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Protein

Angiopoietin-related protein 4

Gene

ANGPTL4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 4
Alternative name(s):
Angiopoietin-like protein 4
Gene namesi
Name:ANGPTL4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

  • Secreted By similarity
  • Secretedextracellular spaceextracellular matrix By similarity

  • Note: The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 410387Angiopoietin-related protein 4PRO_0000244421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Disulfide bondi195 ↔ 223PROSITE-ProRule annotation
Disulfide bondi348 ↔ 361PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2KJ51.
PRIDEiQ2KJ51.

Interactioni

Subunit structurei

Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003204.

Structurei

3D structure databases

ProteinModelPortaliQ2KJ51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 408223Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 15549Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000015386.
HOVERGENiHBG001644.
InParanoidiQ2KJ51.
KOiK08767.
OMAiVDFNRPW.
OrthoDBiEOG7X9G60.
TreeFamiTF329953.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028793. ANGPTL4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF256. PTHR19143:SF256. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJ51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCAPTAGAA LMLCAATAGL LSAQGRPEPP ETPRFASWDE VNVLAHGLLQ
60 70 80 90 100
LGHGLREHVE RTRGQLGELE RRLGACGAAC KDPEGSAAPP RAQANLVNPG
110 120 130 140 150
GGDASPETLR SLKTQLEAQN SRIQQLFQKV AQQQRHLEKQ QLRIQNLQSQ
160 170 180 190 200
MDHLAPRHLG HEMAKPARRK RLPKMAQLAG PAHNISRLHR LPRDCQELFE
210 220 230 240 250
EGERESGLFQ IQPQGSPPFL VNCKMTSDGG WTVIQRRQDG SVDFNQPWEA
260 270 280 290 300
YKDGFGDPQG EFWLGLEKVH HILGDRGSRL AVQLQDWEGN AESLQFPIHL
310 320 330 340 350
GGEDTAYSLQ LTPPVASKLG ATTFSPSGLS LPFSTWDQDH DLRGDKNCAR
360 370 380 390 400
SLSGGWWFGT CSHSNLNGQY FHSIPRQRQQ RKKGIFWKTW RGRYYPLQAT
410
TILVQPTAAS
Length:410
Mass (Da):45,553
Last modified:March 7, 2006 - v1
Checksum:i932B5F43B268EC19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355521 mRNA. Translation: ABC84490.1.
BC105516 mRNA. Translation: AAI05517.1.
RefSeqiNP_001039508.1. NM_001046043.2.
UniGeneiBt.4816.

Genome annotation databases

EnsembliENSBTAT00000003204; ENSBTAP00000003204; ENSBTAG00000002473.
GeneIDi509963.
KEGGibta:509963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355521 mRNA. Translation: ABC84490.1.
BC105516 mRNA. Translation: AAI05517.1.
RefSeqiNP_001039508.1. NM_001046043.2.
UniGeneiBt.4816.

3D structure databases

ProteinModelPortaliQ2KJ51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003204.

Proteomic databases

PaxDbiQ2KJ51.
PRIDEiQ2KJ51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003204; ENSBTAP00000003204; ENSBTAG00000002473.
GeneIDi509963.
KEGGibta:509963.

Organism-specific databases

CTDi51129.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000015386.
HOVERGENiHBG001644.
InParanoidiQ2KJ51.
KOiK08767.
OMAiVDFNRPW.
OrthoDBiEOG7X9G60.
TreeFamiTF329953.

Miscellaneous databases

NextBioi20869216.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028793. ANGPTL4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF256. PTHR19143:SF256. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ma Y., Xu S.-Z., Zhang Y.-H., Gao X., Ren H.-Y., Xin Y.-P., Gao S.-X.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiANGL4_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: February 17, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.