Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Reticulocalbin-3

Gene

RCN3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi90 – 1011; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi126 – 1372PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi176 – 1873; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi213 – 2244PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi254 – 2655PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi290 – 3016PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-3
Gene namesi
Name:RCN3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000024034021 – 328Reticulocalbin-3Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi262N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2KJ39.
PRIDEiQ2KJ39.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021799.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031823.

Structurei

3D structure databases

ProteinModelPortaliQ2KJ39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 112EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini113 – 148EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini163 – 198EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini200 – 235EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini241 – 276EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini277 – 312EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi325 – 328Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ2KJ39.
OMAiLSNWNMF.
OrthoDBiEOG091G0GUL.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KJ39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWPPSLLLL LLLLRRGAQG KPSPDAGPHG QGRVHHAAPL SEAPHDDAHG
60 70 80 90 100
NFQYDHEAFL GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA
110 120 130 140 150
ELRSWIAHTQ QRHIRDSVSA AWNTYDTDRD GRVGWEELRN ATYGHYEPGE
160 170 180 190 200
EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM
210 220 230 240 250
RDIVIAETLE DLDRNKDGYV QVEEYIADLY TAEPGEEEPA WVQTEREQFR
260 270 280 290 300
DFRDLNKDGK LNGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA
310 320
EILGNWNMFV GSQATNYGED LTRHHDEL
Length:328
Mass (Da):37,568
Last modified:March 7, 2006 - v1
Checksum:i4D5FB9AF2D81FAEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105535 mRNA. Translation: AAI05536.1.
RefSeqiNP_001039725.1. NM_001046260.1.
UniGeneiBt.48738.

Genome annotation databases

EnsembliENSBTAT00000031877; ENSBTAP00000031823; ENSBTAG00000021799.
GeneIDi522073.
KEGGibta:522073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105535 mRNA. Translation: AAI05536.1.
RefSeqiNP_001039725.1. NM_001046260.1.
UniGeneiBt.48738.

3D structure databases

ProteinModelPortaliQ2KJ39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031823.

Proteomic databases

PaxDbiQ2KJ39.
PRIDEiQ2KJ39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000031877; ENSBTAP00000031823; ENSBTAG00000021799.
GeneIDi522073.
KEGGibta:522073.

Organism-specific databases

CTDi57333.

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ2KJ39.
OMAiLSNWNMF.
OrthoDBiEOG091G0GUL.
TreeFamiTF314849.

Gene expression databases

BgeeiENSBTAG00000021799.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCN3_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.