Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kappa-type opioid receptor

Gene

OPRK1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-type opioid receptor
Short name:
K-OR-1
Short name:
KOR-1
Gene namesi
Name:OPRK1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularBy similarityAdd
BLAST
Transmembranei58 – 8528Helical; Name=1By similarityAdd
BLAST
Topological domaini86 – 9510CytoplasmicBy similarity
Transmembranei96 – 11924Helical; Name=2By similarityAdd
BLAST
Topological domaini120 – 13213ExtracellularBy similarityAdd
BLAST
Transmembranei133 – 15422Helical; Name=3By similarityAdd
BLAST
Topological domaini155 – 17319CytoplasmicBy similarityAdd
BLAST
Transmembranei174 – 19623Helical; Name=4By similarityAdd
BLAST
Topological domaini197 – 22226ExtracellularBy similarityAdd
BLAST
Transmembranei223 – 24725Helical; Name=5By similarityAdd
BLAST
Topological domaini248 – 27427CytoplasmicBy similarityAdd
BLAST
Transmembranei275 – 29622Helical; Name=6By similarityAdd
BLAST
Topological domaini297 – 31115ExtracellularBy similarityAdd
BLAST
Transmembranei312 – 33322Helical; Name=7By similarityAdd
BLAST
Topological domaini334 – 38047CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Kappa-type opioid receptorPRO_0000244881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)By similarity
Glycosylationi39 – 391N-linked (GlcNAc...)By similarity
Disulfide bondi131 ↔ 210PROSITE-ProRule annotation
Modified residuei157 – 1571PhosphotyrosineBy similarity
Lipidationi345 – 3451S-palmitoyl cysteineSequence analysis
Modified residuei363 – 3631PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ2KIP6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000914.

Interactioni

Subunit structurei

Interacts with SLC9A3R1. Interacts with GABARAPL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001209.

Chemistry

BindingDBiQ2KIP6.

Structurei

3D structure databases

ProteinModelPortaliQ2KIP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiQ2KIP6.
KOiK04214.
OMAiPFQSTEY.
OrthoDBiEOG091G0HEN.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000452. Kappa_opi_rcpt.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00532. KAPPAOPIOIDR.
PR00384. OPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPVQIFRG EPGPTCSPST CLPPNGSGWF PGWAEPDGNG SAGSEDVLLE
60 70 80 90 100
PAHISPVILV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN
110 120 130 140 150
LALADALVTT TMPFQSTVYL MNSWPFGDVL CKVVISIDYY NMFTSIFTLT
160 170 180 190 200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWILSSSVG ISAIVLGGTK
210 220 230 240 250
VREDMEVIEC SLQFPDDDYS WWDLFMKVCV FVFAFVIPVL IIIVCYTLMI
260 270 280 290 300
LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG
310 320 330 340 350
STAHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPIKM
360 370 380
RMERQSTSRV RNTVQDPAYV REVDGVNKPV
Length:380
Mass (Da):42,626
Last modified:March 7, 2006 - v1
Checksum:i22F2F39B9E47A87C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112561 mRNA. Translation: AAI12562.1.
RefSeqiNP_001039945.1. NM_001046480.3.
NP_001305693.1. NM_001318764.1.
UniGeneiBt.59519.

Genome annotation databases

EnsembliENSBTAT00000001209; ENSBTAP00000001209; ENSBTAG00000000914.
GeneIDi540519.
KEGGibta:540519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112561 mRNA. Translation: AAI12562.1.
RefSeqiNP_001039945.1. NM_001046480.3.
NP_001305693.1. NM_001318764.1.
UniGeneiBt.59519.

3D structure databases

ProteinModelPortaliQ2KIP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001209.

Chemistry

BindingDBiQ2KIP6.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ2KIP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001209; ENSBTAP00000001209; ENSBTAG00000000914.
GeneIDi540519.
KEGGibta:540519.

Organism-specific databases

CTDi4986.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiQ2KIP6.
KOiK04214.
OMAiPFQSTEY.
OrthoDBiEOG091G0HEN.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSBTAG00000000914.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000452. Kappa_opi_rcpt.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00532. KAPPAOPIOIDR.
PR00384. OPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPRK_BOVIN
AccessioniPrimary (citable) accession number: Q2KIP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.