Q2KJC9 (AL7A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase
Short name=Alpha-AASA dehydrogenase
EC=1.2.1.31

Alternative name(s):
Aldehyde dehydrogenase family 7 member A1
EC=1.2.1.3
Antiquitin-1
Betaine aldehyde dehydrogenase
EC=1.2.1.8
Delta1-piperideine-6-carboxylate dehydrogenase
Short name=P6c dehydrogenase

Gene names

Name:

ALDH7A1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism By similarity.
Catalytic activity	(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H. Betaine aldehyde + NAD+ + H2O = betaine + NADH. An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit structure	Homotetramer By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm › cytosol By similarity. Mitochondrion By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Sequence caution	The sequence AAI05407.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion Nucleus
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 26	26	Mitochondrion Potential
	Chain	27 – 539	513	Alpha-aminoadipic semialdehyde dehydrogenase		PRO_0000244567
Regions
	Nucleotide binding	274 – 279	6	NAD By similarity
Sites
	Active site	296	1	Proton acceptor By similarity
	Active site	330	1	Nucleophile By similarity
	Site	195	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KJC9 [UniParc]. Last modified April 20, 2010. Version 4. Checksum: 3052D80937989DB4	FASTA	539	58,582
	10 20 30 40 50 60 MWRVPGLLCV RVARKSKFSG SWNRPAAFMS TLLINQPQYA WLKELGLREE NDGVYNGSWG 70 80 90 100 110 120 GRGEVITTYC PANNEPIARV RQASMADYEE TVEKAREAWS IWADVPAPKR GEVVRQIGDA 130 140 150 160 170 180 LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDVCDYAVGL SRMIGGPILP SERPGHALIE 190 200 210 220 230 240 QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNACLWKGA PTTSLISVAV TKIIAKVLED 250 260 270 280 290 300 NKLPGAICSL TCGGADIGTA MAKDERVDLL SFTGSTQVGK QVALMVQERF GRSLLELGGN 310 320 330 340 350 360 NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFLHE SIHDEVVNRL KKAYAQIRVG 370 380 390 400 410 420 NPWDSNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLDHD 430 440 450 460 470 480 ASIVHTETFA PILYVFKFKN EDEVFAWNNE VKQGLSSSIF TKDMGRIFRW LGPKGSDCGI 490 500 510 520 530 VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105406 mRNA. Translation: AAI05407.1. Different initiation.
IPI	IPI00908241.
RefSeq	NP_001039434.2. NM_001045969.2.
UniGene	Bt.22086.
3D structure databases
ProteinModelPortal	Q2KJC9.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000048297.
Proteomic databases
PaxDb	Q2KJC9.
PRIDE	Q2KJC9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	507477.
KEGG	bta:507477.
Organism-specific databases
CTD	501.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271511.
HOVERGEN	HBG050485.
KO	K14085.
Enzyme and pathway databases
UniPathway	UPA00529; UER00386.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20868078.

Entry information

Entry name

AL7A1_BOVIN

Accession

Primary (citable) accession number: Q2KJC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 58 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program