Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q2KJC8 (FKBP9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9
Short name=PPIase FKBP9
EC=5.2.1.8
Alternative name(s):
FK506-binding protein 9
Short name=FKBP-9
Rotamase
Gene names
Name:FKBP9
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by FK506 By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Contains 2 EF-hand domains.

Contains 4 PPIase FKBP-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 574548Peptidyl-prolyl cis-trans isomerase FKBP9
PRO_0000239738

Regions

Domain58 – 14689PPIase FKBP-type 1
Domain170 – 25889PPIase FKBP-type 2
Domain282 – 36988PPIase FKBP-type 3
Domain393 – 48189PPIase FKBP-type 4
Domain492 – 52736EF-hand 1
Domain537 – 57236EF-hand 2
Calcium binding505 – 517131 Potential
Calcium binding550 – 561122 Potential
Motif571 – 5744Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2KJC8 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 64F34A83AB3BB51A

FASTA57463,535
        10         20         30         40         50         60 
MAIRARSWRP PPPPLLLLLL WVTGQAAPVA GLGLGSDSEL QIERRFVPEE CPRTVRSGDF 

        70         80         90        100        110        120 
VRYHYVGTFP DGQKFDSSYD RDSTFNVFVG KGQLIAGMDQ ALVGMCVNER RFVKIPPKLA 

       130        140        150        160        170        180 
YGSDGVSGVI PPDSVLHFDV LLMDIWNSED QVQIHTYFKP PSCPRTIQVS DFVRYHYNGT 

       190        200        210        220        230        240 
FLDGTLFDSS HNRMKTYDTY VGIGWLIPGM DKGLLGMCVG EKRIITIPPF LAYGEDGDGK 

       250        260        270        280        290        300 
DIPGQASLVF DVALLDLHNP KDGISIENKV VPENCERRSQ SGDFLRYHYN GTLLDGTFFD 

       310        320        330        340        350        360 
SSYSRNRTFD TYIGQGYVIP GIDEGLLGVC IGEKRRIVVP PHLGYGEEGR GNIPGSAVLV 

       370        380        390        400        410        420 
FDIHVIDFHN PSDSISITSH YKPPDCSVLS KKGDYLKYHY NASLLDGTLL DSTWNLGKTY 

       430        440        450        460        470        480 
NIVLGFGQVV LGMDMGLREM CVGEKRTVII PPHLGYGEAG VDGEVPGSAV LVFDIELLEL 

       490        500        510        520        530        540 
VAGLPEGYMF VWNGEVSANL FEEIDKDGDG EVLLEEFSEY IHAQVASGKG KLAPGFDAEM 

       550        560        570 
IVKNMFTNQD RNGDGKVTAE EFKLKDQETK HDEL

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Heart ventricle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC105407 mRNA. Translation: AAI05408.1.
IPIIPI00693278.
RefSeqNP_001039837.1. NM_001046372.2.
UniGeneBt.51759.

3D structure databases

ProteinModelPortalQ2KJC8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000033703; ENSBTAP00000033613; ENSBTAG00000016707.
GeneID534182.
KEGGbta:534182.

Organism-specific databases

CTD11328.

Phylogenomic databases

eggNOGCOG0545.
GeneTreeENSGT00530000062784.
HOGENOMHOG000230960.
HOVERGENHBG051620.
InParanoidQ2KJC8.
KOK09575.
OMACPRTIQV.
OrthoDBEOG4RR6GZ.

Gene expression databases

ArrayExpressQ2KJC8.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876299.

Entry information

Entry nameFKBP9_BOVIN
AccessionPrimary (citable) accession number: Q2KJC8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents