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Q2KIL5

- PDIA5_BOVIN

UniProt

Q2KIL5 - PDIA5_BOVIN

Protein

Protein disulfide-isomerase A5

Gene

PDIA5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: RefGenome
    3. response to endoplasmic reticulum stress Source: RefGenome

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    ReactomeiREACT_211201. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase A5 (EC:5.3.4.1)
    Gene namesi
    Name:PDIA5
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 1

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 521496Protein disulfide-isomerase A5PRO_0000244882Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi184 ↔ 187Redox-activePROSITE-ProRule annotation
    Disulfide bondi307 ↔ 310Redox-activePROSITE-ProRule annotation
    Disulfide bondi428 ↔ 431Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ2KIL5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000025128.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KIL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 263128Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini274 – 386113Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini387 – 508122Thioredoxin 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi518 – 5214Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi387 – 3926Poly-Pro

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 3 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00730000110455.
    HOGENOMiHOG000039967.
    HOVERGENiHBG053547.
    InParanoidiQ2KIL5.
    KOiK09583.
    OMAiYYHYGKF.
    OrthoDBiEOG74TWZ6.
    TreeFamiTF106379.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 3 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2KIL5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARVVPAWLL LPLAVWVVLP TWLSSAKFSS LIERISDPKD LKKLLRTRNN    50
    VLVLYSKSEA AAESHLKLLS TVAQAVKGQG TICWVDCGDA ESRKLCKKMK 100
    VDLSAKDKKV ELFHYQDGAF HTEYNRAVTF KSIVAFLKDP KGPPLWEEDP 150
    GAKDVVHIDN EKDFRRLLKK EEKPILMMFY APWCSVCKRI MPHFQKAATQ 200
    LRGQFVLAGM NVYPSEFENI KEEYSVRGYP TICYFEKGRF LFQYDSYGST 250
    AEDIVEWLKN PQPPQPQVPE TPWADEGGSV YHLSDEDFDQ FVKEHSSVLV 300
    MFHAPWCGHC KKMKPEFESA AEVLHGEGDS SGVLAAVDAT VNKALAERFH 350
    IAEFPTLKYF KNGEKYAVPA LRTKKSFIEW MRNPESPPPP DPAWEEQQTS 400
    VLHLSGDNFR ETLKRKKHAL VMFYAPWCPH CKKAIPHFTA AADAFKDDRK 450
    IACAAIDCVK ENNKDLCQQE AVKAYPTFHY YHYGKFVEKY DTNPTELGFT 500
    SFIRTLREGD HERLGKKKEE L 521
    Length:521
    Mass (Da):59,673
    Last modified:March 7, 2006 - v1
    Checksum:iA05A85EB4EEA2BEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112593 mRNA. Translation: AAI12594.1.
    RefSeqiNP_001039556.1. NM_001046091.2.
    UniGeneiBt.6804.

    Genome annotation databases

    EnsembliENSBTAT00000025128; ENSBTAP00000025128; ENSBTAG00000018877.
    GeneIDi511603.
    KEGGibta:511603.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112593 mRNA. Translation: AAI12594.1 .
    RefSeqi NP_001039556.1. NM_001046091.2.
    UniGenei Bt.6804.

    3D structure databases

    ProteinModelPortali Q2KIL5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000025128.

    Proteomic databases

    PRIDEi Q2KIL5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000025128 ; ENSBTAP00000025128 ; ENSBTAG00000018877 .
    GeneIDi 511603.
    KEGGi bta:511603.

    Organism-specific databases

    CTDi 10954.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00730000110455.
    HOGENOMi HOG000039967.
    HOVERGENi HBG053547.
    InParanoidi Q2KIL5.
    KOi K09583.
    OMAi YYHYGKF.
    OrthoDBi EOG74TWZ6.
    TreeFami TF106379.

    Enzyme and pathway databases

    Reactomei REACT_211201. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 20870009.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 3 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Testis.

    Entry informationi

    Entry nameiPDIA5_BOVIN
    AccessioniPrimary (citable) accession number: Q2KIL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3