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Reviewed, UniProtKB/Swiss-Prot Q2KJ64 (ARGI1_BOVIN)

Last modified June 16, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Arginase-1
    EC=3.5.3.1
Alternative name(s):
    Type I arginase
    Liver-type arginase
Gene names
Name: ARG1
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

L-arginine + H2O = L-ornithine + urea.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Pathway

Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.

Subunit structure

Homotrimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the arginase family.

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Ontologies

Keywords
   Biological processArginine metabolism
Urea cycle
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionHydrolase
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

urea cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionarginase activity

Inferred from electronic annotation. Source: EC

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Arginase-1
PRO_0000240339

Regions

Region126 – 1305Substrate binding By similarity
Region137 – 1393Substrate binding By similarity

Sites

Metal binding1011Manganese 1 By similarity
Metal binding1241Manganese 1 By similarity
Metal binding1241Manganese 2 By similarity
Metal binding1261Manganese 2 By similarity
Metal binding1281Manganese 1 By similarity
Metal binding2321Manganese 1 By similarity
Metal binding2321Manganese 2 By similarity
Metal binding2341Manganese 2 By similarity
Binding site1831Substrate By similarity

Amino acid modifications

Modified residue31Phosphoserine By similarity
Modified residue2301Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q2KJ64-1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: B71BE758F1AB83CA

FASTA32235,009
        10         20         30         40         50         60 
MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY GDLSFADNLD 

        70         80         90        100        110        120 
DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD HSLAIGSISG HARVHPDLCV 

       130        140        150        160        170        180 
IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR 

       190        200        210        220        230        240 
DVDPGEHYIL KTLGIKYFSM TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF 

       250        260        270        280        290        300 
TPATGTPVQG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT 

       310        320 
MACFGVAREG NHKPIDYLSP PK

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.

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Cross-references

Sequence databases

BC105497 mRNA. Translation: AAI05498.1.
IPIIPI00696673.
RefSeqNP_001039619.1.
UniGeneBt.97117

3D structure databases

SMRQ2KJ64. Positions 6-318.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000012403. Bos taurus. [Contig view]
GeneID513608.
KEGGbta:513608.

Phylogenomic databases

HOVERGENQ2KJ64.
OMAQ2KJ64. QIVKNPR.

Enzyme and pathway databases

BRENDA3.5.3.1. 251.

Family and domain databases

InterProIPR005924. Arginase.
IPR014033. Arginase_sub.
IPR006035. Ureohydrolase.
[Graphical view]
Gene3DG3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHERPTHR11358:SF2. Arginase_sub. 1 hit.
PTHR11358. Ureohydrolase. 1 hit.
PfamPF00491. Arginase. 1 hit.
[Graphical view]
PRINTSPR00116. ARGINASE.
TIGRFAMsTIGR01229. rocF_arginase. 1 hit.
PROSITEPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameARGI1_BOVIN
AccessionPrimary (citable) accession number: Q2KJ64
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents