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Q2KJ64

- ARGI1_BOVIN

UniProt

Q2KJ64 - ARGI1_BOVIN

Protein

Arginase-1

Gene

ARG1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.

    Cofactori

    Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Manganese 1PROSITE-ProRule annotation
    Metal bindingi124 – 1241Manganese 1PROSITE-ProRule annotation
    Metal bindingi124 – 1241Manganese 2PROSITE-ProRule annotation
    Metal bindingi126 – 1261Manganese 2PROSITE-ProRule annotation
    Metal bindingi128 – 1281Manganese 1PROSITE-ProRule annotation
    Binding sitei183 – 1831SubstrateBy similarity
    Metal bindingi232 – 2321Manganese 1PROSITE-ProRule annotation
    Metal bindingi232 – 2321Manganese 2PROSITE-ProRule annotation
    Metal bindingi234 – 2341Manganese 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. arginase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine metabolic process Source: UniProtKB-KW
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism, Urea cycle

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_208559. Urea cycle.
    SABIO-RKQ2KJ64.
    UniPathwayiUPA00158; UER00270.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginase-1 (EC:3.5.3.1)
    Alternative name(s):
    Liver-type arginase
    Type I arginase
    Gene namesi
    Name:ARG1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 9

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Arginase-1PRO_0000240339Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71PhosphoserineBy similarity
    Modified residuei17 – 171N6-succinyllysineBy similarity
    Modified residuei75 – 751N6-succinyllysineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ2KJ64.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000016461.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJ64.
    SMRiQ2KJ64. Positions 6-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni126 – 1305Substrate bindingBy similarity
    Regioni137 – 1393Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the arginase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0010.
    GeneTreeiENSGT00530000063082.
    HOGENOMiHOG000204319.
    HOVERGENiHBG003030.
    InParanoidiQ2KJ64.
    KOiK01476.
    OMAiKEQECDV.
    OrthoDBiEOG747PJ5.
    TreeFamiTF300034.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KJ64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY    50
    GDLSFADNLD DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD 100
    HSLAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK 150
    ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM 200
    TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVQG 250
    GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT 300
    MACFGVAREG NHKPIDYLSP PK 322
    Length:322
    Mass (Da):35,009
    Last modified:March 7, 2006 - v1
    Checksum:iB71BE758F1AB83CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105497 mRNA. Translation: AAI05498.1.
    RefSeqiNP_001039619.1. NM_001046154.1.
    XP_005210981.1. XM_005210924.1.
    UniGeneiBt.97117.

    Genome annotation databases

    EnsembliENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403.
    GeneIDi513608.
    KEGGibta:513608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105497 mRNA. Translation: AAI05498.1 .
    RefSeqi NP_001039619.1. NM_001046154.1.
    XP_005210981.1. XM_005210924.1.
    UniGenei Bt.97117.

    3D structure databases

    ProteinModelPortali Q2KJ64.
    SMRi Q2KJ64. Positions 6-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000016461.

    Chemistry

    ChEMBLi CHEMBL1075060.

    Proteomic databases

    PaxDbi Q2KJ64.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000016461 ; ENSBTAP00000016461 ; ENSBTAG00000012403 .
    GeneIDi 513608.
    KEGGi bta:513608.

    Organism-specific databases

    CTDi 383.

    Phylogenomic databases

    eggNOGi COG0010.
    GeneTreei ENSGT00530000063082.
    HOGENOMi HOG000204319.
    HOVERGENi HBG003030.
    InParanoidi Q2KJ64.
    KOi K01476.
    OMAi KEQECDV.
    OrthoDBi EOG747PJ5.
    TreeFami TF300034.

    Enzyme and pathway databases

    UniPathwayi UPA00158 ; UER00270 .
    Reactomei REACT_208559. Urea cycle.
    SABIO-RK Q2KJ64.

    Miscellaneous databases

    NextBioi 20870945.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal liver.

    Entry informationi

    Entry nameiARGI1_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJ64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3