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Q2KJ72

- UBP21_BOVIN

UniProt

Q2KJ72 - UBP21_BOVIN

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Protein
Ubiquitin carboxyl-terminal hydrolase 21
Gene
USP21
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei221 – 2211Nucleophile By similarity
Metal bindingi384 – 3841Zinc By similarity
Metal bindingi387 – 3871Zinc By similarity
Metal bindingi437 – 4371Zinc By similarity
Metal bindingi440 – 4401Zinc By similarity
Active sitei518 – 5181Proton acceptor By similarity

GO - Molecular functioni

  1. NEDD8-specific protease activity Source: UniProtKB
  2. cysteine-type peptidase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. transcription coactivator activity Source: UniProtKB
  5. ubiquitin thiolesterase activity Source: UniProtKB
  6. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. histone deubiquitination Source: UniProtKB
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.034.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 21
Ubiquitin thioesterase 21
Ubiquitin-specific-processing protease 21
Gene namesi
Name:USP21
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Ubiquitin carboxyl-terminal hydrolase 21
PRO_0000367508Add
BLAST

Proteomic databases

PRIDEiQ2KJ72.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029184.

Structurei

3D structure databases

ProteinModelPortaliQ2KJ72.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 558347USP
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 15219Nuclear export signal By similarity
Add
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000231498.
HOVERGENiHBG011164.
InParanoidiQ2KJ72.
KOiK11833.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJ72-1 [UniParc]FASTAAdd to Basket

« Hide

MPQASEHRLG RTREPPLNIQ PRVGSKLPFA PRARSKERRN PAPGPNPMLR    50
PLPPRPGPPE ERLKKLELGR GRTSGPRPSG PLRADHGVPL PGSPPPTVAL 100
PLPSRTNLAR SKSVSSGDLR PMGIALGGHR GTGELGAALS RLALRPEPPP 150
LRRSTSLRRL GGFPGPPTLF SIRTEPPTPH GSFHVISARP SEPFYSDDKM 200
AHHTLLLGSG HVGLRNLGNT CFLNALLQCL SSTRPLRDFC LRRDFRQEVP 250
GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 300
DAQEFLKLLM ERLHLEINRR GRRAPPILAS SPAPHPPRLG GALLEEPELS 350
DDDRANLMWK RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL 400
SLPIPKKGFA GGKVSLRDCF NLFTKEEELE SENAPVCDRC RQKTRSTKKL 450
TVQRFPRILV LHLNRFSASR GSIKKSSVGV DFPLQRLSLG DFASDKAGSP 500
VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV SENQVASSEG 550
YVLFYQLMQE PPRCL 565
Length:565
Mass (Da):62,619
Last modified:March 7, 2006 - v1
Checksum:i6AA35C030406094C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105488 mRNA. Translation: AAI05489.1.
RefSeqiNP_001039841.1. NM_001046376.2.
UniGeneiBt.24990.

Genome annotation databases

GeneIDi534273.
KEGGibta:534273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105488 mRNA. Translation: AAI05489.1 .
RefSeqi NP_001039841.1. NM_001046376.2.
UniGenei Bt.24990.

3D structure databases

ProteinModelPortali Q2KJ72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000029184.

Protein family/group databases

MEROPSi C19.034.

Proteomic databases

PRIDEi Q2KJ72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 534273.
KEGGi bta:534273.

Organism-specific databases

CTDi 27005.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000231498.
HOVERGENi HBG011164.
InParanoidi Q2KJ72.
KOi K11833.

Miscellaneous databases

NextBioi 20876334.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiUBP21_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 7, 2006
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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