Reviewed, UniProtKB/Swiss-Prot Q2KIL5 (PDIA5_BOVIN)

Names and origin

Protein names

Recommended name:
    Protein disulfide-isomerase A5
    EC=5.3.4.1

Gene names

Name:

PDIA5

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Catalyzes the rearrangement of -S-S- bonds in proteins.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the protein disulfide isomerase family. Contains 3 thioredoxin domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Redox-active center Repeat Signal
Molecular function	Isomerase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 521	496	Protein disulfide-isomerase A5		PRO_0000244882
Regions
	Domain	136 – 263	128	Thioredoxin 1
	Domain	274 – 386	113	Thioredoxin 2
	Domain	387 – 508	122	Thioredoxin 3
	Motif	518 – 521	4	Prevents secretion from ER Potential
	Compositional bias	387 – 392	6	Poly-Pro
Amino acid modifications
	Disulfide bond	184 ↔ 187		Redox-active By similarity
	Disulfide bond	307 ↔ 310		Redox-active By similarity
	Disulfide bond	428 ↔ 431		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KIL5-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: A05A85EB4EEA2BEA	FASTA	521	59,673
	10 20 30 40 50 60 MARVVPAWLL LPLAVWVVLP TWLSSAKFSS LIERISDPKD LKKLLRTRNN VLVLYSKSEA 70 80 90 100 110 120 AAESHLKLLS TVAQAVKGQG TICWVDCGDA ESRKLCKKMK VDLSAKDKKV ELFHYQDGAF 130 140 150 160 170 180 HTEYNRAVTF KSIVAFLKDP KGPPLWEEDP GAKDVVHIDN EKDFRRLLKK EEKPILMMFY 190 200 210 220 230 240 APWCSVCKRI MPHFQKAATQ LRGQFVLAGM NVYPSEFENI KEEYSVRGYP TICYFEKGRF 250 260 270 280 290 300 LFQYDSYGST AEDIVEWLKN PQPPQPQVPE TPWADEGGSV YHLSDEDFDQ FVKEHSSVLV 310 320 330 340 350 360 MFHAPWCGHC KKMKPEFESA AEVLHGEGDS SGVLAAVDAT VNKALAERFH IAEFPTLKYF 370 380 390 400 410 420 KNGEKYAVPA LRTKKSFIEW MRNPESPPPP DPAWEEQQTS VLHLSGDNFR ETLKRKKHAL 430 440 450 460 470 480 VMFYAPWCPH CKKAIPHFTA AADAFKDDRK IACAAIDCVK ENNKDLCQQE AVKAYPTFHY 490 500 510 520 YHYGKFVEKY DTNPTELGFT SFIRTLREGD HERLGKKKEE L

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC112593 mRNA. Translation: AAI12594.1.
IPI	IPI00717336.
RefSeq	NP_001039556.1.
UniGene	Bt.6804
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000018877. Bos taurus. [Contig view]
GeneID	511603.
KEGG	bta:511603.
Phylogenomic databases
HOVERGEN	Q2KIL5.
OMA	Q2KIL5. KNPQPPQ.
Enzyme and pathway databases
BRENDA	5.3.4.1. 251.
Family and domain databases
InterPro	IPR000886. ER_targeting_sequence. IPR017936. Thioredoxin-like. IPR006662. Thioredoxin-like_subdom. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 3 hits.
Pfam	PF00085. Thioredoxin. 3 hits. [Graphical view]
PRINTS	PR00421. THIOREDOXIN.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDIA5_BOVIN

Accession

Primary (citable) accession number: Q2KIL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)