Reviewed, UniProtKB/Swiss-Prot Q2KJ64 (ARGI1_BOVIN)

Names and origin

Protein names

Recommended name:
    Arginase-1
    EC=3.5.3.1
Alternative name(s):
    Type I arginase
    Liver-type arginase

Gene names

Name:

ARG1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-ornithine + urea.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the arginase family.

Ontologies

Keywords
Biological process	Arginine metabolism Urea cycle
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW urea cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginase activity Inferred from electronic annotation. Source: EC manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Arginase-1		PRO_0000240339
Regions
	Region	126 – 130	5	Substrate binding By similarity
	Region	137 – 139	3	Substrate binding By similarity
Sites
	Metal binding	101	1	Manganese 1 By similarity
	Metal binding	124	1	Manganese 1 By similarity
	Metal binding	124	1	Manganese 2 By similarity
	Metal binding	126	1	Manganese 2 By similarity
	Metal binding	128	1	Manganese 1 By similarity
	Metal binding	232	1	Manganese 1 By similarity
	Metal binding	232	1	Manganese 2 By similarity
	Metal binding	234	1	Manganese 2 By similarity
	Binding site	183	1	Substrate By similarity
Amino acid modifications
	Modified residue	3	1	Phosphoserine By similarity
	Modified residue	230	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KJ64-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: B71BE758F1AB83CA	FASTA	322	35,009
	10 20 30 40 50 60 MSSKPQSIGV IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KELECDVKDY GDLSFADNLD 70 80 90 100 110 120 DSPFQIVKNP RCVGKASEKL ADVVAEVKKT GRISLVLGGD HSLAIGSISG HARVHPDLCV 130 140 150 160 170 180 IWVDAHTDIN TPLTTKTGNL HGQPVSFLLK ELKEKMPEVP GFYWVAPCIS AKDIVYIGLR 190 200 210 220 230 240 DVDPGEHYIL KTLGIKYFSM TEVDKLGIGK VMEETFSYLL GRKKRPIHLS FDVDGLDPSF 250 260 270 280 290 300 TPATGTPVQG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTTVAIT 310 320 MACFGVAREG NHKPIDYLSP PK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105497 mRNA. Translation: AAI05498.1.
IPI	IPI00696673.
RefSeq	NP_001039619.1.
UniGene	Bt.97117
3D structure databases
SMR	Q2KJ64. Positions 6-319.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KJ64.
Genome annotation databases
Ensembl	ENSBTAT00000016461; ENSBTAP00000016461; ENSBTAG00000012403; Bos taurus. [Genome view]
GeneID	513608.
KEGG	bta:513608.
Organism-specific databases
CTD	513608.
Phylogenomic databases
eggNOG	maNOG09430.
HOVERGEN	Q2KJ64.
InParanoid	Q2KJ64.
OMA	ADIPNDS.
PhylomeDB	Q2KJ64.
Enzyme and pathway databases
BRENDA	3.5.3.1. 251.
Family and domain databases
InterPro	IPR005924. Arginase. IPR014033. Arginase_sub. IPR006035. Ureohydrolase. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHER	PTHR11358:SF2. Arginase_sub. 1 hit. PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01229. rocF_arginase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGI1_BOVIN

Accession

Primary (citable) accession number: Q2KJ64

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 7, 2006
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)