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Q2KJ72

- UBP21_BOVIN

UniProt

Q2KJ72 - UBP21_BOVIN

Protein

Ubiquitin carboxyl-terminal hydrolase 21

Gene

USP21

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei221 – 2211NucleophilePROSITE-ProRule annotation
    Metal bindingi384 – 3841ZincBy similarity
    Metal bindingi387 – 3871ZincBy similarity
    Metal bindingi437 – 4371ZincBy similarity
    Metal bindingi440 – 4401ZincBy similarity
    Active sitei518 – 5181Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. NEDD8-specific protease activity Source: UniProtKB
    4. transcription coactivator activity Source: UniProtKB
    5. ubiquitin-specific protease activity Source: UniProtKB
    6. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. histone deubiquitination Source: UniProtKB
    2. positive regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC19.034.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 21
    Ubiquitin thioesterase 21
    Ubiquitin-specific-processing protease 21
    Gene namesi
    Name:USP21
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Ubiquitin carboxyl-terminal hydrolase 21PRO_0000367508Add
    BLAST

    Proteomic databases

    PRIDEiQ2KJ72.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000029184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJ72.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini212 – 558347USPAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi134 – 15219Nuclear export signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP21 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000231498.
    HOVERGENiHBG011164.
    InParanoidiQ2KJ72.
    KOiK11833.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KJ72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQASEHRLG RTREPPLNIQ PRVGSKLPFA PRARSKERRN PAPGPNPMLR    50
    PLPPRPGPPE ERLKKLELGR GRTSGPRPSG PLRADHGVPL PGSPPPTVAL 100
    PLPSRTNLAR SKSVSSGDLR PMGIALGGHR GTGELGAALS RLALRPEPPP 150
    LRRSTSLRRL GGFPGPPTLF SIRTEPPTPH GSFHVISARP SEPFYSDDKM 200
    AHHTLLLGSG HVGLRNLGNT CFLNALLQCL SSTRPLRDFC LRRDFRQEVP 250
    GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 300
    DAQEFLKLLM ERLHLEINRR GRRAPPILAS SPAPHPPRLG GALLEEPELS 350
    DDDRANLMWK RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL 400
    SLPIPKKGFA GGKVSLRDCF NLFTKEEELE SENAPVCDRC RQKTRSTKKL 450
    TVQRFPRILV LHLNRFSASR GSIKKSSVGV DFPLQRLSLG DFASDKAGSP 500
    VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV SENQVASSEG 550
    YVLFYQLMQE PPRCL 565
    Length:565
    Mass (Da):62,619
    Last modified:March 7, 2006 - v1
    Checksum:i6AA35C030406094C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105488 mRNA. Translation: AAI05489.1.
    RefSeqiNP_001039841.1. NM_001046376.2.
    UniGeneiBt.24990.

    Genome annotation databases

    GeneIDi534273.
    KEGGibta:534273.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105488 mRNA. Translation: AAI05489.1 .
    RefSeqi NP_001039841.1. NM_001046376.2.
    UniGenei Bt.24990.

    3D structure databases

    ProteinModelPortali Q2KJ72.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000029184.

    Protein family/group databases

    MEROPSi C19.034.

    Proteomic databases

    PRIDEi Q2KJ72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 534273.
    KEGGi bta:534273.

    Organism-specific databases

    CTDi 27005.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000231498.
    HOVERGENi HBG011164.
    InParanoidi Q2KJ72.
    KOi K11833.

    Miscellaneous databases

    NextBioi 20876334.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiUBP21_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJ72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3