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Protein

Serine/threonine-protein phosphatase 2A activator

Gene

PPP2R4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg2+ (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg2+ (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 1547ATPBy similarity
Nucleotide bindingi205 – 2073ATPBy similarity
Nucleotide bindingi307 – 3082ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator (EC:5.2.1.8)
Alternative name(s):
PP2A, subunit B', PR53 isoform
Phosphotyrosyl phosphatase activator
Short name:
PTPA
Serine/threonine-protein phosphatase 2A regulatory subunit 4
Serine/threonine-protein phosphatase 2A regulatory subunit B'
Gene namesi
Name:PPP2R4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 324323Serine/threonine-protein phosphatase 2A activatorPRO_0000328834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KJ44.
PRIDEiQ2KJ44.

Interactioni

Subunit structurei

Associates with the serine/threonine-protein phosphatase 2A PP2A(D) heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032642.

Structurei

3D structure databases

ProteinModelPortaliQ2KJ44.
SMRiQ2KJ44. Positions 22-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPA-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG2867. Eukaryota.
COG5057. LUCA.
GeneTreeiENSGT00390000011500.
HOGENOMiHOG000205736.
HOVERGENiHBG019168.
InParanoidiQ2KJ44.
KOiK17605.
OMAiTGHEMAF.
OrthoDBiEOG7KQ21W.
TreeFamiTF105555.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGERQTPS DSSEDAPPTT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG
60 70 80 90 100
FILTLNEGVK GKKLSFEYKV SEAIEKLVAL LNTLDRWIDE TPPVDQPSRF
110 120 130 140 150
GNKAYRTWYA KLDQEAENLV ATVVPTNLAA AVPEVAVYLK ESVGNSTRID
160 170 180 190 200
YGTGHEAAFA AFLCCLCKIG VLRVDDQIAI VFKVFNRYLE VMRKLQKTYR
210 220 230 240 250
MEPAGSQGVW GLDDFQFLPF IWGSSQLIDH PYLEPRHFVD EKAVNENHKD
260 270 280 290 300
YMFLECILFI TEMKTGPFAE HSNQLWNISA VPSWSKVNQG LIRMYKAECL
310 320
EKFPVIQHFK FGSLLPIHPV MSSC
Length:324
Mass (Da):36,882
Last modified:March 7, 2006 - v1
Checksum:i5FCFB21DE2DBA1CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105529 mRNA. Translation: AAI05530.1.
RefSeqiNP_001039638.1. NM_001046173.1.
UniGeneiBt.5138.

Genome annotation databases

EnsembliENSBTAT00000032713; ENSBTAP00000032642; ENSBTAG00000001933.
GeneIDi514460.
KEGGibta:514460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105529 mRNA. Translation: AAI05530.1.
RefSeqiNP_001039638.1. NM_001046173.1.
UniGeneiBt.5138.

3D structure databases

ProteinModelPortaliQ2KJ44.
SMRiQ2KJ44. Positions 22-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032642.

Proteomic databases

PaxDbiQ2KJ44.
PRIDEiQ2KJ44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000032713; ENSBTAP00000032642; ENSBTAG00000001933.
GeneIDi514460.
KEGGibta:514460.

Organism-specific databases

CTDi5524.

Phylogenomic databases

eggNOGiKOG2867. Eukaryota.
COG5057. LUCA.
GeneTreeiENSGT00390000011500.
HOGENOMiHOG000205736.
HOVERGENiHBG019168.
InParanoidiQ2KJ44.
KOiK17605.
OMAiTGHEMAF.
OrthoDBiEOG7KQ21W.
TreeFamiTF105555.

Miscellaneous databases

NextBioi20871347.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiPTPA_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 7, 2006
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.