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Protein

Tetraspanin-8

Gene

TSPAN8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Gene namesi
Name:TSPAN8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 33HelicalSequence analysisAdd BLAST24
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 72HelicalSequence analysisAdd BLAST15
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 109HelicalSequence analysisAdd BLAST26
Topological domaini110 – 206ExtracellularSequence analysisAdd BLAST97
Transmembranei207 – 231HelicalSequence analysisAdd BLAST25
Topological domaini232 – 238CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849631 – 238Tetraspanin-8Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2KIS9
PRIDEiQ2KIS9

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025875

Structurei

3D structure databases

SMRiQ2KIS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ2KIS9
KOiK17349

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KIS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVNVCIKC SMFIFNFVFW LCGAIILSVA ISIRAGKIGQ EILAPGDADL
60 70 80 90 100
NLFIAVNILI FVGAVIMILG FLGCCGAMKE NQFMMILFFV GLLMILLLQV
110 120 130 140 150
AAGIVATTRK SKTEQALNKT LLINARLLSS TDENERVFQK AFSELQEELK
160 170 180 190 200
CCGLVNGASD WGSNFQHYYR TCECPSESDS SCTKYSGKTI YKQSCFASIS
210 220 230
QMFSKRLFIV LALAFGLAAI EVLGLIFSIV LYCQMRKK
Length:238
Mass (Da):26,208
Last modified:March 7, 2006 - v1
Checksum:i9B8BB87A636641C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112523 mRNA Translation: AAI12524.1
RefSeqiNP_001073097.1, NM_001079629.2
UniGeneiBt.59505

Genome annotation databases

GeneIDi617508
KEGGibta:617508

Similar proteinsi

Entry informationi

Entry nameiTSN8_BOVIN
AccessioniPrimary (citable) accession number: Q2KIS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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