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Q2KIM0

- FUCO_BOVIN

UniProt

Q2KIM0 - FUCO_BOVIN

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Protein

Tissue alpha-L-fucosidase

Gene
FUCA1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins By similarity.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei299 – 2991May be important for catalysis By similarity

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: RefGenome
  2. fucose binding Source: RefGenome

GO - Biological processi

  1. fucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
Gene namesi
Name:FUCA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 468446Tissue alpha-L-fucosidasePRO_0000281855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731Phosphothreonine By similarity
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2KIM0.
PRIDEiQ2KIM0.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040572.

Structurei

3D structure databases

ProteinModelPortaliQ2KIM0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiQ2KIM0.
KOiK01206.
OMAiIFLHWPD.
OrthoDBiEOG7DC249.
TreeFamiTF313034.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIM0-1 [UniParc]FASTAAdd to Basket

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MRSWVVGARL LLLLQLVLVL GAVRLPPCTD PRHCTDPPRY TPDWPSLDSR    50
PLPAWFDEAK FGVFVHWGVF SVPAWGSEWF WWHWQGEKLP QYESFMKENY 100
PPDFSYADFG PRFTARFFNP DSWADLFKAA GAKYVVLTTK HHEGYTNWPS 150
PVSWNWNSKD VGPHRDLVGE LGTAIRKRNI RYGLYHSLLE WFHPLYLRDK 200
KNGFKTQYFV NAKTMPELYD LVNRYKPDLI WSDGEWECPD TYWNSTDFLA 250
WLYNDSPVKD EVVVNDRWGQ NCSCHHGGYY NCKDKFQPET LPDHKWEMCT 300
SIDQRSWGYR RDMEMADITN ESTIISELVQ TVSLGGNYLL NVGPTKDGLI 350
VPIFQERLLA VGKWLSINGE AIYASKPWRV QSEKNSVWYT SKGLAVYAIL 400
LHWPEYGILS LISPIATSTT KVTMLGIQKD LKWSLNPSGK GLLVFLPQLP 450
PAALPTEFAW TIKLTGVK 468
Length:468
Mass (Da):54,089
Last modified:March 7, 2006 - v1
Checksum:iE01841FC016A9E38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112588 mRNA. Translation: AAI12589.1.
RefSeqiNP_001039500.1. NM_001046035.2.
UniGeneiBt.2169.

Genome annotation databases

EnsembliENSBTAT00000042970; ENSBTAP00000040572; ENSBTAG00000030434.
GeneIDi509522.
KEGGibta:509522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112588 mRNA. Translation: AAI12589.1 .
RefSeqi NP_001039500.1. NM_001046035.2.
UniGenei Bt.2169.

3D structure databases

ProteinModelPortali Q2KIM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000040572.

Chemistry

BindingDBi Q2KIM0.
ChEMBLi CHEMBL3545.

Protein family/group databases

CAZyi GH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbi Q2KIM0.
PRIDEi Q2KIM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000042970 ; ENSBTAP00000040572 ; ENSBTAG00000030434 .
GeneIDi 509522.
KEGGi bta:509522.

Organism-specific databases

CTDi 2517.

Phylogenomic databases

eggNOGi COG3669.
GeneTreei ENSGT00440000035378.
HOGENOMi HOG000029598.
HOVERGENi HBG002155.
InParanoidi Q2KIM0.
KOi K01206.
OMAi IFLHWPD.
OrthoDBi EOG7DC249.
TreeFami TF313034.

Miscellaneous databases

NextBioi 20869005.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiFUCO_BOVIN
AccessioniPrimary (citable) accession number: Q2KIM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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