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Protein

Protein disulfide-isomerase A5

Gene

PDIA5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A5 (EC:5.3.4.1)
Gene namesi
Name:PDIA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:32699 PDIA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000024488226 – 521Protein disulfide-isomerase A5Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi184 ↔ 187Redox-activePROSITE-ProRule annotation
Disulfide bondi307 ↔ 310Redox-activePROSITE-ProRule annotation
Disulfide bondi428 ↔ 431Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ2KIL5
PRIDEiQ2KIL5

Expressioni

Gene expression databases

BgeeiENSBTAG00000018877

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025128

Structurei

3D structure databases

ProteinModelPortaliQ2KIL5
SMRiQ2KIL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 263Thioredoxin 1PROSITE-ProRule annotationAdd BLAST128
Domaini274 – 386Thioredoxin 2PROSITE-ProRule annotationAdd BLAST113
Domaini387 – 508Thioredoxin 3PROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi518 – 521Prevents secretion from ERPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi387 – 392Poly-Pro6

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133723
HOGENOMiHOG000039967
HOVERGENiHBG053547
InParanoidiQ2KIL5
KOiK09583
OMAiTICYFEK
OrthoDBiEOG091G04ZS
TreeFamiTF106379

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVVPAWLL LPLAVWVVLP TWLSSAKFSS LIERISDPKD LKKLLRTRNN
60 70 80 90 100
VLVLYSKSEA AAESHLKLLS TVAQAVKGQG TICWVDCGDA ESRKLCKKMK
110 120 130 140 150
VDLSAKDKKV ELFHYQDGAF HTEYNRAVTF KSIVAFLKDP KGPPLWEEDP
160 170 180 190 200
GAKDVVHIDN EKDFRRLLKK EEKPILMMFY APWCSVCKRI MPHFQKAATQ
210 220 230 240 250
LRGQFVLAGM NVYPSEFENI KEEYSVRGYP TICYFEKGRF LFQYDSYGST
260 270 280 290 300
AEDIVEWLKN PQPPQPQVPE TPWADEGGSV YHLSDEDFDQ FVKEHSSVLV
310 320 330 340 350
MFHAPWCGHC KKMKPEFESA AEVLHGEGDS SGVLAAVDAT VNKALAERFH
360 370 380 390 400
IAEFPTLKYF KNGEKYAVPA LRTKKSFIEW MRNPESPPPP DPAWEEQQTS
410 420 430 440 450
VLHLSGDNFR ETLKRKKHAL VMFYAPWCPH CKKAIPHFTA AADAFKDDRK
460 470 480 490 500
IACAAIDCVK ENNKDLCQQE AVKAYPTFHY YHYGKFVEKY DTNPTELGFT
510 520
SFIRTLREGD HERLGKKKEE L
Length:521
Mass (Da):59,673
Last modified:March 7, 2006 - v1
Checksum:iA05A85EB4EEA2BEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112593 mRNA Translation: AAI12594.1
RefSeqiNP_001039556.1, NM_001046091.2
UniGeneiBt.6804

Genome annotation databases

EnsembliENSBTAT00000025128; ENSBTAP00000025128; ENSBTAG00000018877
GeneIDi511603
KEGGibta:511603

Similar proteinsi

Entry informationi

Entry nameiPDIA5_BOVIN
AccessioniPrimary (citable) accession number: Q2KIL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health