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Protein

Complement C1q subcomponent subunit B

Gene

C1QB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-BTA-166663. Initial triggering of complement.
R-BTA-173623. Classical antibody-mediated complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q subcomponent subunit B
Gene namesi
Name:C1QB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000028613523 – 247Complement C1q subcomponent subunit BAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi26Interchain (with C-26 in chain A)By similarity
Modified residuei294-hydroxyprolineBy similarity1
Modified residuei324-hydroxyprolineBy similarity1
Modified residuei354-hydroxyprolineBy similarity1
Modified residuei474-hydroxyprolineBy similarity1
Modified residuei504-hydroxyprolineBy similarity1
Modified residuei535-hydroxylysineBy similarity1
Modified residuei565-hydroxylysineBy similarity1
Modified residuei594-hydroxyprolineBy similarity1
Modified residuei715-hydroxylysineBy similarity1
Modified residuei774-hydroxyprolineBy similarity1
Modified residuei804-hydroxyprolineBy similarity1
Modified residuei865-hydroxylysineBy similarity1
Modified residuei925-hydroxylysineBy similarity1
Modified residuei954-hydroxyprolineBy similarity1
Modified residuei984-hydroxyprolineBy similarity1
Modified residuei1045-hydroxylysineBy similarity1

Post-translational modificationi

Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Bovine C1Q contains up to 66.3 hydroxylysine-galactosylglucose residues. Total percentage hydroxylysine residues glycosylated is 92.0%. Contains no hydroxylysine-monosaccharides.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ2KIV9.
PRIDEiQ2KIV9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011196.

Interactioni

Subunit structurei

C1 is a calcium-dependent trimolecular complex of C1q, c1r and C1s in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014871.

Structurei

3D structure databases

ProteinModelPortaliQ2KIV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 98Collagen-likeAdd BLAST60
Domaini111 – 247C1qPROSITE-ProRule annotationAdd BLAST137

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ2KIV9.
KOiK03987.
OMAiFFTYHAS.
OrthoDBiEOG091G0L3Y.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPRGSVLV LLLLNLLRVS WAQSNCIRPS IPGIPGIPGK PGSDGKPGTP
60 70 80 90 100
GTKGEKGLPG LVSHLNENGE KGDPGFPGMP GKVGPKGPIG PKGVPGPPGV
110 120 130 140 150
RGPKGESGDY KATQKIAFSA SRTINHHQRQ GQPIRFDHVI TNANENYQAR
160 170 180 190 200
SSKFTCKVPG LYFFTYHASS RGQLCVDLMR GRAEPQKVVT FCDYVQNTFQ
210 220 230 240
VTTGSIVLKL EKDETVFLQA TEKNALVGIE GANSIFSGFM LFPDTEA
Length:247
Mass (Da):26,399
Last modified:March 7, 2006 - v1
Checksum:i4C2CDCFF75A433B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112490 mRNA. Translation: AAI12491.1.
RefSeqiNP_001040064.1. NM_001046599.2.
XP_010800915.1. XM_010802613.1.
UniGeneiBt.20164.

Genome annotation databases

EnsembliENSBTAT00000014871; ENSBTAP00000014871; ENSBTAG00000011196.
GeneIDi617435.
KEGGibta:617435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112490 mRNA. Translation: AAI12491.1.
RefSeqiNP_001040064.1. NM_001046599.2.
XP_010800915.1. XM_010802613.1.
UniGeneiBt.20164.

3D structure databases

ProteinModelPortaliQ2KIV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014871.

Proteomic databases

PaxDbiQ2KIV9.
PRIDEiQ2KIV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014871; ENSBTAP00000014871; ENSBTAG00000011196.
GeneIDi617435.
KEGGibta:617435.

Organism-specific databases

CTDi713.

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ2KIV9.
KOiK03987.
OMAiFFTYHAS.
OrthoDBiEOG091G0L3Y.
TreeFamiTF329591.

Enzyme and pathway databases

ReactomeiR-BTA-166663. Initial triggering of complement.
R-BTA-173623. Classical antibody-mediated complement activation.

Gene expression databases

BgeeiENSBTAG00000011196.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QB_BOVIN
AccessioniPrimary (citable) accession number: Q2KIV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 7, 2006
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.