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Protein

Arginase-1

Gene

ARG1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Manganese 1PROSITE-ProRule annotation
Metal bindingi124 – 1241Manganese 1PROSITE-ProRule annotation
Metal bindingi124 – 1241Manganese 2PROSITE-ProRule annotation
Metal bindingi126 – 1261Manganese 2PROSITE-ProRule annotation
Metal bindingi128 – 1281Manganese 1PROSITE-ProRule annotation
Binding sitei183 – 1831SubstrateBy similarity
Metal bindingi232 – 2321Manganese 1PROSITE-ProRule annotation
Metal bindingi232 – 2321Manganese 2PROSITE-ProRule annotation
Metal bindingi234 – 2341Manganese 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. arginase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine metabolic process Source: UniProtKB-KW
  2. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism, Urea cycle

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_276853. Urea cycle.
SABIO-RKQ2KJ64.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase-1 (EC:3.5.3.1)
Alternative name(s):
Liver-type arginase
Type I arginase
Gene namesi
Name:ARG1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 9

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Arginase-1PRO_0000240339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei17 – 171N6-succinyllysineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei75 – 751N6-succinyllysineBy similarity
Modified residuei217 – 2171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KJ64.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016461.

Structurei

3D structure databases

ProteinModelPortaliQ2KJ64.
SMRiQ2KJ64. Positions 6-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1305Substrate bindingBy similarity
Regioni137 – 1393Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0010.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204319.
HOVERGENiHBG003030.
InParanoidiQ2KJ64.
KOiK01476.
OMAiDYGDLPF.
OrthoDBiEOG747PJ5.
TreeFamiTF300034.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY
60 70 80 90 100
GDLSFADNLD DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD
110 120 130 140 150
HSLAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK
160 170 180 190 200
ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM
210 220 230 240 250
TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVQG
260 270 280 290 300
GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT
310 320
MACFGVAREG NHKPIDYLSP PK
Length:322
Mass (Da):35,009
Last modified:March 7, 2006 - v1
Checksum:iB71BE758F1AB83CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105497 mRNA. Translation: AAI05498.1.
RefSeqiNP_001039619.1. NM_001046154.1.
XP_005210981.1. XM_005210924.2.
XP_010806852.1. XM_010808550.1.
UniGeneiBt.97117.

Genome annotation databases

EnsembliENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403.
GeneIDi513608.
KEGGibta:513608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105497 mRNA. Translation: AAI05498.1.
RefSeqiNP_001039619.1. NM_001046154.1.
XP_005210981.1. XM_005210924.2.
XP_010806852.1. XM_010808550.1.
UniGeneiBt.97117.

3D structure databases

ProteinModelPortaliQ2KJ64.
SMRiQ2KJ64. Positions 6-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016461.

Chemistry

BindingDBiQ2KJ64.
ChEMBLiCHEMBL1075060.

Proteomic databases

PaxDbiQ2KJ64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403.
GeneIDi513608.
KEGGibta:513608.

Organism-specific databases

CTDi383.

Phylogenomic databases

eggNOGiCOG0010.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204319.
HOVERGENiHBG003030.
InParanoidiQ2KJ64.
KOiK01476.
OMAiDYGDLPF.
OrthoDBiEOG747PJ5.
TreeFamiTF300034.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.
ReactomeiREACT_276853. Urea cycle.
SABIO-RKQ2KJ64.

Miscellaneous databases

NextBioi20870945.
PROiQ2KJ64.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiARGI1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: April 29, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.