Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endophilin-A2

Gene

SH3GL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-A2
Alternative name(s):
Endophilin-2
SH3 domain protein 2B
SH3 domain-containing GRB2-like protein 1
Gene namesi
Name:SH3GL1Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

  • Cytoplasm By similarity
  • Early endosome membrane By similarity; Peripheral membrane protein By similarity
  • Cell projectionpodosome By similarity

  • Note: Associated with postsynaptic endosomes in hippocampal neurons.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094851 – 368Endophilin-A2Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei288PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei298PhosphothreonineBy similarity1
Modified residuei315PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KJA1.
PRIDEiQ2KJA1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006007.

Interactioni

Subunit structurei

Interacts with ARC, SYNJ1 and DNM1. Interacts with PDCD6IP. Interacts with BIN2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007890.

Structurei

3D structure databases

ProteinModelPortaliQ2KJA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 249BARPROSITE-ProRule annotationAdd BLAST232
Domaini306 – 365SH3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 21Membrane-binding amphipathic helixBy similarityAdd BLAST21
Regioni60 – 87Required for dimerization upon membrane associationBy similarityAdd BLAST28
Regioni218 – 254Interaction with ARCBy similarityAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 250Sequence analysisAdd BLAST70

Domaini

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.By similarity

Sequence similaritiesi

Belongs to the endophilin family.Sequence analysis
Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG1118. Eukaryota.
ENOG410XNYB. LUCA.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000231641.
HOVERGENiHBG052866.
InParanoidiQ2KJA1.
KOiK11247.
OMAiDPLQGLC.
OrthoDBiEOG091G16FW.
TreeFamiTF313281.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV
60 70 80 90 100
LARTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH
110 120 130 140 150
GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCDKD
160 170 180 190 200
LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQAMEKF EESKEVAETS
210 220 230 240 250
MHHLLETDIE QVSQLSALVD AQLDYHRQAV QILDELADKL KRRMREASSR
260 270 280 290 300
PKREYKPKPR ELLDLGEPEQ SNGGFPCAAA PKITASSSFR SSDKPVRTPS
310 320 330 340 350
RSMPPLDQPS CKALYDFEPE NDGELGFHEG DIITLTNQID ENWYEGMLDG
360
QSGFFPLSYV EVLVPLPQ
Length:368
Mass (Da):41,455
Last modified:March 7, 2006 - v1
Checksum:i58FD0A362875628F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285A → AA in ABF57308 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025352 mRNA. Translation: ABF57308.1.
BC105444 mRNA. Translation: AAI05445.1.
RefSeqiNP_001039595.1. NM_001046130.2.
XP_005208990.1. XM_005208933.2.
UniGeneiBt.37802.

Genome annotation databases

EnsembliENSBTAT00000007890; ENSBTAP00000007890; ENSBTAG00000006007.
GeneIDi512719.
KEGGibta:512719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025352 mRNA. Translation: ABF57308.1.
BC105444 mRNA. Translation: AAI05445.1.
RefSeqiNP_001039595.1. NM_001046130.2.
XP_005208990.1. XM_005208933.2.
UniGeneiBt.37802.

3D structure databases

ProteinModelPortaliQ2KJA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007890.

Proteomic databases

PaxDbiQ2KJA1.
PRIDEiQ2KJA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007890; ENSBTAP00000007890; ENSBTAG00000006007.
GeneIDi512719.
KEGGibta:512719.

Organism-specific databases

CTDi6455.

Phylogenomic databases

eggNOGiKOG1118. Eukaryota.
ENOG410XNYB. LUCA.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000231641.
HOVERGENiHBG052866.
InParanoidiQ2KJA1.
KOiK11247.
OMAiDPLQGLC.
OrthoDBiEOG091G16FW.
TreeFamiTF313281.

Gene expression databases

BgeeiENSBTAG00000006007.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSH3G1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJA1
Secondary accession number(s): Q1JPK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.