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Protein

Carnitine O-palmitoyltransferase 2, mitochondrial

Gene

CPT2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei372Proton acceptorBy similarity1
Binding sitei486CarnitineBy similarity1
Binding sitei488CarnitineBy similarity1
Binding sitei499CarnitineBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 2, mitochondrial (EC:2.3.1.21)
Alternative name(s):
Carnitine palmitoyltransferase II
Short name:
CPT II
Gene namesi
Name:CPT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 178Mitochondrial matrixBy similarityAdd BLAST153
Intramembranei179 – 208Note=Mitochondrial inner membraneBy similarityAdd BLAST30
Topological domaini209 – 658Mitochondrial matrixBy similarityAdd BLAST450

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000023965926 – 658Carnitine O-palmitoyltransferase 2, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-succinyllysineBy similarity1
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei85N6-succinyllysineBy similarity1
Modified residuei239N6-acetyllysine; alternateBy similarity1
Modified residuei239N6-succinyllysine; alternateBy similarity1
Modified residuei418N6-acetyllysine; alternateBy similarity1
Modified residuei418N6-succinyllysine; alternateBy similarity1
Modified residuei424N6-succinyllysineBy similarity1
Modified residuei439N6-succinyllysineBy similarity1
Modified residuei510N6-acetyllysine; alternateBy similarity1
Modified residuei510N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KJB7.
PeptideAtlasiQ2KJB7.
PRIDEiQ2KJB7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019505.

Structurei

3D structure databases

ProteinModelPortaliQ2KJB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni452 – 464Coenzyme A bindingBy similarityAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3719. Eukaryota.
ENOG410XNZ9. LUCA.
HOGENOMiHOG000007446.
HOVERGENiHBG098001.
InParanoidiQ2KJB7.
KOiK08766.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 2 hits.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVARLLLRSW SRGLAVGPGA PCRPLSTGFE PSQYLQRSIV PTMHYQDSLP
60 70 80 90 100
RLPIPKLEDT IRRYLSAQKP LLDDSQFRKT EQLCKSFETG IGKELHEQLV
110 120 130 140 150
TQDKQNKHTS YISGPWFDMY LTARDPVVLN FNPFISFNPD PKSEYNDQLT
160 170 180 190 200
RATNMTVSAI RFLKTLRADL LEPEVFHLNP AKSDTDTFKR FIRFVPSFLS
210 220 230 240 250
WYGAYLVNAY PLDMSQYYRL FNSTRLPRPH RDELFTDDKA RHLLVLRKGH
260 270 280 290 300
FYIFDVLDQD GNIVSASEIQ AHLKYILSDN SPAPEFPLSY LTSENRDIWA
310 320 330 340 350
ELRQRLVSGG NEATLGKVDS AVFCLCLDDF PIRDFVHLSH SMLHGDGTNR
360 370 380 390 400
WFDKSFNLII AKDGTAAIHF EHAWGDGVAV LRFFNEVFKD STQAPAITPQ
410 420 430 440 450
SQPASTDSSV AVQKLNFKLS DALKTGISAA KEKFDATVKS LTIDYIRFQR
460 470 480 490 500
GGREFLKKQK LSPDSMAQLA FQMAFLRQYG QTVATYESCS TAAFKHGRTE
510 520 530 540 550
TIRPASIFTK TCSEAFVREP SKYSAGELQQ MMAKCSTYHN QLTREAAMGQ
560 570 580 590 600
GFDRHLFALR YLAAARGISM PELFLDPAYR QINHNILSTS TLSSPAVNIG
610 620 630 640 650
CFAPVVPDGF GIGYSVQDNW IGCNVSAYQS RNAREFLQCV EKALEDMFDA

LEGKMIKT
Length:658
Mass (Da):74,483
Last modified:March 7, 2006 - v1
Checksum:i97B7715788BABD4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105423 mRNA. Translation: AAI05424.1.
RefSeqiNP_001039354.1. NM_001045889.2.
UniGeneiBt.1065.

Genome annotation databases

GeneIDi504502.
KEGGibta:504502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105423 mRNA. Translation: AAI05424.1.
RefSeqiNP_001039354.1. NM_001045889.2.
UniGeneiBt.1065.

3D structure databases

ProteinModelPortaliQ2KJB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019505.

Proteomic databases

PaxDbiQ2KJB7.
PeptideAtlasiQ2KJB7.
PRIDEiQ2KJB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504502.
KEGGibta:504502.

Organism-specific databases

CTDi1376.

Phylogenomic databases

eggNOGiKOG3719. Eukaryota.
ENOG410XNZ9. LUCA.
HOGENOMiHOG000007446.
HOVERGENiHBG098001.
InParanoidiQ2KJB7.
KOiK08766.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 2 hits.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPT2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.