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Protein

Tetraspanin-8

Gene

TSPAN8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Gene namesi
Name:TSPAN8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 33HelicalSequence analysisAdd BLAST24
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 72HelicalSequence analysisAdd BLAST15
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 109HelicalSequence analysisAdd BLAST26
Topological domaini110 – 206ExtracellularSequence analysisAdd BLAST97
Transmembranei207 – 231HelicalSequence analysisAdd BLAST25
Topological domaini232 – 238CytoplasmicSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849631 – 238Tetraspanin-8Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2KIS9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025875.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ2KIS9.
KOiK17349.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KIS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVNVCIKC SMFIFNFVFW LCGAIILSVA ISIRAGKIGQ EILAPGDADL
60 70 80 90 100
NLFIAVNILI FVGAVIMILG FLGCCGAMKE NQFMMILFFV GLLMILLLQV
110 120 130 140 150
AAGIVATTRK SKTEQALNKT LLINARLLSS TDENERVFQK AFSELQEELK
160 170 180 190 200
CCGLVNGASD WGSNFQHYYR TCECPSESDS SCTKYSGKTI YKQSCFASIS
210 220 230
QMFSKRLFIV LALAFGLAAI EVLGLIFSIV LYCQMRKK
Length:238
Mass (Da):26,208
Last modified:March 7, 2006 - v1
Checksum:i9B8BB87A636641C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112523 mRNA. Translation: AAI12524.1.
RefSeqiNP_001073097.1. NM_001079629.2.
UniGeneiBt.59505.

Genome annotation databases

GeneIDi617508.
KEGGibta:617508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112523 mRNA. Translation: AAI12524.1.
RefSeqiNP_001073097.1. NM_001079629.2.
UniGeneiBt.59505.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025875.

Proteomic databases

PaxDbiQ2KIS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi617508.
KEGGibta:617508.

Organism-specific databases

CTDi7103.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ2KIS9.
KOiK17349.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN8_BOVIN
AccessioniPrimary (citable) accession number: Q2KIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 7, 2006
Last modified: June 8, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.