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Q2KJB5

- NOSTN_BOVIN

UniProt

Q2KJB5 - NOSTN_BOVIN

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Protein

Nostrin

Gene
NOSTRIN
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane By similarity.

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
  2. regulation of nitric-oxide synthase activity Source: InterPro
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Nostrin
Alternative name(s):
Nitric oxide synthase trafficker
eNOS trafficking inducer
Gene namesi
Name:NOSTRIN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cell membrane By similarity. Cytoplasmic vesicle. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505NostrinPRO_0000289088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei478 – 4781Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2KJB5.

Expressioni

Tissue specificityi

Present in pulmonary arterial endothelial cells (at protein level).1 Publication

Interactioni

Subunit structurei

Homotrimer. Interacts with DAB2. Interacts with NOS3, DNM2, WASL and CAV1 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013682.

Structurei

3D structure databases

ProteinModelPortaliQ2KJB5.
SMRiQ2KJB5. Positions 441-505.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6666FCHAdd
BLAST
Domaini437 – 49660SH3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili101 – 12828 Reviewed predictionAdd
BLAST
Coiled coili160 – 22263 Reviewed predictionAdd
BLAST
Coiled coili295 – 33238 Reviewed predictionAdd
BLAST

Domaini

The SH3 domain mediates interaction with NOS3, DNM2 and WASL By similarity.
The FCH domain is necessary for membrane targeting By similarity.

Sequence similaritiesi

Contains 1 FCH domain.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG266189.
HOGENOMiHOG000113830.
HOVERGENiHBG101730.
InParanoidiQ2KJB5.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR011072. HR1_rho-bd.
IPR028535. Nostrin.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14167:SF22. PTHR14167:SF22. 1 hit.
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF46585. SSF46585. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJB5-1 [UniParc]FASTAAdd to Basket

« Hide

MRDPLTDCSY NKVYKNLKEF SQNGEDFCKQ ITSILQQRAN LEINYAKGLQ    50
KLATKLSKTL QSAKKNCLVS AWAWVSEGMK SAGDLHQKLG KAIELEAIKP 100
AHQVLSAHEK KRKSLENEVE KTANLVISNW NQQIKAKKKL MVSTKKHEAL 150
FHLVESSKQI TTEKEKQKLL NKLKKSTEKL SKEDENYYQK NVASCSTRLK 200
WENTLENCFQ SILELEKERI QLLCNNLNQY SQHISVFGQT LTTCHTQIHC 250
AISKIDIEKD IQALMEETTV SSTENKSEFL LTDYFEEDPK NAMSKERQTS 300
SIKSKLLRLQ KDIEKASRDQ EGLERMLRAY SSHSSFSDSE SKKSTAALMD 350
ENSLKLDLLQ ANSYKLSSVL AELEQRPQPN HPCSNSIFKW KEKQTHSSVK 400
ISRPVLMKRL ENVVNRASSD GQRIPSPSST ASGVTQLGNG LCKALYPFQA 450
RQDDELDLEK GDIVTIHKKK DEGWWFGSLK GKKGHFPAAY VEELPLNAGD 500
TASQA 505
Length:505
Mass (Da):57,307
Last modified:March 7, 2006 - v1
Checksum:i3EE984572780623B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105426 mRNA. Translation: AAI05427.1.
RefSeqiNP_001039722.1. NM_001046257.2.
UniGeneiBt.17865.

Genome annotation databases

GeneIDi521834.
KEGGibta:521834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105426 mRNA. Translation: AAI05427.1 .
RefSeqi NP_001039722.1. NM_001046257.2.
UniGenei Bt.17865.

3D structure databases

ProteinModelPortali Q2KJB5.
SMRi Q2KJB5. Positions 441-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000013682.

Proteomic databases

PRIDEi Q2KJB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 521834.
KEGGi bta:521834.

Organism-specific databases

CTDi 115677.

Phylogenomic databases

eggNOGi NOG266189.
HOGENOMi HOG000113830.
HOVERGENi HBG101730.
InParanoidi Q2KJB5.

Miscellaneous databases

NextBioi 20873379.

Family and domain databases

InterProi IPR001060. FCH_dom.
IPR011072. HR1_rho-bd.
IPR028535. Nostrin.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR14167:SF22. PTHR14167:SF22. 1 hit.
Pfami PF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF46585. SSF46585. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.
  2. "Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging."
    Mukhopadhyay S., Xu F., Sehgal P.B.
    Am. J. Physiol. 292:H1373-H1389(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNOSTN_BOVIN
AccessioniPrimary (citable) accession number: Q2KJB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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