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Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

FKBP9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi505 – 5171PROSITE-ProRule annotationAdd BLAST13
Calcium bindingi550 – 5612PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
FK506-binding protein 9
Short name:
FKBP-9
Rotamase
Gene namesi
Name:FKBP9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

  • Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000023973827 – 574Peptidyl-prolyl cis-trans isomerase FKBP9Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1
Glycosylationi401N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2KJC8.
PeptideAtlasiQ2KJC8.
PRIDEiQ2KJC8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016707.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033613.

Structurei

3D structure databases

ProteinModelPortaliQ2KJC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 146PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini170 – 258PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST89
Domaini282 – 369PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST88
Domaini393 – 481PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST89
Domaini492 – 527EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini537 – 572EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi571 – 574Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ2KJC8.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG091G02W1.
TreeFamiTF105296.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRARSWRP PPPPLLLLLL WVTGQAAPVA GLGLGSDSEL QIERRFVPEE
60 70 80 90 100
CPRTVRSGDF VRYHYVGTFP DGQKFDSSYD RDSTFNVFVG KGQLIAGMDQ
110 120 130 140 150
ALVGMCVNER RFVKIPPKLA YGSDGVSGVI PPDSVLHFDV LLMDIWNSED
160 170 180 190 200
QVQIHTYFKP PSCPRTIQVS DFVRYHYNGT FLDGTLFDSS HNRMKTYDTY
210 220 230 240 250
VGIGWLIPGM DKGLLGMCVG EKRIITIPPF LAYGEDGDGK DIPGQASLVF
260 270 280 290 300
DVALLDLHNP KDGISIENKV VPENCERRSQ SGDFLRYHYN GTLLDGTFFD
310 320 330 340 350
SSYSRNRTFD TYIGQGYVIP GIDEGLLGVC IGEKRRIVVP PHLGYGEEGR
360 370 380 390 400
GNIPGSAVLV FDIHVIDFHN PSDSISITSH YKPPDCSVLS KKGDYLKYHY
410 420 430 440 450
NASLLDGTLL DSTWNLGKTY NIVLGFGQVV LGMDMGLREM CVGEKRTVII
460 470 480 490 500
PPHLGYGEAG VDGEVPGSAV LVFDIELLEL VAGLPEGYMF VWNGEVSANL
510 520 530 540 550
FEEIDKDGDG EVLLEEFSEY IHAQVASGKG KLAPGFDAEM IVKNMFTNQD
560 570
RNGDGKVTAE EFKLKDQETK HDEL
Length:574
Mass (Da):63,535
Last modified:March 7, 2006 - v1
Checksum:i64F34A83AB3BB51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105407 mRNA. Translation: AAI05408.1.
RefSeqiNP_001039837.1. NM_001046372.2.
UniGeneiBt.51759.

Genome annotation databases

EnsembliENSBTAT00000033703; ENSBTAP00000033613; ENSBTAG00000016707.
GeneIDi534182.
KEGGibta:534182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105407 mRNA. Translation: AAI05408.1.
RefSeqiNP_001039837.1. NM_001046372.2.
UniGeneiBt.51759.

3D structure databases

ProteinModelPortaliQ2KJC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033613.

Proteomic databases

PaxDbiQ2KJC8.
PeptideAtlasiQ2KJC8.
PRIDEiQ2KJC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000033703; ENSBTAP00000033613; ENSBTAG00000016707.
GeneIDi534182.
KEGGibta:534182.

Organism-specific databases

CTDi11328.

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ2KJC8.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG091G02W1.
TreeFamiTF105296.

Gene expression databases

BgeeiENSBTAG00000016707.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP9_BOVIN
AccessioniPrimary (citable) accession number: Q2KJC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.