ID   IMPA3_BOVIN             Reviewed;         362 AA.
AC   Q2KJ53;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Inositol monophosphatase 3;
DE            EC=3.1.3.25;
DE   AltName: Full=Inositol-1(or 4)-monophosphatase 3;
DE            Short=IMPase 3;
DE            Short=IMP 3;
DE   AltName: Full=Myo-inositol monophosphatase A3;
DE   AltName: Full=Inositol monophosphatase domain-containing protein 1;
GN   Name=IMPAD1; Synonyms=IMPA3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol
CC       + phosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-
CC       inositol from D-glucose 6-phosphate: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the inositol monophosphatase family.
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DR   EMBL; BC105514; AAI05515.1; -; mRNA.
DR   IPI; IPI00699027; -.
DR   RefSeq; NP_001039800.1; -.
DR   UniGene; Bt.12649; -.
DR   Ensembl; ENSBTAG00000015637; Bos taurus.
DR   GeneID; 532797; -.
DR   KEGG; bta:532797; -.
DR   HOVERGEN; Q2KJ53; -.
DR   BRENDA; 3.1.3.25; 251.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008934; F:inositol-1(or 4)-monophosphatase activity; IEA:EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR000760; Inositol_P.
DR   PANTHER; PTHR20854; Inositol_P; 1.
DR   Pfam; PF00459; Inositol_P; 1.
DR   PRINTS; PR00378; INOSPHPHTASE.
DR   PROSITE; PS00629; IMP_1; FALSE_NEG.
DR   PROSITE; PS00630; IMP_2; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Membrane; Metal-binding; Transmembrane.
FT   CHAIN         1    362       Inositol monophosphatase 3.
FT                                /FTId=PRO_0000289040.
FT   TRANSMEM     13     33       Potential.
FT   METAL       136    136       Magnesium 1 (By similarity).
FT   METAL       177    177       Magnesium 1 (By similarity).
FT   METAL       177    177       Magnesium 2 (By similarity).
FT   METAL       179    179       Magnesium 1; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       180    180       Magnesium 2 (By similarity).
FT   METAL       303    303       Magnesium 2 (By similarity).
SQ   SEQUENCE   362 AA;  38924 MW;  2F8EBBE45DB03520 CRC64;
     MAPMGIRLSP LGVAVFCLLG LGVLYHLYSG FLAGRFSLFG LGGEPGGGAA GPAGPAASAD
     GGTVDLREML AVSVLAAVRG GEEVRRVRES NVLHEKSKGK TREGADDKMT SGDVLSNRKM
     FYLLKTAFPS VQINTEEHVD ASDQEVILWD RKIPEDILKE IATPQEVPAE SVTVWIDPLD
     ATQEYTEDLR KYVTTMVCVA VNGKPVLGVI HKPFSEYTAW AMVDGGSNVK ARTSYNEKTP
     RIVVSRSHSG MVKQVALQTF GNQTTIIPAG GAGYKVLALL DVPDKSQEKA DLYIHVTYIK
     KWDICAGNAI LKALGGHMTT LSGEEISYTG SDGIEGGLLA SIRMNHQALV RKLPDLEKTG
     HK
//