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Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

FKBP9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi505 – 5171PROSITE-ProRule annotationAdd BLAST13
Calcium bindingi550 – 5612PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
FK506-binding protein 9
Short name:
FKBP-9
Rotamase
Gene namesi
Name:FKBP9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:29027 FKBP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000023973827 – 574Peptidyl-prolyl cis-trans isomerase FKBP9Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2KJC8
PeptideAtlasiQ2KJC8
PRIDEiQ2KJC8

Expressioni

Gene expression databases

BgeeiENSBTAG00000016707

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033613

Structurei

3D structure databases

ProteinModelPortaliQ2KJC8
SMRiQ2KJC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 146PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini170 – 258PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST89
Domaini282 – 369PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST88
Domaini393 – 481PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST89
Domaini492 – 527EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini537 – 572EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi571 – 574Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000230960
HOVERGENiHBG051620
InParanoidiQ2KJC8
KOiK09575
OMAiEMIVKNM
OrthoDBiEOG091G02W1
TreeFamiTF105296

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 7 hits
PfamiView protein in Pfam
PF00254 FKBP_C, 4 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRARSWRP PPPPLLLLLL WVTGQAAPVA GLGLGSDSEL QIERRFVPEE
60 70 80 90 100
CPRTVRSGDF VRYHYVGTFP DGQKFDSSYD RDSTFNVFVG KGQLIAGMDQ
110 120 130 140 150
ALVGMCVNER RFVKIPPKLA YGSDGVSGVI PPDSVLHFDV LLMDIWNSED
160 170 180 190 200
QVQIHTYFKP PSCPRTIQVS DFVRYHYNGT FLDGTLFDSS HNRMKTYDTY
210 220 230 240 250
VGIGWLIPGM DKGLLGMCVG EKRIITIPPF LAYGEDGDGK DIPGQASLVF
260 270 280 290 300
DVALLDLHNP KDGISIENKV VPENCERRSQ SGDFLRYHYN GTLLDGTFFD
310 320 330 340 350
SSYSRNRTFD TYIGQGYVIP GIDEGLLGVC IGEKRRIVVP PHLGYGEEGR
360 370 380 390 400
GNIPGSAVLV FDIHVIDFHN PSDSISITSH YKPPDCSVLS KKGDYLKYHY
410 420 430 440 450
NASLLDGTLL DSTWNLGKTY NIVLGFGQVV LGMDMGLREM CVGEKRTVII
460 470 480 490 500
PPHLGYGEAG VDGEVPGSAV LVFDIELLEL VAGLPEGYMF VWNGEVSANL
510 520 530 540 550
FEEIDKDGDG EVLLEEFSEY IHAQVASGKG KLAPGFDAEM IVKNMFTNQD
560 570
RNGDGKVTAE EFKLKDQETK HDEL
Length:574
Mass (Da):63,535
Last modified:March 7, 2006 - v1
Checksum:i64F34A83AB3BB51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105407 mRNA Translation: AAI05408.1
RefSeqiNP_001039837.1, NM_001046372.2
UniGeneiBt.51759

Genome annotation databases

EnsembliENSBTAT00000033703; ENSBTAP00000033613; ENSBTAG00000016707
GeneIDi534182
KEGGibta:534182

Similar proteinsi

Entry informationi

Entry nameiFKBP9_BOVIN
AccessioniPrimary (citable) accession number: Q2KJC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health