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Q2KJB5

- NOSTN_BOVIN

UniProt

Q2KJB5 - NOSTN_BOVIN

Protein

Nostrin

Gene

NOSTRIN

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.By similarity

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. regulation of nitric-oxide synthase activity Source: InterPro
    3. signal transduction Source: InterPro

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nostrin
    Alternative name(s):
    Nitric oxide synthase trafficker
    eNOS trafficking inducer
    Gene namesi
    Name:NOSTRIN
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cell membrane By similarity. Cytoplasmic vesicle 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505NostrinPRO_0000289088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei478 – 4781PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2KJB5.

    Expressioni

    Tissue specificityi

    Present in pulmonary arterial endothelial cells (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with DAB2. Interacts with NOS3, DNM2, WASL and CAV1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000013682.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJB5.
    SMRiQ2KJB5. Positions 441-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6666FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini437 – 49660SH3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili101 – 12828Sequence AnalysisAdd
    BLAST
    Coiled coili160 – 22263Sequence AnalysisAdd
    BLAST
    Coiled coili295 – 33238Sequence AnalysisAdd
    BLAST

    Domaini

    The SH3 domain mediates interaction with NOS3, DNM2 and WASL.By similarity
    The FCH domain is necessary for membrane targeting.By similarity

    Sequence similaritiesi

    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG266189.
    HOGENOMiHOG000113830.
    HOVERGENiHBG101730.
    InParanoidiQ2KJB5.

    Family and domain databases

    InterProiIPR001060. FCH_dom.
    IPR011072. HR1_rho-bd.
    IPR028535. Nostrin.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR14167:SF22. PTHR14167:SF22. 1 hit.
    PfamiPF00611. FCH. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46585. SSF46585. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KJB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDPLTDCSY NKVYKNLKEF SQNGEDFCKQ ITSILQQRAN LEINYAKGLQ    50
    KLATKLSKTL QSAKKNCLVS AWAWVSEGMK SAGDLHQKLG KAIELEAIKP 100
    AHQVLSAHEK KRKSLENEVE KTANLVISNW NQQIKAKKKL MVSTKKHEAL 150
    FHLVESSKQI TTEKEKQKLL NKLKKSTEKL SKEDENYYQK NVASCSTRLK 200
    WENTLENCFQ SILELEKERI QLLCNNLNQY SQHISVFGQT LTTCHTQIHC 250
    AISKIDIEKD IQALMEETTV SSTENKSEFL LTDYFEEDPK NAMSKERQTS 300
    SIKSKLLRLQ KDIEKASRDQ EGLERMLRAY SSHSSFSDSE SKKSTAALMD 350
    ENSLKLDLLQ ANSYKLSSVL AELEQRPQPN HPCSNSIFKW KEKQTHSSVK 400
    ISRPVLMKRL ENVVNRASSD GQRIPSPSST ASGVTQLGNG LCKALYPFQA 450
    RQDDELDLEK GDIVTIHKKK DEGWWFGSLK GKKGHFPAAY VEELPLNAGD 500
    TASQA 505
    Length:505
    Mass (Da):57,307
    Last modified:March 7, 2006 - v1
    Checksum:i3EE984572780623B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105426 mRNA. Translation: AAI05427.1.
    RefSeqiNP_001039722.1. NM_001046257.2.
    UniGeneiBt.17865.

    Genome annotation databases

    GeneIDi521834.
    KEGGibta:521834.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105426 mRNA. Translation: AAI05427.1 .
    RefSeqi NP_001039722.1. NM_001046257.2.
    UniGenei Bt.17865.

    3D structure databases

    ProteinModelPortali Q2KJB5.
    SMRi Q2KJB5. Positions 441-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000013682.

    Proteomic databases

    PRIDEi Q2KJB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 521834.
    KEGGi bta:521834.

    Organism-specific databases

    CTDi 115677.

    Phylogenomic databases

    eggNOGi NOG266189.
    HOGENOMi HOG000113830.
    HOVERGENi HBG101730.
    InParanoidi Q2KJB5.

    Miscellaneous databases

    NextBioi 20873379.

    Family and domain databases

    InterProi IPR001060. FCH_dom.
    IPR011072. HR1_rho-bd.
    IPR028535. Nostrin.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR14167:SF22. PTHR14167:SF22. 1 hit.
    Pfami PF00611. FCH. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46585. SSF46585. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal liver.
    2. "Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging."
      Mukhopadhyay S., Xu F., Sehgal P.B.
      Am. J. Physiol. 292:H1373-H1389(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNOSTN_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3