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Protein

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene

COQ2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.UniRule annotation

Catalytic activityi

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotation (EC:2.5.1.39UniRule annotation)
Short name:
4-HB polyprenyltransferaseUniRule annotation
Alternative name(s):
Para-hydroxybenzoate--polyprenyltransferaseUniRule annotation
Short name:
PHB:PPTUniRule annotation
Short name:
PHB:polyprenyltransferaseUniRule annotation
Gene namesi
Name:COQ2UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Matrix side UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei172 – 19221HelicalUniRule annotationAdd
BLAST
Transmembranei201 – 22121HelicalUniRule annotationAdd
BLAST
Transmembranei232 – 25221HelicalUniRule annotationAdd
BLAST
Transmembranei278 – 29821HelicalUniRule annotationAdd
BLAST
Transmembranei301 – 32121HelicalUniRule annotationAdd
BLAST
Transmembranei333 – 35321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
BLAST
Chaini35 – 3713374-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotationPRO_0000262866Add
BLAST

Proteomic databases

PRIDEiQ2KIQ4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007549.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 14423Allylic polyprenyl diphosphate-binding siteUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.UniRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0382.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ2KIQ4.
KOiK06125.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSCGAGLV RGLRAETQAW LWGTRGRSLA LVHAARGLHA ANWQPSPGQG
60 70 80 90 100
PRGRPLSLSA AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA
110 120 130 140 150
ADPGCLPDWY MLSLFGTGAV LMRGAGCTIN DMWDRDYDKK VTRTASRPIA
160 170 180 190 200
AGDISTFRSF VFLGGQLTLA LGVLLCLNYY SIALGAASLL LVTTYPLMKR
210 220 230 240 250
ITYWPQLALG LTFNWGALLG WSAVKGSCDP SVCLPLYFSG IMWTLIYDTI
260 270 280 290 300
YAHQDKKDDA LIGLKSTALL FREDTKKWLS GFSVAMLGAL SLVGVNSGQT
310 320 330 340 350
MPYYTALAAV GAHLAHQIYT LDINRPEDCW EKFTSNRTIG LIIFLGIVLG
360 370
NLCKAKETDK TRKNIENRME N
Length:371
Mass (Da):40,628
Last modified:March 7, 2006 - v1
Checksum:i63617A2E114D06CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112551 mRNA. Translation: AAI12552.1.
RefSeqiNP_001039358.1. NM_001045893.2.
UniGeneiBt.87535.

Genome annotation databases

GeneIDi504633.
KEGGibta:504633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112551 mRNA. Translation: AAI12552.1.
RefSeqiNP_001039358.1. NM_001045893.2.
UniGeneiBt.87535.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007549.

Proteomic databases

PRIDEiQ2KIQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504633.
KEGGibta:504633.

Organism-specific databases

CTDi27235.

Phylogenomic databases

eggNOGiCOG0382.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ2KIQ4.
KOiK06125.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

NextBioi20866766.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiCOQ2_BOVIN
AccessioniPrimary (citable) accession number: Q2KIQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 7, 2006
Last modified: May 27, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.