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Q2KJ61

- ELP3_BOVIN

UniProt

Q2KJ61 - ELP3_BOVIN

Protein

Elongator complex protein 3

Gene

ELP3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi99 – 991Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi109 – 1091Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi112 – 1121Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. histone acetyltransferase activity Source: UniProtKB-EC
    3. iron-sulfur cluster binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. phosphorylase kinase regulator activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of cell migration Source: UniProtKB
    2. regulation of protein kinase activity Source: GOC
    3. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. transcription elongation from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    ReactomeiREACT_219482. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongator complex protein 3 (EC:2.3.1.48)
    Gene namesi
    Name:ELP3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 8

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. DNA-directed RNA polymerase II, holoenzyme Source: Ensembl
    3. Elongator holoenzyme complex Source: UniProtKB
    4. nucleolus Source: Ensembl
    5. transcription elongation factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Elongator complex protein 3PRO_0000283985Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei202 – 2021PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2KJ61.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. IKBKAP/ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with IKBKAP/ELP1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000003541.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJ61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini396 – 547152N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1243.
    GeneTreeiENSGT00390000013141.
    HOGENOMiHOG000227514.
    HOVERGENiHBG107845.
    InParanoidiQ2KJ61.
    KOiK07739.
    OMAiGYKVVSH.
    OrthoDBiEOG7V765W.
    TreeFamiTF105752.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KJ61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRQKRKGDLS PAQLMMLTIG DVIKQLIEAH EQGKDIDLNK VKTRTAAKYG    50
    LSAQPRLVDI IAAVPPQYRK VLVPKLKAKP IRTASGIAVV AVMCKPHRCP 100
    HISFTGNICV YCPGGPDSDF EYSTQSYTGY EPTSMRAIRA RYDPYLQTRH 150
    RIEQLKQLGH SVDKVEFIVM GGTFMALPEE YRDYFIRNLH DALSGHTSNN 200
    IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC TRLEIGVQSV 250
    YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ 300
    FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLIELVA 350
    RILALVPPWT RVYRVQRDIP MPLVSSGVEH GNLRELAFAR MKDLGIQCRD 400
    VRTREVGIQE IHHKVRPYQV ELVRRDYVAN GGWETFLSYE DPDQDILIGL 450
    LRLRKCSEET FRFELVGGVS IVRELHVYGS VVPVSSRDPT KFQHQGFGML 500
    LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP YMVKTLE 547
    Length:547
    Mass (Da):62,331
    Last modified:April 17, 2007 - v2
    Checksum:i1B2F2B06FA019F81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105500 mRNA. Translation: AAI05501.2.
    RefSeqiNP_001124234.1. NM_001130762.1.
    UniGeneiBt.4295.

    Genome annotation databases

    EnsembliENSBTAT00000003541; ENSBTAP00000003541; ENSBTAG00000002730.
    GeneIDi784720.
    KEGGibta:784720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105500 mRNA. Translation: AAI05501.2 .
    RefSeqi NP_001124234.1. NM_001130762.1.
    UniGenei Bt.4295.

    3D structure databases

    ProteinModelPortali Q2KJ61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000003541.

    Proteomic databases

    PRIDEi Q2KJ61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000003541 ; ENSBTAP00000003541 ; ENSBTAG00000002730 .
    GeneIDi 784720.
    KEGGi bta:784720.

    Organism-specific databases

    CTDi 55140.

    Phylogenomic databases

    eggNOGi COG1243.
    GeneTreei ENSGT00390000013141.
    HOGENOMi HOG000227514.
    HOVERGENi HBG107845.
    InParanoidi Q2KJ61.
    KOi K07739.
    OMAi GYKVVSH.
    OrthoDBi EOG7V765W.
    TreeFami TF105752.

    Enzyme and pathway databases

    Reactomei REACT_219482. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 20926857.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal liver.

    Entry informationi

    Entry nameiELP3_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJ61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3