Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q2KJC8

- FKBP9_BOVIN

UniProt

Q2KJC8 - FKBP9_BOVIN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

FKBP9

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by FK506.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi505 – 517131PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi550 – 561122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl
    2. FK506 binding Source: RefGenome
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
    Short name:
    PPIase FKBP9
    Alternative name(s):
    FK506-binding protein 9
    Short name:
    FKBP-9
    Rotamase
    Gene namesi
    Name:FKBP9
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 574548Peptidyl-prolyl cis-trans isomerase FKBP9PRO_0000239738Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 14689PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini170 – 25889PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini282 – 36988PPIase FKBP-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini393 – 48189PPIase FKBP-type 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini492 – 52736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini537 – 57236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi571 – 5744Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    GeneTreeiENSGT00530000062784.
    HOGENOMiHOG000230960.
    HOVERGENiHBG051620.
    InParanoidiQ2KJC8.
    KOiK09575.
    OMAiEMIVKNM.
    OrthoDBiEOG7T1R9S.
    TreeFamiTF105296.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 4 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2KJC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIRARSWRP PPPPLLLLLL WVTGQAAPVA GLGLGSDSEL QIERRFVPEE    50
    CPRTVRSGDF VRYHYVGTFP DGQKFDSSYD RDSTFNVFVG KGQLIAGMDQ 100
    ALVGMCVNER RFVKIPPKLA YGSDGVSGVI PPDSVLHFDV LLMDIWNSED 150
    QVQIHTYFKP PSCPRTIQVS DFVRYHYNGT FLDGTLFDSS HNRMKTYDTY 200
    VGIGWLIPGM DKGLLGMCVG EKRIITIPPF LAYGEDGDGK DIPGQASLVF 250
    DVALLDLHNP KDGISIENKV VPENCERRSQ SGDFLRYHYN GTLLDGTFFD 300
    SSYSRNRTFD TYIGQGYVIP GIDEGLLGVC IGEKRRIVVP PHLGYGEEGR 350
    GNIPGSAVLV FDIHVIDFHN PSDSISITSH YKPPDCSVLS KKGDYLKYHY 400
    NASLLDGTLL DSTWNLGKTY NIVLGFGQVV LGMDMGLREM CVGEKRTVII 450
    PPHLGYGEAG VDGEVPGSAV LVFDIELLEL VAGLPEGYMF VWNGEVSANL 500
    FEEIDKDGDG EVLLEEFSEY IHAQVASGKG KLAPGFDAEM IVKNMFTNQD 550
    RNGDGKVTAE EFKLKDQETK HDEL 574
    Length:574
    Mass (Da):63,535
    Last modified:March 7, 2006 - v1
    Checksum:i64F34A83AB3BB51A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105407 mRNA. Translation: AAI05408.1.
    RefSeqiNP_001039837.1. NM_001046372.2.
    UniGeneiBt.51759.

    Genome annotation databases

    EnsembliENSBTAT00000033703; ENSBTAP00000033613; ENSBTAG00000016707.
    GeneIDi534182.
    KEGGibta:534182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105407 mRNA. Translation: AAI05408.1 .
    RefSeqi NP_001039837.1. NM_001046372.2.
    UniGenei Bt.51759.

    3D structure databases

    ProteinModelPortali Q2KJC8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000033703 ; ENSBTAP00000033613 ; ENSBTAG00000016707 .
    GeneIDi 534182.
    KEGGi bta:534182.

    Organism-specific databases

    CTDi 11328.

    Phylogenomic databases

    eggNOGi COG0545.
    GeneTreei ENSGT00530000062784.
    HOGENOMi HOG000230960.
    HOVERGENi HBG051620.
    InParanoidi Q2KJC8.
    KOi K09575.
    OMAi EMIVKNM.
    OrthoDBi EOG7T1R9S.
    TreeFami TF105296.

    Miscellaneous databases

    NextBioi 20876299.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 4 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.

    Entry informationi

    Entry nameiFKBP9_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3