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Q2KIL5 (PDIA5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein disulfide-isomerase A5
EC=5.3.4.1
Gene names
Name:PDIA5
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 3 thioredoxin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 521496Protein disulfide-isomerase A5
PRO_0000244882

Regions

Domain136 – 263128Thioredoxin 1
Domain274 – 386113Thioredoxin 2
Domain387 – 508122Thioredoxin 3
Motif518 – 5214Prevents secretion from ER Potential
Compositional bias387 – 3926Poly-Pro

Amino acid modifications

Disulfide bond184 ↔ 187Redox-active By similarity
Disulfide bond307 ↔ 310Redox-active By similarity
Disulfide bond428 ↔ 431Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KIL5 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: A05A85EB4EEA2BEA

FASTA52159,673
        10         20         30         40         50         60 
MARVVPAWLL LPLAVWVVLP TWLSSAKFSS LIERISDPKD LKKLLRTRNN VLVLYSKSEA 

        70         80         90        100        110        120 
AAESHLKLLS TVAQAVKGQG TICWVDCGDA ESRKLCKKMK VDLSAKDKKV ELFHYQDGAF 

       130        140        150        160        170        180 
HTEYNRAVTF KSIVAFLKDP KGPPLWEEDP GAKDVVHIDN EKDFRRLLKK EEKPILMMFY 

       190        200        210        220        230        240 
APWCSVCKRI MPHFQKAATQ LRGQFVLAGM NVYPSEFENI KEEYSVRGYP TICYFEKGRF 

       250        260        270        280        290        300 
LFQYDSYGST AEDIVEWLKN PQPPQPQVPE TPWADEGGSV YHLSDEDFDQ FVKEHSSVLV 

       310        320        330        340        350        360 
MFHAPWCGHC KKMKPEFESA AEVLHGEGDS SGVLAAVDAT VNKALAERFH IAEFPTLKYF 

       370        380        390        400        410        420 
KNGEKYAVPA LRTKKSFIEW MRNPESPPPP DPAWEEQQTS VLHLSGDNFR ETLKRKKHAL 

       430        440        450        460        470        480 
VMFYAPWCPH CKKAIPHFTA AADAFKDDRK IACAAIDCVK ENNKDLCQQE AVKAYPTFHY 

       490        500        510        520 
YHYGKFVEKY DTNPTELGFT SFIRTLREGD HERLGKKKEE L

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC112593 mRNA. Translation: AAI12594.1.
IPIIPI00717336.
RefSeqNP_001039556.1. NM_001046091.2.
UniGeneBt.6804.

3D structure databases

ProteinModelPortalQ2KIL5.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000025128.

Proteomic databases

PRIDEQ2KIL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000025128; ENSBTAP00000025128; ENSBTAG00000018877.
GeneID511603.
KEGGbta:511603.

Organism-specific databases

CTD10954.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00700000104354.
HOGENOMHOG000039967.
HOVERGENHBG053547.
InParanoidQ2KIL5.
KOK09583.
OMALAGMNVY.
OrthoDBEOG49KFQF.

Family and domain databases

Gene3D3.40.30.10. 3 hits.
InterProIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 3 hits.
[Graphical view]
PRINTSPR00421. THIOREDOXIN.
SUPFAMSSF52833. Thiordxn-like_fd. 4 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870009.

Entry information

Entry namePDIA5_BOVIN
AccessionPrimary (citable) accession number: Q2KIL5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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