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Q2KIM0 (FUCO_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tissue alpha-L-fucosidase

EC=3.2.1.51
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name=Alpha-L-fucosidase 1
Gene names
Name:FUCA1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins By similarity.

Catalytic activity

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Subunit structure

Homotetramer By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfucose metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionalpha-L-fucosidase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

fucose binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 468446Tissue alpha-L-fucosidase
PRO_0000281855

Sites

Site2991May be important for catalysis By similarity

Amino acid modifications

Modified residue1731Phosphothreonine By similarity
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation3201N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2KIM0 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: E01841FC016A9E38

FASTA46854,089
        10         20         30         40         50         60 
MRSWVVGARL LLLLQLVLVL GAVRLPPCTD PRHCTDPPRY TPDWPSLDSR PLPAWFDEAK 

        70         80         90        100        110        120 
FGVFVHWGVF SVPAWGSEWF WWHWQGEKLP QYESFMKENY PPDFSYADFG PRFTARFFNP 

       130        140        150        160        170        180 
DSWADLFKAA GAKYVVLTTK HHEGYTNWPS PVSWNWNSKD VGPHRDLVGE LGTAIRKRNI 

       190        200        210        220        230        240 
RYGLYHSLLE WFHPLYLRDK KNGFKTQYFV NAKTMPELYD LVNRYKPDLI WSDGEWECPD 

       250        260        270        280        290        300 
TYWNSTDFLA WLYNDSPVKD EVVVNDRWGQ NCSCHHGGYY NCKDKFQPET LPDHKWEMCT 

       310        320        330        340        350        360 
SIDQRSWGYR RDMEMADITN ESTIISELVQ TVSLGGNYLL NVGPTKDGLI VPIFQERLLA 

       370        380        390        400        410        420 
VGKWLSINGE AIYASKPWRV QSEKNSVWYT SKGLAVYAIL LHWPEYGILS LISPIATSTT 

       430        440        450        460 
KVTMLGIQKD LKWSLNPSGK GLLVFLPQLP PAALPTEFAW TIKLTGVK 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC112588 mRNA. Translation: AAI12589.1.
RefSeqNP_001039500.1. NM_001046035.2.
UniGeneBt.2169.

3D structure databases

ProteinModelPortalQ2KIM0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000040572.

Chemistry

BindingDBQ2KIM0.
ChEMBLCHEMBL3545.

Protein family/group databases

CAZyGH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbQ2KIM0.
PRIDEQ2KIM0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000042970; ENSBTAP00000040572; ENSBTAG00000030434.
GeneID509522.
KEGGbta:509522.

Organism-specific databases

CTD2517.

Phylogenomic databases

eggNOGCOG3669.
GeneTreeENSGT00440000035378.
HOGENOMHOG000029598.
HOVERGENHBG002155.
InParanoidQ2KIM0.
KOK01206.
OMANGFKTQH.
OrthoDBEOG7DC249.
TreeFamTF313034.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProIPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
PfamPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSPR00741. GLHYDRLASE29.
SMARTSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20869005.

Entry information

Entry nameFUCO_BOVIN
AccessionPrimary (citable) accession number: Q2KIM0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 7, 2006
Last modified: March 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries