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Q2KIQ4

- COQ2_BOVIN

UniProt

Q2KIQ4 - COQ2_BOVIN

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Protein

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene

COQ2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity).By similarity

Catalytic activityi

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.

Pathwayi

GO - Molecular functioni

  1. 4-hydroxybenzoate decaprenyltransferase activity Source: UniProtKB-EC
  2. 4-hydroxybenzoate nonaprenyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
  2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate polyprenyltransferase, mitochondrial (EC:2.5.1.39)
Alternative name(s):
Para-hydroxybenzoate--polyprenyltransferase
Short name:
PHB:polyprenyltransferase
Gene namesi
Name:COQ2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
BLAST
Chaini35 – 3713374-hydroxybenzoate polyprenyltransferase, mitochondrialPRO_0000262866Add
BLAST

Proteomic databases

PRIDEiQ2KIQ4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007549.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0382.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ2KIQ4.
KOiK06125.

Family and domain databases

InterProiIPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGSCGAGLV RGLRAETQAW LWGTRGRSLA LVHAARGLHA ANWQPSPGQG
60 70 80 90 100
PRGRPLSLSA AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA
110 120 130 140 150
ADPGCLPDWY MLSLFGTGAV LMRGAGCTIN DMWDRDYDKK VTRTASRPIA
160 170 180 190 200
AGDISTFRSF VFLGGQLTLA LGVLLCLNYY SIALGAASLL LVTTYPLMKR
210 220 230 240 250
ITYWPQLALG LTFNWGALLG WSAVKGSCDP SVCLPLYFSG IMWTLIYDTI
260 270 280 290 300
YAHQDKKDDA LIGLKSTALL FREDTKKWLS GFSVAMLGAL SLVGVNSGQT
310 320 330 340 350
MPYYTALAAV GAHLAHQIYT LDINRPEDCW EKFTSNRTIG LIIFLGIVLG
360 370
NLCKAKETDK TRKNIENRME N
Length:371
Mass (Da):40,628
Last modified:March 7, 2006 - v1
Checksum:i63617A2E114D06CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112551 mRNA. Translation: AAI12552.1.
RefSeqiNP_001039358.1. NM_001045893.2.
UniGeneiBt.87535.

Genome annotation databases

GeneIDi504633.
KEGGibta:504633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112551 mRNA. Translation: AAI12552.1 .
RefSeqi NP_001039358.1. NM_001045893.2.
UniGenei Bt.87535.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007549.

Proteomic databases

PRIDEi Q2KIQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 504633.
KEGGi bta:504633.

Organism-specific databases

CTDi 27235.

Phylogenomic databases

eggNOGi COG0382.
HOGENOMi HOG000003697.
HOVERGENi HBG081302.
InParanoidi Q2KIQ4.
KOi K06125.

Enzyme and pathway databases

UniPathwayi UPA00232 .

Miscellaneous databases

NextBioi 20866766.

Family and domain databases

InterProi IPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
[Graphical view ]
Pfami PF01040. UbiA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01474. ubiA_proteo. 1 hit.
PROSITEi PS00943. UBIA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiCOQ2_BOVIN
AccessioniPrimary (citable) accession number: Q2KIQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3