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Q2KJ39 (RCN3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Reticulocalbin-3
Gene names
Name:RCN3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the CREC family.

Contains 6 EF-hand domains.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Metal-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 328308Reticulocalbin-3
PRO_0000240340

Regions

Domain75 – 11238EF-hand 1
Domain113 – 14836EF-hand 2
Domain163 – 19836EF-hand 3
Domain200 – 23536EF-hand 4
Domain241 – 27636EF-hand 5
Domain277 – 31236EF-hand 6
Calcium binding90 – 101121; possibly ancestral Potential
Calcium binding126 – 137122 Potential
Calcium binding176 – 187123; possibly ancestral Potential
Calcium binding213 – 224124 Potential
Calcium binding254 – 265125 Potential
Calcium binding290 – 301126 Potential
Motif325 – 3284Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2KJ39 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 4D5FB9AF2D81FAEA

FASTA32837,568
        10         20         30         40         50         60 
MMWPPSLLLL LLLLRRGAQG KPSPDAGPHG QGRVHHAAPL SEAPHDDAHG NFQYDHEAFL 

        70         80         90        100        110        120 
GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA ELRSWIAHTQ QRHIRDSVSA 

       130        140        150        160        170        180 
AWNTYDTDRD GRVGWEELRN ATYGHYEPGE EFHDVEDAET YKKMLARDER RFRVADQDGD 

       190        200        210        220        230        240 
SMATREELTA FLHPEEFPHM RDIVIAETLE DLDRNKDGYV QVEEYIADLY TAEPGEEEPA 

       250        260        270        280        290        300 
WVQTEREQFR DFRDLNKDGK LNGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA 

       310        320 
EILGNWNMFV GSQATNYGED LTRHHDEL

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC105535 mRNA. Translation: AAI05536.1.
IPIIPI00708234.
RefSeqNP_001039725.1. NM_001046260.1.
UniGeneBt.48738.

3D structure databases

ProteinModelPortalQ2KJ39.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000031823.

Proteomic databases

PRIDEQ2KJ39.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000031877; ENSBTAP00000031823; ENSBTAG00000021799.
GeneID522073.
KEGGbta:522073.

Organism-specific databases

CTD57333.

Phylogenomic databases

eggNOGNOG286499.
GeneTreeENSGT00550000074546.
HOGENOMHOG000230934.
HOVERGENHBG002834.
InParanoidQ2KJ39.
OMASDAPHDD.
OrthoDBEOG4DJJWQ.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13202. EF_hand_3. 1 hit.
PF13499. EF_hand_5. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20873441.

Entry information

Entry nameRCN3_BOVIN
AccessionPrimary (citable) accession number: Q2KJ39
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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