Reviewed, UniProtKB/Swiss-Prot Q2KIZ3 (MCEE_BOVIN)

Names and origin

Protein names

Recommended name:
    Methylmalonyl-CoA epimerase, mitochondrial
    EC=5.1.99.1
Alternative name(s):
    DL-methylmalonyl-CoA racemase

Gene names

Name:

MCEE

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.
Subcellular location	Mitochondrion Probable.
Sequence similarities	Belongs to the glyoxalase I family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Isomerase
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methylmalonyl-CoA epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 35	35	Mitochondrion Potential
	Chain	36 – 175	140	Methylmalonyl-CoA epimerase, mitochondrial		PRO_0000240349

Sequences

	Sequence		Length	Mass (Da)
	Q2KIZ3-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: DB8548CD77EAB207	FASTA	175	18,514
	10 20 30 40 50 60 MARVLKVAAA SAAGLFPRLR TPVSTVRTSA SLSSHPGAGP VWNLGRLNHV AVAVPDLEKA 70 80 90 100 110 120 RAFYKNVLGA EVGEPVPLPE HGVSVVFVNL GNTKMELLHP LGSDSPIAGF LKKNKAGGMH 130 140 150 160 170 HVCIEVDNIN VAVMDLKEKK IRILSEEAKI GAHGKPVIFL HPSDCGGVLV ELEQA

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC112453 mRNA. Translation: AAI12454.1.
IPI	IPI00716680.
RefSeq	NP_001039460.1.
UniGene	Bt.16108
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000035247. Bos taurus. [Contig view]
GeneID	508170.
KEGG	bta:508170.
Phylogenomic databases
HOVERGEN	Q2KIZ3.
OMA	Q2KIZ3. MAPIDES.
Enzyme and pathway databases
BRENDA	5.1.99.1. 251.
Family and domain databases
InterPro	IPR004360. Glyas_bleo-R_dOase. IPR017515. MeMalonyl-CoA_epimerase. [Graphical view]
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
ProDom	PD002334. Gly_diox. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03081. metmalonyl_epim. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCEE_BOVIN

Accession

Primary (citable) accession number: Q2KIZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)