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Q2KJ16

- PHKG2_BOVIN

UniProt

Q2KJ16 - PHKG2_BOVIN

Protein

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Gene

PHKG2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM By similarity.By similarity

    Catalytic activityi

    2 ATP + phosphorylase b = 2 ADP + phosphorylase a.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531ATPPROSITE-ProRule annotation
    Active sitei153 – 1531Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 389ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorylase kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycogen biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen metabolism

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_225885. Glycogen breakdown (glycogenolysis).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (EC:2.7.11.19)
    Short name:
    PHK-gamma-LT
    Short name:
    PHK-gamma-T
    Alternative name(s):
    Phosphorylase kinase subunit gamma-2
    Gene namesi
    Name:PHKG2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    GO - Cellular componenti

    1. phosphorylase kinase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Phosphorylase b kinase gamma catalytic chain, liver/testis isoformPRO_0000244591Add
    BLAST

    Proteomic databases

    PRIDEiQ2KJ16.

    Interactioni

    Subunit structurei

    Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KJ16.
    SMRiQ2KJ16. Positions 20-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 291268Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni306 – 33025Calmodulin-binding (domain-N)By similarityAdd
    BLAST
    Regioni346 – 37025Calmodulin-binding (domain-C)By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117716.
    HOGENOMiHOG000233016.
    HOVERGENiHBG106193.
    InParanoidiQ2KJ16.
    KOiK00871.
    OMAiHRPPGPF.
    OrthoDBiEOG7JMGDM.
    TreeFamiTF320349.

    Family and domain databases

    InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR002291. Phosph_kin_gamma.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24347. PTHR24347. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01049. PHOSPHBKNASE.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KJ16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGQEF    50
    AVKIMEVTAE RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS 100
    SFMFLVFDLM RKGELFDYLT EKVALSEKET RSIMRSLLEA VSFLHNNNIV 150
    HRDLKPENIL LDDNMQIRLS DFGFSCHLEP GEKLRELCGT PGYLAPEILK 200
    CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL MLRMIMEGQY 250
    QFSSPEWDDR SDTVKDLISR LLQVDPVERL TAEQALQHPF FERCEGSQAW 300
    NLTPRQRFRV AVWTVLAAGR VALSAHRIRP LTKSALLRDP YALRPVRRLI 350
    DNCAFRLYGH WVKKGEQQNR AALFQHRPPG PFPMMGPEEE GDSATIAEDE 400
    AMLVLG 406
    Length:406
    Mass (Da):46,542
    Last modified:March 7, 2006 - v1
    Checksum:iE0B8F8494DF8A58E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT030706 mRNA. Translation: ABS45022.1.
    BC105568 mRNA. Translation: AAI05569.1.
    RefSeqiNP_001039593.1. NM_001046128.1.
    UniGeneiBt.11190.

    Genome annotation databases

    EnsembliENSBTAT00000004433; ENSBTAP00000004433; ENSBTAG00000003417.
    GeneIDi512670.
    KEGGibta:512670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT030706 mRNA. Translation: ABS45022.1 .
    BC105568 mRNA. Translation: AAI05569.1 .
    RefSeqi NP_001039593.1. NM_001046128.1.
    UniGenei Bt.11190.

    3D structure databases

    ProteinModelPortali Q2KJ16.
    SMRi Q2KJ16. Positions 20-293.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2KJ16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000004433 ; ENSBTAP00000004433 ; ENSBTAG00000003417 .
    GeneIDi 512670.
    KEGGi bta:512670.

    Organism-specific databases

    CTDi 5261.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117716.
    HOGENOMi HOG000233016.
    HOVERGENi HBG106193.
    InParanoidi Q2KJ16.
    KOi K00871.
    OMAi HRPPGPF.
    OrthoDBi EOG7JMGDM.
    TreeFami TF320349.

    Enzyme and pathway databases

    Reactomei REACT_225885. Glycogen breakdown (glycogenolysis).

    Miscellaneous databases

    NextBioi 20870499.

    Family and domain databases

    InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR002291. Phosph_kin_gamma.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24347. PTHR24347. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01049. PHOSPHBKNASE.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon.

    Entry informationi

    Entry nameiPHKG2_BOVIN
    AccessioniPrimary (citable) accession number: Q2KJ16
    Secondary accession number(s): A7E3T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3