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Q2KIQ4 (COQ2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxybenzoate polyprenyltransferase, mitochondrial
EC=2.5.1.39
Alternative name(s):
Para-hydroxybenzoate--polyprenyltransferase
Short name=PHB:polyprenyltransferase
Gene names
Name:COQ2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB By similarity.

Catalytic activity

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the UbiA prenyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3434Mitochondrion Potential
Chain35 – 3713374-hydroxybenzoate polyprenyltransferase, mitochondrial
PRO_0000262866

Regions

Transmembrane84 – 10421Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane301 – 32121Helical; Potential
Transmembrane333 – 35321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2KIQ4 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 63617A2E114D06CE

FASTA37140,628
        10         20         30         40         50         60 
MLGSCGAGLV RGLRAETQAW LWGTRGRSLA LVHAARGLHA ANWQPSPGQG PRGRPLSLSA 

        70         80         90        100        110        120 
AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA ADPGCLPDWY MLSLFGTGAV 

       130        140        150        160        170        180 
LMRGAGCTIN DMWDRDYDKK VTRTASRPIA AGDISTFRSF VFLGGQLTLA LGVLLCLNYY 

       190        200        210        220        230        240 
SIALGAASLL LVTTYPLMKR ITYWPQLALG LTFNWGALLG WSAVKGSCDP SVCLPLYFSG 

       250        260        270        280        290        300 
IMWTLIYDTI YAHQDKKDDA LIGLKSTALL FREDTKKWLS GFSVAMLGAL SLVGVNSGQT 

       310        320        330        340        350        360 
MPYYTALAAV GAHLAHQIYT LDINRPEDCW EKFTSNRTIG LIIFLGIVLG NLCKAKETDK 

       370 
TRKNIENRME N

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC112551 mRNA. Translation: AAI12552.1.
IPIIPI00692976.
RefSeqNP_001039358.1. NM_001045893.2.
UniGeneBt.87535.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000007549.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID504633.
KEGGbta:504633.

Organism-specific databases

CTD27235.

Phylogenomic databases

eggNOGCOG0382.
HOGENOMHOG000003697.
HOVERGENHBG081302.
InParanoidQ2KIQ4.
KOK06125.
OrthoDBEOG4CC421.

Enzyme and pathway databases

UniPathwayUPA00232.

Family and domain databases

InterProIPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01474. ubiA_proteo. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866766.

Entry information

Entry nameCOQ2_BOVIN
AccessionPrimary (citable) accession number: Q2KIQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 7, 2006
Last modified: April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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