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Q2KJ36

- DUS6_BOVIN

UniProt

Q2KJ36 - DUS6_BOVIN

Protein

Dual specificity protein phosphatase 6

Gene

DUSP6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Inactivates MAP kinases. Has a specificity for the ERK family By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei293 – 2931Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: Ensembl
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dorsal/ventral pattern formation Source: RefGenome
    2. negative regulation of ERK1 and ERK2 cascade Source: RefGenome
    3. positive regulation of apoptotic process Source: RefGenome
    4. protein dephosphorylation Source: RefGenome
    5. regulation of endodermal cell fate specification Source: RefGenome
    6. regulation of fibroblast growth factor receptor signaling pathway Source: RefGenome
    7. regulation of heart growth Source: RefGenome
    8. response to nitrosative stress Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_220398. ERKs are inactivated.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 6 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:DUSP6
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Dual specificity protein phosphatase 6PRO_0000281919Add
    BLAST

    Proteomic databases

    PRIDEiQ2KJ36.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000006022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJ36.
    SMRiQ2KJ36. Positions 1-154, 205-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 148119RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini206 – 381176Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117282.
    HOGENOMiHOG000294079.
    HOVERGENiHBG007347.
    InParanoidiQ2KJ36.
    KOiK04459.
    OMAiSEWNENT.
    OrthoDBiEOG793B7W.
    TreeFamiTF105122.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSiPR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KJ36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI    50
    ESAINVAIPG IMLRRLQKGS LPVRALFTRG EDRDRFTRRC GTDTVVLYDE 100
    SSSDWNENTG GESVLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFALHCETN 150
    LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS 200
    NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA 250
    GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS 300
    VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS 350
    SPCDNRVPTQ QLYFTTPSNQ NVYQVDSLQS T 381
    Length:381
    Mass (Da):42,307
    Last modified:March 7, 2006 - v1
    Checksum:i15BD1500AAA88DA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025424 mRNA. Translation: ABF57380.1.
    BC105538 mRNA. Translation: AAI05539.1.
    RefSeqiNP_001039660.1. NM_001046195.1.
    UniGeneiBt.11909.

    Genome annotation databases

    EnsembliENSBTAT00000006022; ENSBTAP00000006022; ENSBTAG00000004587.
    GeneIDi515310.
    KEGGibta:515310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025424 mRNA. Translation: ABF57380.1 .
    BC105538 mRNA. Translation: AAI05539.1 .
    RefSeqi NP_001039660.1. NM_001046195.1.
    UniGenei Bt.11909.

    3D structure databases

    ProteinModelPortali Q2KJ36.
    SMRi Q2KJ36. Positions 1-154, 205-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000006022.

    Proteomic databases

    PRIDEi Q2KJ36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000006022 ; ENSBTAP00000006022 ; ENSBTAG00000004587 .
    GeneIDi 515310.
    KEGGi bta:515310.

    Organism-specific databases

    CTDi 1848.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117282.
    HOGENOMi HOG000294079.
    HOVERGENi HBG007347.
    InParanoidi Q2KJ36.
    KOi K04459.
    OMAi SEWNENT.
    OrthoDBi EOG793B7W.
    TreeFami TF105122.

    Enzyme and pathway databases

    Reactomei REACT_220398. ERKs are inactivated.

    Miscellaneous databases

    NextBioi 20871762.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSi PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiDUS6_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJ36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3