ID   ARGI1_BOVIN             Reviewed;         322 AA.
AC   Q2KJ64;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Arginase-1;
DE            EC=3.5.3.1;
DE   AltName: Full=Type I arginase;
DE   AltName: Full=Liver-type arginase;
GN   Name=ARG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-arginine + H(2)O = L-ornithine + urea.
CC   -!- COFACTOR: Binds 2 manganese ions per subunit (By similarity).
CC   -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea
CC       from L-arginine: step 1/1.
CC   -!- SUBUNIT: Homotrimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the arginase family.
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DR   EMBL; BC105497; AAI05498.1; -; mRNA.
DR   IPI; IPI00696673; -.
DR   RefSeq; NP_001039619.1; -.
DR   UniGene; Bt.97117; -.
DR   SMR; Q2KJ64; 6-318.
DR   Ensembl; ENSBTAG00000012403; Bos taurus.
DR   GeneID; 513608; -.
DR   KEGG; bta:513608; -.
DR   HOVERGEN; Q2KJ64; -.
DR   OMA; Q2KJ64; QIVKNPR.
DR   BRENDA; 3.5.3.1; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004053; F:arginase activity; IEA:EC.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000050; P:urea cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR005924; Arginase.
DR   InterPro; IPR014033; Arginase_sub.
DR   InterPro; IPR006035; Ureohydrolase.
DR   Gene3D; G3DSA:3.40.800.10; Ureohydrolase; 1.
DR   PANTHER; PTHR11358:SF2; Arginase_sub; 1.
DR   PANTHER; PTHR11358; Ureohydrolase; 1.
DR   Pfam; PF00491; Arginase; 1.
DR   PRINTS; PR00116; ARGINASE.
DR   TIGRFAMs; TIGR01229; rocF_arginase; 1.
DR   PROSITE; PS01053; ARGINASE_1; 1.
DR   PROSITE; PS51409; ARGINASE_2; 1.
PE   2: Evidence at transcript level;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Manganese; Metal-binding;
KW   Phosphoprotein; Urea cycle.
FT   CHAIN         1    322       Arginase-1.
FT                                /FTId=PRO_0000240339.
FT   REGION      126    130       Substrate binding (By similarity).
FT   REGION      137    139       Substrate binding (By similarity).
FT   METAL       101    101       Manganese 1 (By similarity).
FT   METAL       124    124       Manganese 1 (By similarity).
FT   METAL       124    124       Manganese 2 (By similarity).
FT   METAL       126    126       Manganese 2 (By similarity).
FT   METAL       128    128       Manganese 1 (By similarity).
FT   METAL       232    232       Manganese 1 (By similarity).
FT   METAL       232    232       Manganese 2 (By similarity).
FT   METAL       234    234       Manganese 2 (By similarity).
FT   BINDING     183    183       Substrate (By similarity).
FT   MOD_RES       3      3       Phosphoserine (By similarity).
FT   MOD_RES     230    230       Phosphoserine (By similarity).
SQ   SEQUENCE   322 AA;  35009 MW;  B71BE758F1AB83CA CRC64;
     MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY GDLSFADNLD
     DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD HSLAIGSISG HARVHPDLCV
     IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR
     DVDPGEHYIL KTLGIKYFSM TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF
     TPATGTPVQG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT
     MACFGVAREG NHKPIDYLSP PK
//