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Protein

Serine/threonine-protein phosphatase 2A activator

Gene

PTPA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg2+ (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg2+ (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi148 – 154ATPBy similarity7
Nucleotide bindingi205 – 207ATPBy similarity3
Nucleotide bindingi307 – 308ATPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator (EC:5.2.1.8)
Alternative name(s):
PP2A, subunit B', PR53 isoform
Phosphotyrosyl phosphatase activator
Short name:
PTPA
Serine/threonine-protein phosphatase 2A regulatory subunit 4
Serine/threonine-protein phosphatase 2A regulatory subunit B'
Gene namesi
Name:PTPA
Synonyms:PPP2R4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:33526 PTPA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003288342 – 324Serine/threonine-protein phosphatase 2A activatorAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KJ44
PeptideAtlasiQ2KJ44
PRIDEiQ2KJ44

Expressioni

Gene expression databases

BgeeiENSBTAG00000001933

Interactioni

Subunit structurei

Associates with the serine/threonine-protein phosphatase 2A PP2A(D) heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032642

Structurei

3D structure databases

ProteinModelPortaliQ2KJ44
SMRiQ2KJ44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPA-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG2867 Eukaryota
COG5057 LUCA
GeneTreeiENSGT00390000011500
HOGENOMiHOG000205736
HOVERGENiHBG019168
InParanoidiQ2KJ44
KOiK17605
OMAiMRRMFVA
OrthoDBiEOG091G0ITS
TreeFamiTF105555

Family and domain databases

CDDicd04087 PTPA, 1 hit
InterProiView protein in InterPro
IPR004327 Phstyr_phstse_ac
IPR037218 PTPA_sf
PANTHERiPTHR10012 PTHR10012, 1 hit
PfamiView protein in Pfam
PF03095 PTPA, 1 hit
PIRSFiPIRSF016325 Phstyr_phstse_ac, 1 hit
SUPFAMiSSF140984 SSF140984, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGERQTPS DSSEDAPPTT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG
60 70 80 90 100
FILTLNEGVK GKKLSFEYKV SEAIEKLVAL LNTLDRWIDE TPPVDQPSRF
110 120 130 140 150
GNKAYRTWYA KLDQEAENLV ATVVPTNLAA AVPEVAVYLK ESVGNSTRID
160 170 180 190 200
YGTGHEAAFA AFLCCLCKIG VLRVDDQIAI VFKVFNRYLE VMRKLQKTYR
210 220 230 240 250
MEPAGSQGVW GLDDFQFLPF IWGSSQLIDH PYLEPRHFVD EKAVNENHKD
260 270 280 290 300
YMFLECILFI TEMKTGPFAE HSNQLWNISA VPSWSKVNQG LIRMYKAECL
310 320
EKFPVIQHFK FGSLLPIHPV MSSC
Length:324
Mass (Da):36,882
Last modified:March 7, 2006 - v1
Checksum:i5FCFB21DE2DBA1CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105529 mRNA Translation: AAI05530.1
RefSeqiNP_001039638.1, NM_001046173.1
UniGeneiBt.5138

Genome annotation databases

EnsembliENSBTAT00000032713; ENSBTAP00000032642; ENSBTAG00000001933
GeneIDi514460
KEGGibta:514460

Similar proteinsi

Entry informationi

Entry nameiPTPA_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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