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Q2KJB5 (NOSTN_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nostrin
Alternative name(s):
Nitric oxide synthase trafficker
eNOS trafficking inducer
Gene names
Name:NOSTRIN
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane By similarity.

Subunit structure

Homotrimer. Interacts with DAB2. Interacts with NOS3, DNM2, WASL and CAV1 By similarity.

Subcellular location

Cell membrane By similarity. Cytoplasmic vesicle. Cytoplasm Ref.2.

Tissue specificity

Present in pulmonary arterial endothelial cells (at protein level). Ref.2

Domain

The SH3 domain mediates interaction with NOS3, DNM2 and WASL By similarity.

The FCH domain is necessary for membrane targeting By similarity.

Sequence similarities

Contains 1 FCH domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCell membrane
Cytoplasm
Cytoplasmic vesicle
Membrane
   DomainCoiled coil
SH3 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Nostrin
PRO_0000289088

Regions

Domain1 – 6666FCH
Domain437 – 49660SH3
Coiled coil101 – 12828 Potential
Coiled coil160 – 22263 Potential
Coiled coil295 – 33238 Potential

Amino acid modifications

Modified residue4781Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KJB5 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 3EE984572780623B

FASTA50557,307
        10         20         30         40         50         60 
MRDPLTDCSY NKVYKNLKEF SQNGEDFCKQ ITSILQQRAN LEINYAKGLQ KLATKLSKTL 

        70         80         90        100        110        120 
QSAKKNCLVS AWAWVSEGMK SAGDLHQKLG KAIELEAIKP AHQVLSAHEK KRKSLENEVE 

       130        140        150        160        170        180 
KTANLVISNW NQQIKAKKKL MVSTKKHEAL FHLVESSKQI TTEKEKQKLL NKLKKSTEKL 

       190        200        210        220        230        240 
SKEDENYYQK NVASCSTRLK WENTLENCFQ SILELEKERI QLLCNNLNQY SQHISVFGQT 

       250        260        270        280        290        300 
LTTCHTQIHC AISKIDIEKD IQALMEETTV SSTENKSEFL LTDYFEEDPK NAMSKERQTS 

       310        320        330        340        350        360 
SIKSKLLRLQ KDIEKASRDQ EGLERMLRAY SSHSSFSDSE SKKSTAALMD ENSLKLDLLQ 

       370        380        390        400        410        420 
ANSYKLSSVL AELEQRPQPN HPCSNSIFKW KEKQTHSSVK ISRPVLMKRL ENVVNRASSD 

       430        440        450        460        470        480 
GQRIPSPSST ASGVTQLGNG LCKALYPFQA RQDDELDLEK GDIVTIHKKK DEGWWFGSLK 

       490        500 
GKKGHFPAAY VEELPLNAGD TASQA 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.
[2]"Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging."
Mukhopadhyay S., Xu F., Sehgal P.B.
Am. J. Physiol. 292:H1373-H1389(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC105426 mRNA. Translation: AAI05427.1.
RefSeqNP_001039722.1. NM_001046257.2.
UniGeneBt.17865.

3D structure databases

ProteinModelPortalQ2KJB5.
SMRQ2KJB5. Positions 441-505.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000013682.

Proteomic databases

PRIDEQ2KJB5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID521834.
KEGGbta:521834.

Organism-specific databases

CTD115677.

Phylogenomic databases

eggNOGNOG266189.
HOGENOMHOG000113830.
HOVERGENHBG101730.
InParanoidQ2KJB5.

Family and domain databases

InterProIPR001060. FCH_dom.
IPR011072. HR1_rho-bd.
IPR028535. Nostrin.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR14167:SF22. PTHR14167:SF22. 1 hit.
PfamPF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF46585. SSF46585. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20873379.

Entry information

Entry nameNOSTN_BOVIN
AccessionPrimary (citable) accession number: Q2KJB5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families