Reviewed,
UniProtKB/Swiss-Prot Q2KJC9 (AL7A1_BOVIN)
Last modified
November 4, 2008.
Version 26.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Alpha-aminoadipic semialdehyde dehydrogenase Short name=Alpha-AASA dehydrogenase EC=1.2.1.31 Alternative name(s): Delta1-piperideine-6-carboxylate dehydrogenease Short name=P6c dehydrogenase Aldehyde dehydrogenase family 7 member A1 Antiquitin-1 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 511 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H. |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 511 | 510 | Alpha-aminoadipic semialdehyde dehydrogenase | PRO_0000244567 | |||||
Regions | |||||||||
| Nucleotide binding | 246 – 251 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 268 | 1 | Proton acceptor By similarity | ||||||
| Active site | 302 | 1 | Nucleophile By similarity | ||||||
| Site | 167 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle. |
Cross-references
Sequence databases | |
|---|---|
| BC105406 mRNA. Translation: AAI05407.1. | |
| RefSeq | NP_001039434.2. |
| UniGene | Bt.22086 |
3D structure databases | |
| SMR | Q2KJC9. Positions 1-498, 2-499. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000009646. Bos taurus. [Contig view] |
| GeneID | 507477. |
Phylogenomic databases | |
| HOVERGEN | Q2KJC9. |
Family and domain databases | |
| InterPro | IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AL7A1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q2KJC9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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