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Protein

Porphobilinogen deaminase

Gene

HMBS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.By similarity

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.By similarity

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.

Cofactori

dipyrromethaneNote: Binds 1 dipyrromethane group covalently.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (ALAD)
  2. Porphobilinogen deaminase (HMBS)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (UROD)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-189451 Heme biosynthesis
UniPathwayiUPA00251; UER00319

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminase (EC:2.5.1.61)
Alternative name(s):
Hydroxymethylbilane synthase
Short name:
HMBS
Gene namesi
Name:HMBS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:29870 HMBS

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002444052 – 361Porphobilinogen deaminaseAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei74N6-acetyllysineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei261S-(dipyrrolylmethanemethyl)cysteineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KIN5
PRIDEiQ2KIN5

Expressioni

Gene expression databases

BgeeiENSBTAG00000005364

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007052

Structurei

3D structure databases

ProteinModelPortaliQ2KIN5
SMRiQ2KIN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.Curated

Phylogenomic databases

eggNOGiKOG2892 Eukaryota
COG0181 LUCA
GeneTreeiENSGT00390000009083
HOGENOMiHOG000228587
HOVERGENiHBG000967
InParanoidiQ2KIN5
KOiK01749
OMAiCQVPIGV
OrthoDBiEOG091G0B9U
TreeFamiTF105389

Family and domain databases

Gene3Di3.30.160.40, 1 hit
HAMAPiMF_00260 Porphobil_deam, 1 hit
InterProiView protein in InterPro
IPR000860 HemC
IPR022419 Porphobilin_deaminase_cofac_BS
IPR022417 Porphobilin_deaminase_N
IPR022418 Porphobilinogen_deaminase_C
IPR036803 Porphobilinogen_deaminase_C_sf
PANTHERiPTHR11557 PTHR11557, 1 hit
PfamiView protein in Pfam
PF01379 Porphobil_deam, 1 hit
PF03900 Porphobil_deamC, 1 hit
PIRSFiPIRSF001438 4pyrrol_synth_OHMeBilane_synth, 1 hit
PRINTSiPR00151 PORPHBDMNASE
SUPFAMiSSF54782 SSF54782, 2 hits
TIGRFAMsiTIGR00212 hemC, 1 hit
PROSITEiView protein in PROSITE
PS00533 PORPHOBILINOGEN_DEAM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNGNAAAI AEEDTPKMRV IRVGTRKSQL ARIQTDSVVA TLKALYPGLQ
60 70 80 90 100
FEIIAMSTTG DKILDTALSK IGEKSLFTKE LEHALERNEV DLVVHSLKDL
110 120 130 140 150
PTVLPPGFTI GAVCKRESPY DAVVFHPKFV GKTLETLPEK SVVGTSSLRR
160 170 180 190 200
AAQLQRKFPH LEFKSIRGNL NTRLRKLDEL QEFSAIILAT AGLQRMGWQN
210 220 230 240 250
RVGQILHPEE CMYAVGQGAL GVEVRAKDQD ILDLVGVLHD PETLLRCIAE
260 270 280 290 300
RSFLRHLEGG CSVPVAVHTA IKDGQLYLTG GVWSLNGAET MQDTMQTTIH
310 320 330 340 350
VPVQHEDGPE DDPQLVGITA RNIPRQPQLA AENLGISLAT LLLNKGAKNI
360
LDVARQLNEA H
Length:361
Mass (Da):39,515
Last modified:March 7, 2006 - v1
Checksum:i15596E68C92E80C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112573 mRNA Translation: AAI12574.1
RefSeqiNP_001039672.1, NM_001046207.1
UniGeneiBt.21218

Genome annotation databases

EnsembliENSBTAT00000007052; ENSBTAP00000007052; ENSBTAG00000005364
GeneIDi515614
KEGGibta:515614

Similar proteinsi

Entry informationi

Entry nameiHEM3_BOVIN
AccessioniPrimary (citable) accession number: Q2KIN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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