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Protein

Histidine protein methyltransferase 1 homolog

Gene

METTL18

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable histidine methyltransferase.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 homolog
Alternative name(s):
Methyltransferase-like protein 18 (EC:2.1.1.-)
Gene namesi
Name:METTL18
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:31405 METTL18

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471981 – 373Histidine protein methyltransferase 1 homologAdd BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KIJ2
PRIDEiQ2KIJ2

Expressioni

Gene expression databases

BgeeiENSBTAG00000021671

Interactioni

Subunit structurei

Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028878

Structurei

3D structure databases

ProteinModelPortaliQ2KIJ2
SMRiQ2KIJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2920 Eukaryota
ENOG4111NE8 LUCA
GeneTreeiENSGT00390000000464
HOVERGENiHBG053309
InParanoidiQ2KIJ2
OMAiEWSEFCK
OrthoDBiEOG091G0J2W
TreeFamiTF320884

Family and domain databases

InterProiView protein in InterPro
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits

Sequencei

Sequence statusi: Complete.

Q2KIJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFQFNFTIE DHLEDELTSL GDGALALHSS KESLVSERQK GTHRDKKCST
60 70 80 90 100
EQSDLLQDHL WEHKSERNEA PSQDPDSSFG AANSSSNLEP HEEKPCLKVA
110 120 130 140 150
KEHAVPKDLK KVLENKVTET LPGLQHVNIS IMKTTLLKEN FPGENIISKS
160 170 180 190 200
FSSHSDLISG VYEGGLKIWE CTFDLLAYLT KAKVKFAGKK VLDLGCGSGL
210 220 230 240 250
LGIMALKGGA KEIHFQDYNS VVIDEVTLPN VVANSTLEDE ENDVNEPDVK
260 270 280 290 300
RLRRSTVAQE LCKCRFFSGE WSEFCKLVLS SEKLFEKYDL ILTSETIYNP
310 320 330 340 350
DYYVPLHQTF LRLLDKNGQV LLASKVHYFG VGGGTHLFQK FVEERNVFET
360 370
RTLEIIDEGL KRCLIEMTFK YPT
Length:373
Mass (Da):42,101
Last modified:March 7, 2006 - v1
Checksum:iE44319A234B0D235
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112618 mRNA Translation: AAI12619.1
RefSeqiNP_001073825.1, NM_001080356.2
XP_005216978.1, XM_005216921.1
XP_005216979.1, XM_005216922.3
UniGeneiBt.22463

Genome annotation databases

EnsembliENSBTAT00000028878; ENSBTAP00000028878; ENSBTAG00000021671
GeneIDi783955
KEGGibta:783955

Similar proteinsi

Entry informationi

Entry nameiMET18_BOVIN
AccessioniPrimary (citable) accession number: Q2KIJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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