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Q2KJC8

- FKBP9_BOVIN

UniProt

Q2KJC8 - FKBP9_BOVIN

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Protein
Peptidyl-prolyl cis-trans isomerase FKBP9
Gene
FKBP9
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis By similarity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi505 – 517131 Reviewed prediction
Add
BLAST
Calcium bindingi550 – 561122 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. calcium ion binding Source: Ensembl
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
FK506-binding protein 9
Short name:
FKBP-9
Rotamase
Gene namesi
Name:FKBP9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 574548Peptidyl-prolyl cis-trans isomerase FKBP9
PRO_0000239738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi306 – 3061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated By similarity.

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2KJC8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 14689PPIase FKBP-type 1
Add
BLAST
Domaini170 – 25889PPIase FKBP-type 2
Add
BLAST
Domaini282 – 36988PPIase FKBP-type 3
Add
BLAST
Domaini393 – 48189PPIase FKBP-type 4
Add
BLAST
Domaini492 – 52736EF-hand 1
Add
BLAST
Domaini537 – 57236EF-hand 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi571 – 5744Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ2KJC8.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG7T1R9S.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJC8-1 [UniParc]FASTAAdd to Basket

« Hide

MAIRARSWRP PPPPLLLLLL WVTGQAAPVA GLGLGSDSEL QIERRFVPEE    50
CPRTVRSGDF VRYHYVGTFP DGQKFDSSYD RDSTFNVFVG KGQLIAGMDQ 100
ALVGMCVNER RFVKIPPKLA YGSDGVSGVI PPDSVLHFDV LLMDIWNSED 150
QVQIHTYFKP PSCPRTIQVS DFVRYHYNGT FLDGTLFDSS HNRMKTYDTY 200
VGIGWLIPGM DKGLLGMCVG EKRIITIPPF LAYGEDGDGK DIPGQASLVF 250
DVALLDLHNP KDGISIENKV VPENCERRSQ SGDFLRYHYN GTLLDGTFFD 300
SSYSRNRTFD TYIGQGYVIP GIDEGLLGVC IGEKRRIVVP PHLGYGEEGR 350
GNIPGSAVLV FDIHVIDFHN PSDSISITSH YKPPDCSVLS KKGDYLKYHY 400
NASLLDGTLL DSTWNLGKTY NIVLGFGQVV LGMDMGLREM CVGEKRTVII 450
PPHLGYGEAG VDGEVPGSAV LVFDIELLEL VAGLPEGYMF VWNGEVSANL 500
FEEIDKDGDG EVLLEEFSEY IHAQVASGKG KLAPGFDAEM IVKNMFTNQD 550
RNGDGKVTAE EFKLKDQETK HDEL 574
Length:574
Mass (Da):63,535
Last modified:March 7, 2006 - v1
Checksum:i64F34A83AB3BB51A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105407 mRNA. Translation: AAI05408.1.
RefSeqiNP_001039837.1. NM_001046372.2.
UniGeneiBt.51759.

Genome annotation databases

EnsembliENSBTAT00000033703; ENSBTAP00000033613; ENSBTAG00000016707.
GeneIDi534182.
KEGGibta:534182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105407 mRNA. Translation: AAI05408.1 .
RefSeqi NP_001039837.1. NM_001046372.2.
UniGenei Bt.51759.

3D structure databases

ProteinModelPortali Q2KJC8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000033703 ; ENSBTAP00000033613 ; ENSBTAG00000016707 .
GeneIDi 534182.
KEGGi bta:534182.

Organism-specific databases

CTDi 11328.

Phylogenomic databases

eggNOGi COG0545.
GeneTreei ENSGT00530000062784.
HOGENOMi HOG000230960.
HOVERGENi HBG051620.
InParanoidi Q2KJC8.
KOi K09575.
OMAi EMIVKNM.
OrthoDBi EOG7T1R9S.
TreeFami TF105296.

Miscellaneous databases

NextBioi 20876299.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 4 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiFKBP9_BOVIN
AccessioniPrimary (citable) accession number: Q2KJC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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