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Q2KJC9

- AL7A1_BOVIN

UniProt

Q2KJC9 - AL7A1_BOVIN

Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

ALDH7A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 4 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism By similarity.By similarity

    Catalytic activityi

    (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.
    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei195 – 1951Transition state stabilizerBy similarity
    Active sitei296 – 2961Proton acceptorPROSITE-ProRule annotation
    Active sitei330 – 3301NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi274 – 2796NADBy similarity

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
    Short name:
    Alpha-AASA dehydrogenase
    Alternative name(s):
    Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
    Antiquitin-1
    Betaine aldehyde dehydrogenase (EC:1.2.1.8)
    Delta1-piperideine-6-carboxylate dehydrogenase
    Short name:
    P6c dehydrogenase
    Gene namesi
    Name:ALDH7A1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytosol By similarity. Mitochondrion By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. mitochondrion Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
    BLAST
    Chaini27 – 539513Alpha-aminoadipic semialdehyde dehydrogenasePRO_0000244567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941N6-acetyllysine; alternateBy similarity
    Modified residuei94 – 941N6-succinyllysine; alternateBy similarity
    Modified residuei462 – 4621N6-acetyllysineBy similarity
    Modified residuei500 – 5001N6-acetyllysineBy similarity
    Modified residuei537 – 5371N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ2KJC9.
    PRIDEiQ2KJC9.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiQ2KJC9. 2 interactions.
    STRINGi9913.ENSBTAP00000048297.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271511.
    HOVERGENiHBG050485.
    KOiK14085.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2KJC9-1 [UniParc]FASTAAdd to Basket

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    MWRVPGLLCV RVARKSKFSG SWNRPAAFMS TLLINQPQYA WLKELGLREE    50
    NDGVYNGSWG GRGEVITTYC PANNEPIARV RQASMADYEE TVEKAREAWS 100
    IWADVPAPKR GEVVRQIGDA LREKIQVLGS LVSLEMGKIL VEGVGEVQEY 150
    VDVCDYAVGL SRMIGGPILP SERPGHALIE QWNPVGLVGI ITAFNFPVAV 200
    YGWNNAIAMI CGNACLWKGA PTTSLISVAV TKIIAKVLED NKLPGAICSL 250
    TCGGADIGTA MAKDERVDLL SFTGSTQVGK QVALMVQERF GRSLLELGGN 300
    NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFLHE SIHDEVVNRL 350
    KKAYAQIRVG NPWDSNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK 400
    VMDRPGNYVE PTIVTGLDHD ASIVHTETFA PILYVFKFKN EDEVFAWNNE 450
    VKQGLSSSIF TKDMGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK 500
    HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ 539
    Length:539
    Mass (Da):58,582
    Last modified:April 20, 2010 - v4
    Checksum:i3052D80937989DB4
    GO

    Sequence cautioni

    The sequence AAI05407.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105406 mRNA. Translation: AAI05407.1. Different initiation.
    RefSeqiNP_001039434.2. NM_001045969.2.
    UniGeneiBt.22086.

    Genome annotation databases

    GeneIDi507477.
    KEGGibta:507477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105406 mRNA. Translation: AAI05407.1 . Different initiation.
    RefSeqi NP_001039434.2. NM_001045969.2.
    UniGenei Bt.22086.

    3D structure databases

    ProteinModelPortali Q2KJC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q2KJC9. 2 interactions.
    STRINGi 9913.ENSBTAP00000048297.

    Proteomic databases

    PaxDbi Q2KJC9.
    PRIDEi Q2KJC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 507477.
    KEGGi bta:507477.

    Organism-specific databases

    CTDi 501.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271511.
    HOVERGENi HBG050485.
    KOi K14085.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .

    Miscellaneous databases

    NextBioi 20868078.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.

    Entry informationi

    Entry nameiAL7A1_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 67 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3