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Protein

Transmembrane emp24 domain-containing protein 5

Gene

TMED5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-3238698. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 5
Alternative name(s):
p24 family protein gamma 2
Short name:
p24gamma2
Gene namesi
Name:TMED5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 193LumenalSequence analysisAdd BLAST169
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 226CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000024034725 – 226Transmembrane emp24 domain-containing protein 5Add BLAST202

Proteomic databases

PaxDbiQ2KJ84.
PRIDEiQ2KJ84.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020180.

Interactioni

Subunit structurei

Interacts with TMED9 and TMED10.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032097.

Structurei

3D structure databases

SMRiQ2KJ84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 123GOLDPROSITE-ProRule annotationAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi217 – 218Mediates export from ERSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
GeneTreeiENSGT00670000097656.
HOGENOMiHOG000039809.
HOVERGENiHBG000271.
InParanoidiQ2KJ84.
KOiK14825.
OMAiYDMKVQD.
OrthoDBiEOG091G0RNG.
TreeFamiTF313000.

Family and domain databases

InterProiView protein in InterPro
IPR009038. GOLD_dom.
IPR036598. GOLD_dom_sf.
IPR015717. TMED5.
IPR015720. TMP21-related.
PANTHERiPTHR22811. PTHR22811. 1 hit.
PTHR22811:SF41. PTHR22811:SF41. 1 hit.
PfamiView protein in Pfam
PF01105. EMP24_GP25L. 1 hit.
SMARTiView protein in SMART
SM01190. EMP24_GP25L. 1 hit.
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiView protein in PROSITE
PS50866. GOLD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJ84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKTWLPFP VVLLAALLLP RAAGFTPSLD SDFTFTLPAG QKECFYQPMP
60 70 80 90 100
LKASLEIEYQ VLDGAGLDID FHLASPEGKT LVFEQRKSDG VHTIETEVGD
110 120 130 140 150
YMFCFDNTFS TISEKVIFFE LILDNMGEQE QEQEDWKKYI TGTDMLDMKL
160 170 180 190 200
EDILESINSI KSRLSKSGHI QTLLRAFEAR DRNIQESNFD RVNFWSMVNL
210 220
VVMVVVSAIQ VYMLKSLFED KRKSRT
Length:226
Mass (Da):25,875
Last modified:March 7, 2006 - v1
Checksum:i36E306A97489647E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030528 mRNA. Translation: ABQ12968.1.
BC105474 mRNA. Translation: AAI05475.1.
RefSeqiNP_001039842.1. NM_001046377.1.
UniGeneiBt.27858.

Genome annotation databases

EnsembliENSBTAT00000032159; ENSBTAP00000032097; ENSBTAG00000020180.
GeneIDi534351.
KEGGibta:534351.

Similar proteinsi

Entry informationi

Entry nameiTMED5_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ84
Secondary accession number(s): A5D9A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families