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Q2KIQ4

- COQ2_BOVIN

UniProt

Q2KIQ4 - COQ2_BOVIN

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Protein
4-hydroxybenzoate polyprenyltransferase, mitochondrial
Gene
COQ2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB By similarity.

Catalytic activityi

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.

Pathwayi

GO - Molecular functioni

  1. 4-hydroxybenzoate decaprenyltransferase activity Source: UniProtKB-EC
  2. 4-hydroxybenzoate nonaprenyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
  2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate polyprenyltransferase, mitochondrial (EC:2.5.1.39)
Alternative name(s):
Para-hydroxybenzoate--polyprenyltransferase
Short name:
PHB:polyprenyltransferase
Gene namesi
Name:COQ2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421Helical; Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Transmembranei149 – 16921Helical; Reviewed prediction
Add
BLAST
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Reviewed prediction
Add
BLAST
Transmembranei301 – 32121Helical; Reviewed prediction
Add
BLAST
Transmembranei333 – 35321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434Mitochondrion Reviewed prediction
Add
BLAST
Chaini35 – 3713374-hydroxybenzoate polyprenyltransferase, mitochondrial
PRO_0000262866Add
BLAST

Proteomic databases

PRIDEiQ2KIQ4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007549.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0382.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ2KIQ4.
KOiK06125.

Family and domain databases

InterProiIPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIQ4-1 [UniParc]FASTAAdd to Basket

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MLGSCGAGLV RGLRAETQAW LWGTRGRSLA LVHAARGLHA ANWQPSPGQG    50
PRGRPLSLSA AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA 100
ADPGCLPDWY MLSLFGTGAV LMRGAGCTIN DMWDRDYDKK VTRTASRPIA 150
AGDISTFRSF VFLGGQLTLA LGVLLCLNYY SIALGAASLL LVTTYPLMKR 200
ITYWPQLALG LTFNWGALLG WSAVKGSCDP SVCLPLYFSG IMWTLIYDTI 250
YAHQDKKDDA LIGLKSTALL FREDTKKWLS GFSVAMLGAL SLVGVNSGQT 300
MPYYTALAAV GAHLAHQIYT LDINRPEDCW EKFTSNRTIG LIIFLGIVLG 350
NLCKAKETDK TRKNIENRME N 371
Length:371
Mass (Da):40,628
Last modified:March 7, 2006 - v1
Checksum:i63617A2E114D06CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112551 mRNA. Translation: AAI12552.1.
RefSeqiNP_001039358.1. NM_001045893.2.
UniGeneiBt.87535.

Genome annotation databases

GeneIDi504633.
KEGGibta:504633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112551 mRNA. Translation: AAI12552.1 .
RefSeqi NP_001039358.1. NM_001045893.2.
UniGenei Bt.87535.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007549.

Proteomic databases

PRIDEi Q2KIQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 504633.
KEGGi bta:504633.

Organism-specific databases

CTDi 27235.

Phylogenomic databases

eggNOGi COG0382.
HOGENOMi HOG000003697.
HOVERGENi HBG081302.
InParanoidi Q2KIQ4.
KOi K06125.

Enzyme and pathway databases

UniPathwayi UPA00232 .

Miscellaneous databases

NextBioi 20866766.

Family and domain databases

InterProi IPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
[Graphical view ]
Pfami PF01040. UbiA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01474. ubiA_proteo. 1 hit.
PROSITEi PS00943. UBIA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiCOQ2_BOVIN
AccessioniPrimary (citable) accession number: Q2KIQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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