Reviewed, UniProtKB/Swiss-Prot Q2KJC9 (AL7A1_BOVIN)

Names and origin

Protein names

Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase
      Short name=Alpha-AASA dehydrogenase
    EC=1.2.1.31
Alternative name(s):
    Delta1-piperideine-6-carboxylate dehydrogenease
      Short name=P6c dehydrogenase
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1

Gene names

Name:

ALDH7A1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 511	510	Alpha-aminoadipic semialdehyde dehydrogenase		PRO_0000244567
Regions
	Nucleotide binding	246 – 251	6	NAD By similarity
Sites
	Active site	268	1	Proton acceptor By similarity
	Active site	302	1	Nucleophile By similarity
	Site	167	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KJC9-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 26951EAAEE6F9505	FASTA	511	55,379
	10 20 30 40 50 60 MSTLLINQPQ YAWLKELGLR EENDGVYNGS WGGRGEVITT YCPANNEPIA RVRQASMADY 70 80 90 100 110 120 EETVEKAREA WSIWADVPAP KRGEVVRQIG DALREKIQVL GSLVSLEMGK ILVEGVGEVQ 130 140 150 160 170 180 EYVDVCDYAV GLSRMIGGPI LPSERPGHAL IEQWNPVGLV GIITAFNFPV AVYGWNNAIA 190 200 210 220 230 240 MICGNACLWK GAPTTSLISV AVTKIIAKVL EDNKLPGAIC SLTCGGADIG TAMAKDERVD 250 260 270 280 290 300 LLSFTGSTQV GKQVALMVQE RFGRSLLELG GNNAIIAFED ADLSLVVPSA LFAAVGTAGQ 310 320 330 340 350 360 RCTTARRLFL HESIHDEVVN RLKKAYAQIR VGNPWDSNVL YGPLHTKQAV SMFLGAVEEA 370 380 390 400 410 420 KKEGGTVVYG GKVMDRPGNY VEPTIVTGLD HDASIVHTET FAPILYVFKF KNEDEVFAWN 430 440 450 460 470 480 NEVKQGLSSS IFTKDMGRIF RWLGPKGSDC GIVNVNIPTS GAEIGGAFGG EKHTGGGRES 490 500 510 GSDAWKQYMR RSTCTINYSK DLPLAQGIKF Q

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC105406 mRNA. Translation: AAI05407.1.
RefSeq	NP_001039434.2.
UniGene	Bt.22086
3D structure databases
SMR	Q2KJC9. Positions 1-498, 2-499.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000009646. Bos taurus. [Contig view]
GeneID	507477.
Phylogenomic databases
HOVERGEN	Q2KJC9.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_BOVIN

Accession

Primary (citable) accession number: Q2KJC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 23, 2007
Last modified:	November 4, 2008
This is version 26 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)