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Protein

C-X-C motif chemokine 10

Gene

CXCL10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-BTA-380108 Chemokine receptors bind chemokines
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
Small-inducible cytokine B10
Gene namesi
Name:CXCL10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:27846 CXCL10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000032617120 – 102C-X-C motif chemokine 10Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24CitrullineBy similarity1
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi30 ↔ 72By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiQ2KIQ8

Expressioni

Gene expression databases

BgeeiENSBTAG00000001725

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039324

Structurei

3D structure databases

ProteinModelPortaliQ2KIQ8
SMRiQ2KIQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1VC Eukaryota
ENOG410ZTJK LUCA
GeneTreeiENSGT00530000063958
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiQ2KIQ8
KOiK12671
OMAiRCTCIKI
OrthoDBiEOG091G0YSL
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSGFLIFC LILLTLSQGV PLSRNTRCSC IEISNGSVNP RSLEKLEVIP
60 70 80 90 100
ASQSCPRVEI IATMKKNGEK RCLNPESKTI KNLLKAINKQ RTKRSPRTRK

EA
Length:102
Mass (Da):11,427
Last modified:March 7, 2006 - v1
Checksum:i3371D2CE3A0B67FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU276062 mRNA Translation: ABX72060.1
BC112547 mRNA Translation: AAI12548.1
RefSeqiNP_001040016.1, NM_001046551.2
UniGeneiBt.60947

Genome annotation databases

EnsembliENSBTAT00000039533; ENSBTAP00000039324; ENSBTAG00000001725
GeneIDi615107
KEGGibta:615107

Entry informationi

Entry nameiCXL10_BOVIN
AccessioniPrimary (citable) accession number: Q2KIQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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