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Protein

Peroxisomal membrane protein PEX16

Gene

PEX16

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX16
Alternative name(s):
Peroxin-16
Peroxisomal biogenesis factor 16
Gene namesi
Name:PEX16
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484CytoplasmicSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Topological domaini106 – 1105PeroxisomalSequence analysis
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Topological domaini132 – 328197CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Peroxisomal membrane protein PEX16PRO_0000366960Add
BLAST

Proteomic databases

PaxDbiQ2KII7.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004065.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 8116Required for peroxisomal locationBy similarityAdd
BLAST
Regioni213 – 328116Interaction with PEX19By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peroxin-16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4546. Eukaryota.
ENOG4111GEA. LUCA.
GeneTreeiENSGT00390000017790.
HOGENOMiHOG000008062.
HOVERGENiHBG053572.
InParanoidiQ2KII7.
KOiK13335.
OMAiTMPRTGM.
OrthoDBiEOG7XWPNZ.
TreeFamiTF324139.

Family and domain databases

InterProiIPR013919. Pex16.
[Graphical view]
PfamiPF08610. Pex16. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2KII7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKLRLLGLR YQEYVTRHPA ATAQLETAVR GLSYLLAGRF ADSHELSELV
60 70 80 90 100
YSASNLLVLL NDGILRKELR KKLPMSLSQQ RLLTWLSVLE CVEVFMEMGA
110 120 130 140 150
TKVWGEVGRW LVIALIQLAK AVLRMFLLIW FKAGLQTSPP IVPLDREIQA
160 170 180 190 200
QSRDGDHSSG SQEQSYVGKR SNRVVRTLQN TPSLHSRHWG APQQREELGV
210 220 230 240 250
APTPLGLQET IAESLHIARP LLHLLSLGLW GQRSWTPWLL SGVVDVTSLS
260 270 280 290 300
LLSDRKGLTR RERLELRRRT ILLLYYLLRS PFYDRFSEAK ILFLLQLLAD
310 320
HVPGIGLVTR PLMDYLPNWQ KIYFYSWG
Note: No experimental confirmation available. Derived from EST data.
Length:328
Mass (Da):37,574
Last modified:March 24, 2009 - v2
Checksum:i9B6347E9CEE4D49D
GO
Isoform 2 (identifier: Q2KII7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-146: Missing.

Show »
Length:302
Mass (Da):34,609
Checksum:i9CDEA2D4ECEFDDB6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 14626Missing in isoform 2. 1 PublicationVSP_036594Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03090303 Genomic DNA. No translation available.
BC112623 mRNA. Translation: AAI12624.1.
RefSeqiNP_001068917.1. NM_001075449.2. [Q2KII7-2]
XP_005216504.1. XM_005216447.3. [Q2KII7-1]
UniGeneiBt.45496.

Genome annotation databases

EnsembliENSBTAT00000004065; ENSBTAP00000004065; ENSBTAG00000003126. [Q2KII7-1]
GeneIDi510447.
KEGGibta:510447.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03090303 Genomic DNA. No translation available.
BC112623 mRNA. Translation: AAI12624.1.
RefSeqiNP_001068917.1. NM_001075449.2. [Q2KII7-2]
XP_005216504.1. XM_005216447.3. [Q2KII7-1]
UniGeneiBt.45496.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004065.

Proteomic databases

PaxDbiQ2KII7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004065; ENSBTAP00000004065; ENSBTAG00000003126. [Q2KII7-1]
GeneIDi510447.
KEGGibta:510447.

Organism-specific databases

CTDi9409.

Phylogenomic databases

eggNOGiKOG4546. Eukaryota.
ENOG4111GEA. LUCA.
GeneTreeiENSGT00390000017790.
HOGENOMiHOG000008062.
HOVERGENiHBG053572.
InParanoidiQ2KII7.
KOiK13335.
OMAiTMPRTGM.
OrthoDBiEOG7XWPNZ.
TreeFamiTF324139.

Miscellaneous databases

NextBioi20869446.

Family and domain databases

InterProiIPR013919. Pex16.
[Graphical view]
PfamiPF08610. Pex16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiPEX16_BOVIN
AccessioniPrimary (citable) accession number: Q2KII7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 13, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.