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Q2KIL5

- PDIA5_BOVIN

UniProt

Q2KIL5 - PDIA5_BOVIN

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Protein

Protein disulfide-isomerase A5

Gene
PDIA5
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: RefGenome

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: RefGenome
  3. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_211201. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A5 (EC:5.3.4.1)
Gene namesi
Name:PDIA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 521496Protein disulfide-isomerase A5PRO_0000244882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi184 ↔ 187Redox-active By similarity
Disulfide bondi307 ↔ 310Redox-active By similarity
Disulfide bondi428 ↔ 431Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ2KIL5.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025128.

Structurei

3D structure databases

ProteinModelPortaliQ2KIL5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 263128Thioredoxin 1Add
BLAST
Domaini274 – 386113Thioredoxin 2Add
BLAST
Domaini387 – 508122Thioredoxin 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi518 – 5214Prevents secretion from ER Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi387 – 3926Poly-Pro

Sequence similaritiesi

Contains 3 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00730000110455.
HOGENOMiHOG000039967.
HOVERGENiHBG053547.
InParanoidiQ2KIL5.
KOiK09583.
OMAiYYHYGKF.
OrthoDBiEOG74TWZ6.
TreeFamiTF106379.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIL5-1 [UniParc]FASTAAdd to Basket

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MARVVPAWLL LPLAVWVVLP TWLSSAKFSS LIERISDPKD LKKLLRTRNN    50
VLVLYSKSEA AAESHLKLLS TVAQAVKGQG TICWVDCGDA ESRKLCKKMK 100
VDLSAKDKKV ELFHYQDGAF HTEYNRAVTF KSIVAFLKDP KGPPLWEEDP 150
GAKDVVHIDN EKDFRRLLKK EEKPILMMFY APWCSVCKRI MPHFQKAATQ 200
LRGQFVLAGM NVYPSEFENI KEEYSVRGYP TICYFEKGRF LFQYDSYGST 250
AEDIVEWLKN PQPPQPQVPE TPWADEGGSV YHLSDEDFDQ FVKEHSSVLV 300
MFHAPWCGHC KKMKPEFESA AEVLHGEGDS SGVLAAVDAT VNKALAERFH 350
IAEFPTLKYF KNGEKYAVPA LRTKKSFIEW MRNPESPPPP DPAWEEQQTS 400
VLHLSGDNFR ETLKRKKHAL VMFYAPWCPH CKKAIPHFTA AADAFKDDRK 450
IACAAIDCVK ENNKDLCQQE AVKAYPTFHY YHYGKFVEKY DTNPTELGFT 500
SFIRTLREGD HERLGKKKEE L 521
Length:521
Mass (Da):59,673
Last modified:March 7, 2006 - v1
Checksum:iA05A85EB4EEA2BEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112593 mRNA. Translation: AAI12594.1.
RefSeqiNP_001039556.1. NM_001046091.2.
UniGeneiBt.6804.

Genome annotation databases

EnsembliENSBTAT00000025128; ENSBTAP00000025128; ENSBTAG00000018877.
GeneIDi511603.
KEGGibta:511603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112593 mRNA. Translation: AAI12594.1 .
RefSeqi NP_001039556.1. NM_001046091.2.
UniGenei Bt.6804.

3D structure databases

ProteinModelPortali Q2KIL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000025128.

Proteomic databases

PRIDEi Q2KIL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000025128 ; ENSBTAP00000025128 ; ENSBTAG00000018877 .
GeneIDi 511603.
KEGGi bta:511603.

Organism-specific databases

CTDi 10954.

Phylogenomic databases

eggNOGi COG0526.
GeneTreei ENSGT00730000110455.
HOGENOMi HOG000039967.
HOVERGENi HBG053547.
InParanoidi Q2KIL5.
KOi K09583.
OMAi YYHYGKF.
OrthoDBi EOG74TWZ6.
TreeFami TF106379.

Enzyme and pathway databases

Reactomei REACT_211201. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 20870009.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 3 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiPDIA5_BOVIN
AccessioniPrimary (citable) accession number: Q2KIL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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