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Reviewed, UniProtKB/Swiss-Prot Q2KJ53 (IMPA3_BOVIN)

Last modified October 13, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Inositol monophosphatase 3
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 3
      Short name=IMPase 3
      Short name=IMP 3
    Myo-inositol monophosphatase A3
    Inositol monophosphatase domain-containing protein 1
Gene names
Name: IMPAD1
Synonyms: IMPA3
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the inositol monophosphatase family.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioninositol-1(or 4)-monophosphatase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Inositol monophosphatase 3
PRO_0000289040

Regions

Transmembrane13 – 3321 Potential
Region179 – 1824Substrate binding By similarity

Sites

Metal binding1361Magnesium 1 By similarity
Metal binding1771Magnesium 1 By similarity
Metal binding1771Magnesium 2 By similarity
Metal binding1791Magnesium 1; via carbonyl oxygen By similarity
Metal binding1801Magnesium 2 By similarity
Metal binding3031Magnesium 2 By similarity
Binding site1361Substrate By similarity
Binding site3031Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q2KJ53-1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 2F8EBBE45DB03520

FASTA36238,924
        10         20         30         40         50         60 
MAPMGIRLSP LGVAVFCLLG LGVLYHLYSG FLAGRFSLFG LGGEPGGGAA GPAGPAASAD 

        70         80         90        100        110        120 
GGTVDLREML AVSVLAAVRG GEEVRRVRES NVLHEKSKGK TREGADDKMT SGDVLSNRKM 

       130        140        150        160        170        180 
FYLLKTAFPS VQINTEEHVD ASDQEVILWD RKIPEDILKE IATPQEVPAE SVTVWIDPLD 

       190        200        210        220        230        240 
ATQEYTEDLR KYVTTMVCVA VNGKPVLGVI HKPFSEYTAW AMVDGGSNVK ARTSYNEKTP 

       250        260        270        280        290        300 
RIVVSRSHSG MVKQVALQTF GNQTTIIPAG GAGYKVLALL DVPDKSQEKA DLYIHVTYIK 

       310        320        330        340        350        360 
KWDICAGNAI LKALGGHMTT LSGEEISYTG SDGIEGGLLA SIRMNHQALV RKLPDLEKTG 


HK

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Ascending colon.

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Cross-references

Sequence databases

BC105514 mRNA. Translation: AAI05515.1.
IPIIPI00699027.
RefSeqNP_001039800.1.
UniGeneBt.12649

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAT00000020766; ENSBTAP00000020766; ENSBTAG00000015637; Bos taurus. [Genome view]
GeneID532797.
KEGGbta:532797.

Organism-specific databases

CTD532797.

Phylogenomic databases

HOVERGENQ2KJ53.

Enzyme and pathway databases

BRENDA3.1.3.25. 251.

Family and domain databases

InterProIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEPS00629. IMP_1. False negative.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameIMPA3_BOVIN
AccessionPrimary (citable) accession number: Q2KJ53
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: October 13, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents