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Protein

C-X-C motif chemokine 10

Gene

CXCL10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
Small-inducible cytokine B10
Gene namesi
Name:CXCL10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 10283C-X-C motif chemokine 10PRO_0000326171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241CitrullineBy similarity
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi30 ↔ 72By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiQ2KIQ8.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039324.

Structurei

3D structure databases

ProteinModelPortaliQ2KIQ8.
SMRiQ2KIQ8. Positions 20-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1VC. Eukaryota.
ENOG410ZTJK. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ2KIQ8.
KOiK12671.
OMAiRCTCIKI.
OrthoDBiEOG7HHWVH.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF47. PTHR10179:SF47. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSGFLIFC LILLTLSQGV PLSRNTRCSC IEISNGSVNP RSLEKLEVIP
60 70 80 90 100
ASQSCPRVEI IATMKKNGEK RCLNPESKTI KNLLKAINKQ RTKRSPRTRK

EA
Length:102
Mass (Da):11,427
Last modified:March 7, 2006 - v1
Checksum:i3371D2CE3A0B67FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU276062 mRNA. Translation: ABX72060.1.
BC112547 mRNA. Translation: AAI12548.1.
RefSeqiNP_001040016.1. NM_001046551.2.
UniGeneiBt.60947.

Genome annotation databases

EnsembliENSBTAT00000039533; ENSBTAP00000039324; ENSBTAG00000001725.
GeneIDi615107.
KEGGibta:615107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU276062 mRNA. Translation: ABX72060.1.
BC112547 mRNA. Translation: AAI12548.1.
RefSeqiNP_001040016.1. NM_001046551.2.
UniGeneiBt.60947.

3D structure databases

ProteinModelPortaliQ2KIQ8.
SMRiQ2KIQ8. Positions 20-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039324.

Proteomic databases

PaxDbiQ2KIQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000039533; ENSBTAP00000039324; ENSBTAG00000001725.
GeneIDi615107.
KEGGibta:615107.

Organism-specific databases

CTDi3627.

Phylogenomic databases

eggNOGiENOG410J1VC. Eukaryota.
ENOG410ZTJK. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ2KIQ8.
KOiK12671.
OMAiRCTCIKI.
OrthoDBiEOG7HHWVH.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF47. PTHR10179:SF47. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiCXL10_BOVIN
AccessioniPrimary (citable) accession number: Q2KIQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 7, 2006
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.