Reviewed, UniProtKB/Swiss-Prot Q2KIR8 (TDH_BOVIN)

Names and origin

Protein names

Recommended name:
    L-threonine 3-dehydrogenase, mitochondrial
    EC=1.1.1.103

Gene names

Name:

TDH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. UniProtKB Q8MIR0
Pathway	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.
Subcellular location	Mitochondrion By similarity. UniProtKB Q8MIR0
Sequence similarities	Belongs to the sugar epimerase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-threonine 3-dehydrogenase activity Inferred from electronic annotation. Source: EC coenzyme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential UniProtKB Q8MIR0
	Chain	? – 373		L-threonine 3-dehydrogenase, mitochondrial		PRO_0000298782
Regions
	Nucleotide binding	9 – 46	38	NAD By similarity UniProtKB Q8R059
Sites
	Active site	195	1	Proton acceptor By similarity UniProtKB Q8R059

Sequences

	Sequence		Length	Mass (Da)
	Q2KIR8-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 80395E43DA6270F4	FASTA	373	41,846
	10 20 30 40 50 60 MPVVRVLRRV ACWMLQSPAC GCRAPVLPSR FLGTSPRQIP MDANFHSTSF SEADQQRVLI 70 80 90 100 110 120 TGGLGQLGVG LASFLRKRFG KDNVILSDIR KPPEHVFLSG PFIYSDILDY KNLREIVVNN 130 140 150 160 170 180 RITWLFHYSA LLSAVGEANV SLARAVNITG LHNVLDVAAE HGLRLFVPST IGAFGPTSPR 190 200 210 220 230 240 NPTPDLCIQR PRTIYGVSKV HAELMGEYYY YRYGLDFRCL RYPGIISADS QPGGGTTDYA 250 260 270 280 290 300 VQIFHEAVKN GRFECNLKPD TRLPMMYIDD CLRATLEVME APAESLSMRT YNISAMSFTP 310 320 330 340 350 360 EELAQEVLKH VPELQVTYNV DPVRQAIADS WPMNFDDSNA RKDWGWKHDF DLPELVTTML 370 NFHGSESRVA QAN

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC112535 mRNA. Translation: AAI12536.1.
IPI	IPI00702094.
RefSeq	NP_001039569.1.
UniGene	Bt.22599
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000036775; ENSBTAP00000036630; ENSBTAG00000000011; Bos taurus. [Genome view]
GeneID	511957.
KEGG	bta:511957.
Organism-specific databases
CTD	511957.
Phylogenomic databases
HOVERGEN	Q2KIR8.
OMA	ATLEVME.
Enzyme and pathway databases
BRENDA	1.1.1.103. 251.
Family and domain databases
InterPro	IPR001509. Epimerase_deHydtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TDH_BOVIN

Accession

Primary (citable) accession number: Q2KIR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	March 7, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)