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Protein

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Gene

PHKG2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).By similarity

Catalytic activityi

2 ATP + phosphorylase b = 2 ADP + phosphorylase a.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53ATPPROSITE-ProRule annotation1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 38ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCarbohydrate metabolism, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-70221 Glycogen breakdown (glycogenolysis)

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (EC:2.7.11.19)
Short name:
PHK-gamma-LT
Short name:
PHK-gamma-T
Alternative name(s):
Phosphorylase kinase subunit gamma-2
Gene namesi
Name:PHKG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:32834 PHKG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445911 – 406Phosphorylase b kinase gamma catalytic chain, liver/testis isoformAdd BLAST406

Proteomic databases

PaxDbiQ2KJ16
PRIDEiQ2KJ16

Expressioni

Gene expression databases

BgeeiENSBTAG00000003417

Interactioni

Subunit structurei

Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004433

Structurei

3D structure databases

ProteinModelPortaliQ2KJ16
SMRiQ2KJ16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 291Protein kinasePROSITE-ProRule annotationAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni306 – 330Calmodulin-binding (domain-N)By similarityAdd BLAST25
Regioni346 – 370Calmodulin-binding (domain-C)By similarityAdd BLAST25

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0599 Eukaryota
ENOG410Y7VX LUCA
GeneTreeiENSGT00840000129744
HOGENOMiHOG000233016
HOVERGENiHBG106193
InParanoidiQ2KJ16
KOiK00871
OMAiWHRRQIL
OrthoDBiEOG091G07XZ
TreeFamiTF320349

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR002291 Phosph_kin_gamma
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01049 PHOSPHBKNASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KJ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGQEF
60 70 80 90 100
AVKIMEVTAE RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS
110 120 130 140 150
SFMFLVFDLM RKGELFDYLT EKVALSEKET RSIMRSLLEA VSFLHNNNIV
160 170 180 190 200
HRDLKPENIL LDDNMQIRLS DFGFSCHLEP GEKLRELCGT PGYLAPEILK
210 220 230 240 250
CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL MLRMIMEGQY
260 270 280 290 300
QFSSPEWDDR SDTVKDLISR LLQVDPVERL TAEQALQHPF FERCEGSQAW
310 320 330 340 350
NLTPRQRFRV AVWTVLAAGR VALSAHRIRP LTKSALLRDP YALRPVRRLI
360 370 380 390 400
DNCAFRLYGH WVKKGEQQNR AALFQHRPPG PFPMMGPEEE GDSATIAEDE

AMLVLG
Length:406
Mass (Da):46,542
Last modified:March 7, 2006 - v1
Checksum:iE0B8F8494DF8A58E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030706 mRNA Translation: ABS45022.1
BC105568 mRNA Translation: AAI05569.1
RefSeqiNP_001039593.1, NM_001046128.1
UniGeneiBt.11190

Genome annotation databases

EnsembliENSBTAT00000004433; ENSBTAP00000004433; ENSBTAG00000003417
GeneIDi512670
KEGGibta:512670

Similar proteinsi

Entry informationi

Entry nameiPHKG2_BOVIN
AccessioniPrimary (citable) accession number: Q2KJ16
Secondary accession number(s): A7E3T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health