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Protein

RBPJ-interacting and tubulin-associated protein 1

Gene

Rita1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
RBPJ-interacting and tubulin-associated protein 1
Alternative name(s):
RBPJ-interacting and tubulin-associated protein
Gene namesi
Name:Rita1
Synonyms:Rita
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1306772. Rita1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258RBPJ-interacting and tubulin-associated protein 1PRO_0000294431Add
BLAST

Proteomic databases

PaxDbiQ2KJ10.
PRIDEiQ2KJ10.

Expressioni

Gene expression databases

BgeeiENSRNOG00000037720.
GenevisibleiQ2KJ10. RN.

Interactioni

Subunit structurei

Interacts with RBPJ/RBPSUH.By similarity

GO - Molecular functioni

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 14529Interaction with RBPJ/RBPSUHBy similarityAdd
BLAST
Regioni145 – 258114Interaction with tubulinBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 9717Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the RITA family.Curated

Phylogenomic databases

eggNOGiENOG410IKKU. Eukaryota.
ENOG411251C. LUCA.
GeneTreeiENSGT00390000013005.
HOVERGENiHBG101945.
InParanoidiQ2KJ10.
OMAiFDPPWVE.
OrthoDBiEOG091G0OOF.
PhylomeDBiQ2KJ10.
TreeFamiTF337291.

Family and domain databases

InterProiIPR031418. RITA1.
[Graphical view]
PfamiPF17066. RITA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALHLQHRN PRSYRVKARA SYVDETLFGS PTGTRPTLPD FDPPWVQNCN
60 70 80 90 100
RSRGVSPGPP KVSLAKRDCE SPSSRGSTPN LTPRKKNKYR LIGHTPSYCD
110 120 130 140 150
ESLFGSRPQG TSKERSRTAV EDAAKLRTLF WTPPATPRGS HSPRPRETPL
160 170 180 190 200
RAIHPTGPPR TEPRVATGSQ MVSRDGLDAP RSLGQRRSYS LTHLAVPSTG
210 220 230 240 250
HPASTAPQTN GPWSPRPYTS GATVQSPLVT RKVCSGSVSG PTTPQRGACP

QKPKPPWK
Length:258
Mass (Da):28,148
Last modified:March 7, 2006 - v1
Checksum:iCB48B0F96C0609F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112384 mRNA. Translation: AAI12385.1.
RefSeqiNP_001037691.1. NM_001044226.1.
XP_006249445.1. XM_006249383.2.
XP_006249446.1. XM_006249384.2.
UniGeneiRn.20168.

Genome annotation databases

EnsembliENSRNOT00000057242; ENSRNOP00000054067; ENSRNOG00000037720.
GeneIDi288683.
KEGGirno:288683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112384 mRNA. Translation: AAI12385.1.
RefSeqiNP_001037691.1. NM_001044226.1.
XP_006249445.1. XM_006249383.2.
XP_006249446.1. XM_006249384.2.
UniGeneiRn.20168.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ2KJ10.
PRIDEiQ2KJ10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057242; ENSRNOP00000054067; ENSRNOG00000037720.
GeneIDi288683.
KEGGirno:288683.

Organism-specific databases

CTDi84934.
RGDi1306772. Rita1.

Phylogenomic databases

eggNOGiENOG410IKKU. Eukaryota.
ENOG411251C. LUCA.
GeneTreeiENSGT00390000013005.
HOVERGENiHBG101945.
InParanoidiQ2KJ10.
OMAiFDPPWVE.
OrthoDBiEOG091G0OOF.
PhylomeDBiQ2KJ10.
TreeFamiTF337291.

Miscellaneous databases

PROiQ2KJ10.

Gene expression databases

BgeeiENSRNOG00000037720.
GenevisibleiQ2KJ10. RN.

Family and domain databases

InterProiIPR031418. RITA1.
[Graphical view]
PfamiPF17066. RITA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRITA1_RAT
AccessioniPrimary (citable) accession number: Q2KJ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.