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Protein

Arginase-1

Gene

ARG1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (ARG2), Arginase-1 (ARG1), Arginase-2, mitochondrial (ARG2)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 1PROSITE-ProRule annotation1
Metal bindingi124Manganese 2PROSITE-ProRule annotation1
Metal bindingi126Manganese 2PROSITE-ProRule annotation1
Metal bindingi128Manganese 1PROSITE-ProRule annotation1
Binding sitei183SubstrateBy similarity1
Metal bindingi232Manganese 1PROSITE-ProRule annotation1
Metal bindingi232Manganese 2PROSITE-ProRule annotation1
Metal bindingi234Manganese 2PROSITE-ProRule annotation1
Binding sitei246SubstrateBy similarity1
Binding sitei277SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism, Urea cycle

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-6798695. Neutrophil degranulation.
R-BTA-70635. Urea cycle.
SABIO-RKQ2KJ64.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase-1 (EC:3.5.3.1By similarity)
Alternative name(s):
Liver-type arginase
Type I arginase
Gene namesi
Name:ARG1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075060.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002403391 – 322Arginase-1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei17N6-succinyllysineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei75N6-succinyllysineBy similarity1
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KJ64.
PeptideAtlasiQ2KJ64.
PRIDEiQ2KJ64.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012403.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016461.

Chemistry databases

BindingDBiQ2KJ64.

Structurei

3D structure databases

ProteinModelPortaliQ2KJ64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 130Substrate bindingBy similarity5
Regioni137 – 139Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204319.
HOVERGENiHBG003030.
InParanoidiQ2KJ64.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
TreeFamiTF300034.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY
60 70 80 90 100
GDLSFADNLD DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD
110 120 130 140 150
HSLAIGSISG HARVHPDLCV IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK
160 170 180 190 200
ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM
210 220 230 240 250
TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVQG
260 270 280 290 300
GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT
310 320
MACFGVAREG NHKPIDYLSP PK
Length:322
Mass (Da):35,009
Last modified:March 7, 2006 - v1
Checksum:iB71BE758F1AB83CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105497 mRNA. Translation: AAI05498.1.
RefSeqiNP_001039619.1. NM_001046154.1.
XP_005210981.1. XM_005210924.3.
XP_010806852.1. XM_010808550.2.
UniGeneiBt.97117.

Genome annotation databases

EnsembliENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403.
GeneIDi513608.
KEGGibta:513608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105497 mRNA. Translation: AAI05498.1.
RefSeqiNP_001039619.1. NM_001046154.1.
XP_005210981.1. XM_005210924.3.
XP_010806852.1. XM_010808550.2.
UniGeneiBt.97117.

3D structure databases

ProteinModelPortaliQ2KJ64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016461.

Chemistry databases

BindingDBiQ2KJ64.
ChEMBLiCHEMBL1075060.

Proteomic databases

PaxDbiQ2KJ64.
PeptideAtlasiQ2KJ64.
PRIDEiQ2KJ64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403.
GeneIDi513608.
KEGGibta:513608.

Organism-specific databases

CTDi383.

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204319.
HOVERGENiHBG003030.
InParanoidiQ2KJ64.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.
TreeFamiTF300034.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.
ReactomeiR-BTA-6798695. Neutrophil degranulation.
R-BTA-70635. Urea cycle.
SABIO-RKQ2KJ64.

Miscellaneous databases

PROiQ2KJ64.

Gene expression databases

BgeeiENSBTAG00000012403.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGI1_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.