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Q2KJC8

- FKBP9_BOVIN

UniProt

Q2KJC8 - FKBP9_BOVIN

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Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

FKBP9

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi505 – 517131PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi550 – 561122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. FK506 binding Source: RefGenome
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
FK506-binding protein 9
Short name:
FKBP-9
Rotamase
Gene namesi
Name:FKBP9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 574548Peptidyl-prolyl cis-trans isomerase FKBP9PRO_0000239738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

ExpressionAtlasiQ2KJC8. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ2KJC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 14689PPIase FKBP-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini170 – 25889PPIase FKBP-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini282 – 36988PPIase FKBP-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini393 – 48189PPIase FKBP-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini492 – 52736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini537 – 57236EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi571 – 5744Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ2KJC8.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG7T1R9S.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIRARSWRP PPPPLLLLLL WVTGQAAPVA GLGLGSDSEL QIERRFVPEE
60 70 80 90 100
CPRTVRSGDF VRYHYVGTFP DGQKFDSSYD RDSTFNVFVG KGQLIAGMDQ
110 120 130 140 150
ALVGMCVNER RFVKIPPKLA YGSDGVSGVI PPDSVLHFDV LLMDIWNSED
160 170 180 190 200
QVQIHTYFKP PSCPRTIQVS DFVRYHYNGT FLDGTLFDSS HNRMKTYDTY
210 220 230 240 250
VGIGWLIPGM DKGLLGMCVG EKRIITIPPF LAYGEDGDGK DIPGQASLVF
260 270 280 290 300
DVALLDLHNP KDGISIENKV VPENCERRSQ SGDFLRYHYN GTLLDGTFFD
310 320 330 340 350
SSYSRNRTFD TYIGQGYVIP GIDEGLLGVC IGEKRRIVVP PHLGYGEEGR
360 370 380 390 400
GNIPGSAVLV FDIHVIDFHN PSDSISITSH YKPPDCSVLS KKGDYLKYHY
410 420 430 440 450
NASLLDGTLL DSTWNLGKTY NIVLGFGQVV LGMDMGLREM CVGEKRTVII
460 470 480 490 500
PPHLGYGEAG VDGEVPGSAV LVFDIELLEL VAGLPEGYMF VWNGEVSANL
510 520 530 540 550
FEEIDKDGDG EVLLEEFSEY IHAQVASGKG KLAPGFDAEM IVKNMFTNQD
560 570
RNGDGKVTAE EFKLKDQETK HDEL
Length:574
Mass (Da):63,535
Last modified:March 7, 2006 - v1
Checksum:i64F34A83AB3BB51A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105407 mRNA. Translation: AAI05408.1.
RefSeqiNP_001039837.1. NM_001046372.2.
UniGeneiBt.51759.

Genome annotation databases

EnsembliENSBTAT00000033703; ENSBTAP00000033613; ENSBTAG00000016707.
GeneIDi534182.
KEGGibta:534182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105407 mRNA. Translation: AAI05408.1 .
RefSeqi NP_001039837.1. NM_001046372.2.
UniGenei Bt.51759.

3D structure databases

ProteinModelPortali Q2KJC8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000033703 ; ENSBTAP00000033613 ; ENSBTAG00000016707 .
GeneIDi 534182.
KEGGi bta:534182.

Organism-specific databases

CTDi 11328.

Phylogenomic databases

eggNOGi COG0545.
GeneTreei ENSGT00530000062784.
HOGENOMi HOG000230960.
HOVERGENi HBG051620.
InParanoidi Q2KJC8.
KOi K09575.
OMAi EMIVKNM.
OrthoDBi EOG7T1R9S.
TreeFami TF105296.

Miscellaneous databases

NextBioi 20876299.

Gene expression databases

ExpressionAtlasi Q2KJC8. baseline.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 4 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiFKBP9_BOVIN
AccessioniPrimary (citable) accession number: Q2KJC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3