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Protein

Nostrin

Gene

NOSTRIN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.By similarity

GO - Biological processi

Keywordsi

Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Nostrin
Alternative name(s):
Nitric oxide synthase trafficker
eNOS trafficking inducer
Gene namesi
Name:NOSTRIN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002890881 – 505NostrinAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KJB5.
PRIDEiQ2KJB5.

Expressioni

Tissue specificityi

Present in pulmonary arterial endothelial cells (at protein level).1 Publication

Interactioni

Subunit structurei

Homotrimer. Interacts with DAB2. Interacts with NOS3, DNM2, WASL and CAV1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013682.

Structurei

3D structure databases

ProteinModelPortaliQ2KJB5.
SMRiQ2KJB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 260F-BARPROSITE-ProRule annotationAdd BLAST260
Domaini437 – 496SH3PROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili101 – 128Sequence analysisAdd BLAST28
Coiled coili160 – 222Sequence analysisAdd BLAST63
Coiled coili295 – 332Sequence analysisAdd BLAST38

Domaini

The SH3 domain mediates interaction with NOS3, DNM2 and WASL.By similarity
The F-BAR domain is necessary for membrane targeting.By similarity

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG4429. Eukaryota.
ENOG410ZDFS. LUCA.
HOGENOMiHOG000113830.
HOVERGENiHBG101730.
InParanoidiQ2KJB5.
KOiK20126.

Family and domain databases

CDDicd11823. SH3_Nostrin. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR031160. F_BAR.
IPR001060. FCH_dom.
IPR011072. HR1_rho-bd.
IPR028535. Nostrin.
IPR035656. Nostrin_SH3.
IPR001452. SH3_domain.
PANTHERiPTHR14167:SF36. PTHR14167:SF36. 1 hit.
PfamiView protein in Pfam
PF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
SSF46585. SSF46585. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS51741. F_BAR. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KJB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDPLTDCSY NKVYKNLKEF SQNGEDFCKQ ITSILQQRAN LEINYAKGLQ
60 70 80 90 100
KLATKLSKTL QSAKKNCLVS AWAWVSEGMK SAGDLHQKLG KAIELEAIKP
110 120 130 140 150
AHQVLSAHEK KRKSLENEVE KTANLVISNW NQQIKAKKKL MVSTKKHEAL
160 170 180 190 200
FHLVESSKQI TTEKEKQKLL NKLKKSTEKL SKEDENYYQK NVASCSTRLK
210 220 230 240 250
WENTLENCFQ SILELEKERI QLLCNNLNQY SQHISVFGQT LTTCHTQIHC
260 270 280 290 300
AISKIDIEKD IQALMEETTV SSTENKSEFL LTDYFEEDPK NAMSKERQTS
310 320 330 340 350
SIKSKLLRLQ KDIEKASRDQ EGLERMLRAY SSHSSFSDSE SKKSTAALMD
360 370 380 390 400
ENSLKLDLLQ ANSYKLSSVL AELEQRPQPN HPCSNSIFKW KEKQTHSSVK
410 420 430 440 450
ISRPVLMKRL ENVVNRASSD GQRIPSPSST ASGVTQLGNG LCKALYPFQA
460 470 480 490 500
RQDDELDLEK GDIVTIHKKK DEGWWFGSLK GKKGHFPAAY VEELPLNAGD

TASQA
Length:505
Mass (Da):57,307
Last modified:March 7, 2006 - v1
Checksum:i3EE984572780623B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105426 mRNA. Translation: AAI05427.1.
RefSeqiNP_001039722.1. NM_001046257.2.
UniGeneiBt.17865.

Genome annotation databases

GeneIDi521834.
KEGGibta:521834.

Similar proteinsi

Entry informationi

Entry nameiNOSTN_BOVIN
AccessioniPrimary (citable) accession number: Q2KJB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome