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Q2KJ64 (ARGI1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginase-1

EC=3.5.3.1
Alternative name(s):
Liver-type arginase
Type I arginase
Gene names
Name:ARG1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-arginine + H2O = L-ornithine + urea.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Pathway

Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.

Subunit structure

Homotrimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the arginase family.

Ontologies

Keywords
   Biological processArginine metabolism
Urea cycle
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionHydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

urea cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionarginase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Arginase-1
PRO_0000240339

Regions

Region126 – 1305Substrate binding By similarity
Region137 – 1393Substrate binding By similarity

Sites

Metal binding1011Manganese 1 By similarity
Metal binding1241Manganese 1 By similarity
Metal binding1241Manganese 2 By similarity
Metal binding1261Manganese 2 By similarity
Metal binding1281Manganese 1 By similarity
Metal binding2321Manganese 1 By similarity
Metal binding2321Manganese 2 By similarity
Metal binding2341Manganese 2 By similarity
Binding site1831Substrate By similarity

Amino acid modifications

Modified residue71Phosphoserine By similarity
Modified residue171N6-succinyllysine By similarity
Modified residue751N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KJ64 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: B71BE758F1AB83CA

FASTA32235,009
        10         20         30         40         50         60 
MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY GDLSFADNLD 

        70         80         90        100        110        120 
DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD HSLAIGSISG HARVHPDLCV 

       130        140        150        160        170        180 
IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR 

       190        200        210        220        230        240 
DVDPGEHYIL KTLGIKYFSM TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF 

       250        260        270        280        290        300 
TPATGTPVQG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT 

       310        320 
MACFGVAREG NHKPIDYLSP PK 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC105497 mRNA. Translation: AAI05498.1.
RefSeqNP_001039619.1. NM_001046154.1.
XP_005210981.1. XM_005210924.1.
UniGeneBt.97117.

3D structure databases

ProteinModelPortalQ2KJ64.
SMRQ2KJ64. Positions 6-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000016461.

Chemistry

ChEMBLCHEMBL1075060.

Proteomic databases

PaxDbQ2KJ64.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403.
GeneID513608.
KEGGbta:513608.

Organism-specific databases

CTD383.

Phylogenomic databases

eggNOGCOG0010.
GeneTreeENSGT00530000063082.
HOGENOMHOG000204319.
HOVERGENHBG003030.
InParanoidQ2KJ64.
KOK01476.
OMAKEQECDV.
OrthoDBEOG747PJ5.
TreeFamTF300034.

Enzyme and pathway databases

SABIO-RKQ2KJ64.
UniPathwayUPA00158; UER00270.

Family and domain databases

Gene3D3.40.800.10. 1 hit.
InterProIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERPTHR11358. PTHR11358. 1 hit.
PfamPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFPIRSF036979. Arginase. 1 hit.
PRINTSPR00116. ARGINASE.
TIGRFAMsTIGR01229. rocF_arginase. 1 hit.
PROSITEPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870945.

Entry information

Entry nameARGI1_BOVIN
AccessionPrimary (citable) accession number: Q2KJ64
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways