20         30         40         50         60 
MWRVPGLLCV RVARKSKFSG SWNRPAAFMS TLLINQPQYA WLKELGLREE NDGVYNGSWG 

        70         80         90        100        110        120 
GRGEVITTYC PANNEPIARV RQASMADYEE TVEKAREAWS IWADVPAPKR GEVVRQIGDA 

       130        140        150        160        170        180 
LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDVCDYAVGL SRMIGGPILP SERPGHALIE 

       190        200        210        220        230        240 
QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNACLWKGA PTTSLISVAV TKIIAKVLED 

       250        260        270        280        290        300 
NKLPGAICSL TCGGADIGTA MAKDERVDLL SFTGSTQVGK QVALMVQERF GRSLLELGGN 

       310        320        330        340        350        360 
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFLHE SIHDEVVNRL KKAYAQIRVG 

       370        380        390        400        410        420 
NPWDSNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLDHD 

       430        440        450        460        470        480 
ASIVHTETFA PILYVFKFKN EDEVFAWNNE VKQGLSSSIF TKDMGRIFRW LGPKGSDCGI 

       490        500        510        520        530 
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Heart ventricle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC105406 mRNA. Translation: AAI05407.1. Different initiation.
RefSeqNP_001039434.2. NM_001045969.2.
UniGeneBt.22086.

3D structure databases

ProteinModelPortalQ2KJC9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000048297.

Proteomic databases

PaxDbQ2KJC9.
PRIDEQ2KJC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID507477.
KEGGbta:507477.

Organism-specific databases

CTD501.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271511.
HOVERGENHBG050485.
KOK14085.

Enzyme and pathway databases

UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868078.

Entry information

Entry nameAL7A1_BOVIN
AccessionPrimary (citable) accession number: Q2KJC9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 20, 2010
Last modified: March 19, 2014
This is version 65 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways