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Q2KJC9

- AL7A1_BOVIN

UniProt

Q2KJC9 - AL7A1_BOVIN

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Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene
ALDH7A1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism By similarity.

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei195 – 1951Transition state stabilizer By similarity
Active sitei296 – 2961Proton acceptor By similarity
Active sitei330 – 3301Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2796NAD By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
Short name:
Alpha-AASA dehydrogenase
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
Antiquitin-1
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Delta1-piperideine-6-carboxylate dehydrogenase
Short name:
P6c dehydrogenase
Gene namesi
Name:ALDH7A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasmcytosol By similarity. Mitochondrion By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. mitochondrion Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626Mitochondrion Reviewed predictionAdd
BLAST
Chaini27 – 539513Alpha-aminoadipic semialdehyde dehydrogenasePRO_0000244567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-acetyllysine; alternate By similarity
Modified residuei94 – 941N6-succinyllysine; alternate By similarity
Modified residuei462 – 4621N6-acetyllysine By similarity
Modified residuei500 – 5001N6-acetyllysine By similarity
Modified residuei537 – 5371N6-succinyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KJC9.
PRIDEiQ2KJC9.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048297.

Structurei

3D structure databases

ProteinModelPortaliQ2KJC9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271511.
HOVERGENiHBG050485.
KOiK14085.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJC9-1 [UniParc]FASTAAdd to Basket

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MWRVPGLLCV RVARKSKFSG SWNRPAAFMS TLLINQPQYA WLKELGLREE    50
NDGVYNGSWG GRGEVITTYC PANNEPIARV RQASMADYEE TVEKAREAWS 100
IWADVPAPKR GEVVRQIGDA LREKIQVLGS LVSLEMGKIL VEGVGEVQEY 150
VDVCDYAVGL SRMIGGPILP SERPGHALIE QWNPVGLVGI ITAFNFPVAV 200
YGWNNAIAMI CGNACLWKGA PTTSLISVAV TKIIAKVLED NKLPGAICSL 250
TCGGADIGTA MAKDERVDLL SFTGSTQVGK QVALMVQERF GRSLLELGGN 300
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFLHE SIHDEVVNRL 350
KKAYAQIRVG NPWDSNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK 400
VMDRPGNYVE PTIVTGLDHD ASIVHTETFA PILYVFKFKN EDEVFAWNNE 450
VKQGLSSSIF TKDMGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK 500
HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ 539
Length:539
Mass (Da):58,582
Last modified:April 20, 2010 - v4
Checksum:i3052D80937989DB4
GO

Sequence cautioni

The sequence AAI05407.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105406 mRNA. Translation: AAI05407.1. Different initiation.
RefSeqiNP_001039434.2. NM_001045969.2.
UniGeneiBt.22086.

Genome annotation databases

GeneIDi507477.
KEGGibta:507477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105406 mRNA. Translation: AAI05407.1 . Different initiation.
RefSeqi NP_001039434.2. NM_001045969.2.
UniGenei Bt.22086.

3D structure databases

ProteinModelPortali Q2KJC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000048297.

Proteomic databases

PaxDbi Q2KJC9.
PRIDEi Q2KJC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 507477.
KEGGi bta:507477.

Organism-specific databases

CTDi 501.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271511.
HOVERGENi HBG050485.
KOi K14085.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .

Miscellaneous databases

NextBioi 20868078.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiAL7A1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 20, 2010
Last modified: June 11, 2014
This is version 66 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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