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Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

ATF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Gene namesi
Name:ATF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852111 – 181Cyclic AMP-dependent transcription factor ATF-3Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei162PhosphothreonineBy similarity1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ2KII1.
PRIDEiQ2KII1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008545.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011265.

Structurei

3D structure databases

ProteinModelPortaliQ2KII1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 149bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 110Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni114 – 142Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiQ2KII1.
KOiK09032.
OMAiLVYMLNL.
OrthoDBiEOG091G0M4N.
TreeFamiTF326301.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR029812. ATF3.
IPR004827. bZIP.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF39. PTHR23351:SF39. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KII1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLQHPGQVS ASEVSASAFV PCLSPPGSLV FEDFANLTPF VKEELRLAIQ
60 70 80 90 100
SKHLCHRMSS ALDSVTVSGR PLEMSVTKAE VAPEEDERKK RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
Length:181
Mass (Da):20,567
Last modified:March 7, 2006 - v1
Checksum:i95A10B4CFA89AD88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112629 mRNA. Translation: AAI12630.1.
RefSeqiNP_001039658.1. NM_001046193.2.
XP_010811857.1. XM_010813555.2.
UniGeneiBt.18533.

Genome annotation databases

EnsembliENSBTAT00000011265; ENSBTAP00000011265; ENSBTAG00000008545.
GeneIDi515266.
KEGGibta:515266.

Entry informationi

Entry nameiATF3_BOVIN
AccessioniPrimary (citable) accession number: Q2KII1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 7, 2006
Last modified: August 30, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families