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Protein

Neuroguidin

Gene

NGDN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroguidin
Alternative name(s):
EIF4E-binding protein
Gene namesi
Name:NGDN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:32059 NGDN

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002692462 – 315NeuroguidinAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei214PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KII6
PRIDEiQ2KII6

Expressioni

Gene expression databases

BgeeiENSBTAG00000009595

Interactioni

Subunit structurei

Interacts with CPEB1 and EIF4E.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012628

Structurei

3D structure databases

SMRiQ2KII6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 174Necessary for interaction with EIF4EBy similarityAdd BLAST134

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 42Sequence analysisAdd BLAST38
Coiled coili181 – 205Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi312 – 315Poly-Arg4

Sequence similaritiesi

Belongs to the SAS10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3117 Eukaryota
ENOG4111F0Z LUCA
GeneTreeiENSGT00500000044922
HOGENOMiHOG000013129
HOVERGENiHBG082025
InParanoidiQ2KII6
KOiK14765
OMAiHRINYEE
OrthoDBiEOG091G0I9S
TreeFamiTF313713

Family and domain databases

InterProiView protein in InterPro
IPR007146 Sas10/Utp3/C1D
PfamiView protein in Pfam
PF04000 Sas10_Utp3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KII6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEVLESD LPNAVALLKN LQEQVMAVTA QVQTLTKKVQ AKAYPTEKGL
60 70 80 90 100
SLLEVKDQLL LMYLMDLSHL ILDKASGGSL QGHPAVLRLV EIRTVLEKLR
110 120 130 140 150
PLDQKLKYQI DKLVKTAVTG SLSENDPLRF KPHPSNMMSK LSSEDEEEDE
160 170 180 190 200
AEEGQSGASG KKSGKGTAKK YVPPRLVPVH YDETEAEREK KRLERAKRRA
210 220 230 240 250
LSSSVIRELK EQYSDAPEEI RDARHPHVTR QSQEDQHRIN YEESMMVRLS
260 270 280 290 300
VSKREKGRRK RANVMSSQLH SLTHFSDISA LTGGTPHLDE DQNPTKKRKK
310
IPKKGRKKKG FRRRR
Length:315
Mass (Da):35,766
Last modified:March 7, 2006 - v1
Checksum:iA81FB585EE7449BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112624 mRNA Translation: AAI12625.1
RefSeqiNP_001039924.1, NM_001046459.1
UniGeneiBt.9759

Genome annotation databases

EnsembliENSBTAT00000012628; ENSBTAP00000012628; ENSBTAG00000009595
GeneIDi539602
KEGGibta:539602

Similar proteinsi

Entry informationi

Entry nameiNGDN_BOVIN
AccessioniPrimary (citable) accession number: Q2KII6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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