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Protein

Angiopoietin-related protein 4

Gene

ANGPTL4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 4
Alternative name(s):
Angiopoietin-like protein 4
Gene namesi
Name:ANGPTL4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000024442124 – 410Angiopoietin-related protein 4Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi195 ↔ 223
Disulfide bondi348 ↔ 361

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2KJ51.
PRIDEiQ2KJ51.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002473.

Interactioni

Subunit structurei

Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003204.

Structurei

3D structure databases

ProteinModelPortaliQ2KJ51.
SMRiQ2KJ51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 408Fibrinogen C-terminalAdd BLAST223

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 155Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00890000139379.
HOGENOMiHOG000015386.
HOVERGENiHBG001644.
InParanoidiQ2KJ51.
KOiK08767.
OMAiSTWDQDH.
OrthoDBiEOG091G03M1.
TreeFamiTF329953.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiView protein in InterPro
IPR028793. ANGPTL4.
IPR036056. Fibrinogen-like_C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
PANTHERiPTHR19143:SF256. PTHR19143:SF256. 1 hit.
PfamiView protein in Pfam
PF00147. Fibrinogen_C. 1 hit.
SMARTiView protein in SMART
SM00186. FBG. 1 hit.
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiView protein in PROSITE
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJ51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCAPTAGAA LMLCAATAGL LSAQGRPEPP ETPRFASWDE VNVLAHGLLQ
60 70 80 90 100
LGHGLREHVE RTRGQLGELE RRLGACGAAC KDPEGSAAPP RAQANLVNPG
110 120 130 140 150
GGDASPETLR SLKTQLEAQN SRIQQLFQKV AQQQRHLEKQ QLRIQNLQSQ
160 170 180 190 200
MDHLAPRHLG HEMAKPARRK RLPKMAQLAG PAHNISRLHR LPRDCQELFE
210 220 230 240 250
EGERESGLFQ IQPQGSPPFL VNCKMTSDGG WTVIQRRQDG SVDFNQPWEA
260 270 280 290 300
YKDGFGDPQG EFWLGLEKVH HILGDRGSRL AVQLQDWEGN AESLQFPIHL
310 320 330 340 350
GGEDTAYSLQ LTPPVASKLG ATTFSPSGLS LPFSTWDQDH DLRGDKNCAR
360 370 380 390 400
SLSGGWWFGT CSHSNLNGQY FHSIPRQRQQ RKKGIFWKTW RGRYYPLQAT
410
TILVQPTAAS
Length:410
Mass (Da):45,553
Last modified:March 7, 2006 - v1
Checksum:i932B5F43B268EC19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355521 mRNA. Translation: ABC84490.1.
BC105516 mRNA. Translation: AAI05517.1.
RefSeqiNP_001039508.1. NM_001046043.2.
UniGeneiBt.4816.

Genome annotation databases

EnsembliENSBTAT00000003204; ENSBTAP00000003204; ENSBTAG00000002473.
GeneIDi509963.
KEGGibta:509963.

Similar proteinsi

Entry informationi

Entry nameiANGL4_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome