Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tissue alpha-L-fucosidase

Gene

FUCA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei299 – 2991May be important for catalysisPROSITE-ProRule annotation

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: GO_Central
  2. fucose binding Source: GO_Central

GO - Biological processi

  1. fucose metabolic process Source: InterPro
  2. glycoside catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
Gene namesi
Name:FUCA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 2

Subcellular locationi

  1. Lysosome By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. lysosome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 468446Tissue alpha-L-fucosidasePRO_0000281855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731PhosphothreonineBy similarity
Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2KIM0.
PRIDEiQ2KIM0.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040572.

Structurei

3D structure databases

ProteinModelPortaliQ2KIM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiQ2KIM0.
KOiK01206.
OMAiNGFKTQH.
OrthoDBiEOG7DC249.
TreeFamiTF313034.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSWVVGARL LLLLQLVLVL GAVRLPPCTD PRHCTDPPRY TPDWPSLDSR
60 70 80 90 100
PLPAWFDEAK FGVFVHWGVF SVPAWGSEWF WWHWQGEKLP QYESFMKENY
110 120 130 140 150
PPDFSYADFG PRFTARFFNP DSWADLFKAA GAKYVVLTTK HHEGYTNWPS
160 170 180 190 200
PVSWNWNSKD VGPHRDLVGE LGTAIRKRNI RYGLYHSLLE WFHPLYLRDK
210 220 230 240 250
KNGFKTQYFV NAKTMPELYD LVNRYKPDLI WSDGEWECPD TYWNSTDFLA
260 270 280 290 300
WLYNDSPVKD EVVVNDRWGQ NCSCHHGGYY NCKDKFQPET LPDHKWEMCT
310 320 330 340 350
SIDQRSWGYR RDMEMADITN ESTIISELVQ TVSLGGNYLL NVGPTKDGLI
360 370 380 390 400
VPIFQERLLA VGKWLSINGE AIYASKPWRV QSEKNSVWYT SKGLAVYAIL
410 420 430 440 450
LHWPEYGILS LISPIATSTT KVTMLGIQKD LKWSLNPSGK GLLVFLPQLP
460
PAALPTEFAW TIKLTGVK
Length:468
Mass (Da):54,089
Last modified:March 7, 2006 - v1
Checksum:iE01841FC016A9E38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112588 mRNA. Translation: AAI12589.1.
RefSeqiNP_001039500.1. NM_001046035.2.
UniGeneiBt.2169.

Genome annotation databases

EnsembliENSBTAT00000042970; ENSBTAP00000040572; ENSBTAG00000030434.
GeneIDi509522.
KEGGibta:509522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112588 mRNA. Translation: AAI12589.1.
RefSeqiNP_001039500.1. NM_001046035.2.
UniGeneiBt.2169.

3D structure databases

ProteinModelPortaliQ2KIM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040572.

Chemistry

BindingDBiQ2KIM0.
ChEMBLiCHEMBL3545.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbiQ2KIM0.
PRIDEiQ2KIM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000042970; ENSBTAP00000040572; ENSBTAG00000030434.
GeneIDi509522.
KEGGibta:509522.

Organism-specific databases

CTDi2517.

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiQ2KIM0.
KOiK01206.
OMAiNGFKTQH.
OrthoDBiEOG7DC249.
TreeFamiTF313034.

Miscellaneous databases

NextBioi20869005.
PROiQ2KIM0.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiFUCO_BOVIN
AccessioniPrimary (citable) accession number: Q2KIM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 7, 2006
Last modified: April 29, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.