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Protein

Tissue alpha-L-fucosidase

Gene

FUCA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei299May be important for catalysisPROSITE-ProRule annotation1

GO - Molecular functioni

  • alpha-L-fucosidase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-BTA-6798695 Neutrophil degranulation
R-BTA-975578 Reactions specific to the complex N-glycan synthesis pathway

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
Gene namesi
Name:FUCA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:29140 FUCA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3545

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000028185523 – 468Tissue alpha-L-fucosidaseAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphothreonineBy similarity1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2KIM0
PeptideAtlasiQ2KIM0
PRIDEiQ2KIM0

Expressioni

Gene expression databases

BgeeiENSBTAG00000030434

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040572

Chemistry databases

BindingDBiQ2KIM0

Structurei

3D structure databases

ProteinModelPortaliQ2KIM0
SMRiQ2KIM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
GeneTreeiENSGT00440000035378
HOGENOMiHOG000029598
HOVERGENiHBG002155
InParanoidiQ2KIM0
KOiK01206
OMAiCLIGNNH
OrthoDBiEOG091G085V
TreeFamiTF313034

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR028755 FUCA1
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PTHR10030:SF2 PTHR10030:SF2, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSWVVGARL LLLLQLVLVL GAVRLPPCTD PRHCTDPPRY TPDWPSLDSR
60 70 80 90 100
PLPAWFDEAK FGVFVHWGVF SVPAWGSEWF WWHWQGEKLP QYESFMKENY
110 120 130 140 150
PPDFSYADFG PRFTARFFNP DSWADLFKAA GAKYVVLTTK HHEGYTNWPS
160 170 180 190 200
PVSWNWNSKD VGPHRDLVGE LGTAIRKRNI RYGLYHSLLE WFHPLYLRDK
210 220 230 240 250
KNGFKTQYFV NAKTMPELYD LVNRYKPDLI WSDGEWECPD TYWNSTDFLA
260 270 280 290 300
WLYNDSPVKD EVVVNDRWGQ NCSCHHGGYY NCKDKFQPET LPDHKWEMCT
310 320 330 340 350
SIDQRSWGYR RDMEMADITN ESTIISELVQ TVSLGGNYLL NVGPTKDGLI
360 370 380 390 400
VPIFQERLLA VGKWLSINGE AIYASKPWRV QSEKNSVWYT SKGLAVYAIL
410 420 430 440 450
LHWPEYGILS LISPIATSTT KVTMLGIQKD LKWSLNPSGK GLLVFLPQLP
460
PAALPTEFAW TIKLTGVK
Length:468
Mass (Da):54,089
Last modified:March 7, 2006 - v1
Checksum:iE01841FC016A9E38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112588 mRNA Translation: AAI12589.1
RefSeqiNP_001039500.1, NM_001046035.2
UniGeneiBt.2169

Genome annotation databases

EnsembliENSBTAT00000042970; ENSBTAP00000040572; ENSBTAG00000030434
GeneIDi509522
KEGGibta:509522

Similar proteinsi

Entry informationi

Entry nameiFUCO_BOVIN
AccessioniPrimary (citable) accession number: Q2KIM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health