Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q2KIQ4

- COQ2_BOVIN

UniProt

Q2KIQ4 - COQ2_BOVIN

Protein

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene

COQ2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB By similarity.By similarity

    Catalytic activityi

    A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.

    Pathwayi

    GO - Molecular functioni

    1. 4-hydroxybenzoate decaprenyltransferase activity Source: UniProtKB-EC
    2. 4-hydroxybenzoate nonaprenyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW
    2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Ubiquinone biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxybenzoate polyprenyltransferase, mitochondrial (EC:2.5.1.39)
    Alternative name(s):
    Para-hydroxybenzoate--polyprenyltransferase
    Short name:
    PHB:polyprenyltransferase
    Gene namesi
    Name:COQ2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
    BLAST
    Chaini35 – 3713374-hydroxybenzoate polyprenyltransferase, mitochondrialPRO_0000262866Add
    BLAST

    Proteomic databases

    PRIDEiQ2KIQ4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000007549.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UbiA prenyltransferase family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0382.
    HOGENOMiHOG000003697.
    HOVERGENiHBG081302.
    InParanoidiQ2KIQ4.
    KOiK06125.

    Family and domain databases

    InterProiIPR006370. HB_polyprenyl-transferase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view]
    PfamiPF01040. UbiA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
    PROSITEiPS00943. UBIA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2KIQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGSCGAGLV RGLRAETQAW LWGTRGRSLA LVHAARGLHA ANWQPSPGQG    50
    PRGRPLSLSA AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA 100
    ADPGCLPDWY MLSLFGTGAV LMRGAGCTIN DMWDRDYDKK VTRTASRPIA 150
    AGDISTFRSF VFLGGQLTLA LGVLLCLNYY SIALGAASLL LVTTYPLMKR 200
    ITYWPQLALG LTFNWGALLG WSAVKGSCDP SVCLPLYFSG IMWTLIYDTI 250
    YAHQDKKDDA LIGLKSTALL FREDTKKWLS GFSVAMLGAL SLVGVNSGQT 300
    MPYYTALAAV GAHLAHQIYT LDINRPEDCW EKFTSNRTIG LIIFLGIVLG 350
    NLCKAKETDK TRKNIENRME N 371
    Length:371
    Mass (Da):40,628
    Last modified:March 7, 2006 - v1
    Checksum:i63617A2E114D06CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112551 mRNA. Translation: AAI12552.1.
    RefSeqiNP_001039358.1. NM_001045893.2.
    UniGeneiBt.87535.

    Genome annotation databases

    GeneIDi504633.
    KEGGibta:504633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112551 mRNA. Translation: AAI12552.1 .
    RefSeqi NP_001039358.1. NM_001045893.2.
    UniGenei Bt.87535.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000007549.

    Proteomic databases

    PRIDEi Q2KIQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 504633.
    KEGGi bta:504633.

    Organism-specific databases

    CTDi 27235.

    Phylogenomic databases

    eggNOGi COG0382.
    HOGENOMi HOG000003697.
    HOVERGENi HBG081302.
    InParanoidi Q2KIQ4.
    KOi K06125.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .

    Miscellaneous databases

    NextBioi 20866766.

    Family and domain databases

    InterProi IPR006370. HB_polyprenyl-transferase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view ]
    Pfami PF01040. UbiA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01474. ubiA_proteo. 1 hit.
    PROSITEi PS00943. UBIA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Testis.

    Entry informationi

    Entry nameiCOQ2_BOVIN
    AccessioniPrimary (citable) accession number: Q2KIQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3