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Protein

Inositol monophosphatase 3

Gene

IMPAD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.By similarity

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.

Cofactori

Mg2+By similarity

Enzyme regulationi

Strongly inhibited by lithium.By similarity

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (ISYNA1)
  2. Inositol monophosphatase 3 (IMPAD1), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase (IMPA2), Inositol monophosphatase 1 (IMPA1)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi136Magnesium 1By similarity1
Binding sitei136SubstrateBy similarity1
Metal bindingi177Magnesium 1By similarity1
Metal bindingi177Magnesium 2By similarity1
Metal bindingi179Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi180Magnesium 2By similarity1
Metal bindingi303Magnesium 2By similarity1
Binding sitei303SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-156584 Cytosolic sulfonation of small molecules
UniPathwayiUPA00823; UER00788

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol monophosphatase 3 (EC:3.1.3.25, EC:3.1.3.7)
Short name:
IMP 3
Short name:
IMPase 3
Alternative name(s):
Inositol monophosphatase domain-containing protein 1
Inositol-1(or 4)-monophosphatase 3
Myo-inositol monophosphatase A3
Gene namesi
Name:IMPAD1
Synonyms:IMPA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:30187 IMPAD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 362LumenalSequence analysisAdd BLAST329

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002890401 – 362Inositol monophosphatase 3Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Contains N-linked glycan resistant to endoglycosydase H.By similarity

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ2KJ53
PRIDEiQ2KJ53

Expressioni

Gene expression databases

BgeeiENSBTAG00000015637

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020766

Structurei

3D structure databases

ProteinModelPortaliQ2KJ53
SMRiQ2KJ53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 182Substrate bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3853 Eukaryota
COG1218 LUCA
GeneTreeiENSGT00530000063462
HOGENOMiHOG000290671
HOVERGENiHBG062091
InParanoidiQ2KJ53
KOiK15759
OMAiGQTAWAW
OrthoDBiEOG091G0RCH
TreeFamiTF314300

Family and domain databases

InterProiView protein in InterPro
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PROSITEiView protein in PROSITE
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KJ53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPMGIRLSP LGVAVFCLLG LGVLYHLYSG FLAGRFSLFG LGGEPGGGAA
60 70 80 90 100
GPAGPAASAD GGTVDLREML AVSVLAAVRG GEEVRRVRES NVLHEKSKGK
110 120 130 140 150
TREGADDKMT SGDVLSNRKM FYLLKTAFPS VQINTEEHVD ASDQEVILWD
160 170 180 190 200
RKIPEDILKE IATPQEVPAE SVTVWIDPLD ATQEYTEDLR KYVTTMVCVA
210 220 230 240 250
VNGKPVLGVI HKPFSEYTAW AMVDGGSNVK ARTSYNEKTP RIVVSRSHSG
260 270 280 290 300
MVKQVALQTF GNQTTIIPAG GAGYKVLALL DVPDKSQEKA DLYIHVTYIK
310 320 330 340 350
KWDICAGNAI LKALGGHMTT LSGEEISYTG SDGIEGGLLA SIRMNHQALV
360
RKLPDLEKTG HK
Length:362
Mass (Da):38,924
Last modified:March 7, 2006 - v1
Checksum:i2F8EBBE45DB03520
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105514 mRNA Translation: AAI05515.1
RefSeqiNP_001039800.1, NM_001046335.1
UniGeneiBt.12649

Genome annotation databases

EnsembliENSBTAT00000020766; ENSBTAP00000020766; ENSBTAG00000015637
GeneIDi532797
KEGGibta:532797

Similar proteinsi

Entry informationi

Entry nameiIMPA3_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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