Reviewed, UniProtKB/Swiss-Prot Q2KJ28 (PGPS1_BOVIN)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase 1
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:

PGS1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Enzyme regulation	Activated by calcium and magnesium and inhibited by other bivalent cations By similarity.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-II family. Contains 2 PLD phosphodiesterase domains.
Sequence caution	The sequence AAI05552.1 differs from that shown. Reason: Frameshift at position 101.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Domain	Repeat Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion Potential
	Chain	29 – 556	528	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial		PRO_0000337104
Regions
	Domain	215 – 241	27	PLD phosphodiesterase 1
	Domain	419 – 457	39	PLD phosphodiesterase 2
	Nucleotide binding	124 – 131	8	ATP Potential
Sites
	Active site	220	1	Potential
	Active site	222	1	Potential
	Active site	227	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2KJ28-1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: B5BFE926E0906B00	FASTA	556	62,732
	10 20 30 40 50 60 MAAAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NPDRRRRRSP WLLLAPLLSP 70 80 90 100 110 120 AVPVVTSPPC CLCAEGVHRF QWIRNLVPEF GVSSSHVRVL SSPAEFFELM KGQIKVAKRR 130 140 150 160 170 180 VVMASLYLGI GPLEQELVDC LESTLEKSLQ AKFPSGLRVS ILLDFTRGSR GRKNSRTMLL 190 200 210 220 230 240 PLLQRFPEQV RVSLFHTPNL RGLLRLLIPE RFNETIGLQH IKVYLFDNNV ILSGANLSDS 250 260 270 280 290 300 YFTNRQDRYV FLQDCPEIAD FFTELVDAVG DVSLQLQGDD TVQMVEGMVH PYKGDRAAYC 310 320 330 340 350 360 RAANKRVMDV INSARMRQQM LHAQTFHSDP LLTQEDAAAA GDRRPAPDTW IYPLIQMKPF 370 380 390 400 410 420 EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL GTRAEYQILL ASPEVNGFFG 430 440 450 460 470 480 AKGVAGAIPA AYVHIERQFY SEVCSLGQQE RVQLQEYWRR DWTFHAKGLW LYLAGSSLPC 490 500 510 520 530 540 LTLIGSPNFG YRSVHRDLEA QIAIVTESRA LQQQLHQEQE QLYRRAGVVS SATFEQPSRQ 550 VKLWVKMVTP LIKNFF

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC105551 mRNA. Translation: AAI05552.1. Frameshift.
IPI	IPI00695857.
RefSeq	NP_001039860.2.
UniGene	Bt.12133
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000000897; ENSBTAP00000000897; ENSBTAG00000000675; Bos taurus. [Genome view]
GeneID	535126.
KEGG	bta:535126.
Organism-specific databases
CTD	535126.
Phylogenomic databases
HOVERGEN	Q2KJ28.
Family and domain databases
InterPro	IPR016270. PLipase-D_PtdSer-synthase-type. IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
Pfam	PF00614. PLDc. 2 hits. [Graphical view]
PIRSF	PIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGPS1_BOVIN

Accession

Primary (citable) accession number: Q2KJ28

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	September 1, 2009
This is version 27 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)