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Q2KIG0 (ETFD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Short name=ETF-QO
Short name=ETF-ubiquinone oxidoreductase
EC=1.5.5.1
Alternative name(s):
Electron-transferring-flavoprotein dehydrogenase
Short name=ETF dehydrogenase
Gene names
Name:ETFDH
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accepts electrons from ETF and reduces ubiquinone By similarity.

Catalytic activity

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactor

Binds 1 4Fe-4S cluster By similarity.

FAD By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Mitochondrion inner membrane By similarity.

Sequence similarities

Belongs to the ETF-QO/fixC family.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion Potential
Chain34 – 617584Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
PRO_0000285209

Regions

Intramembrane109 – 13022 By similarity
Intramembrane428 – 44720 By similarity
Domain577 – 606304Fe-4S ferredoxin-type
Nucleotide binding71 – 8515FAD Potential

Sites

Metal binding5611Iron-sulfur (4Fe-4S) Potential
Metal binding5861Iron-sulfur (4Fe-4S) Potential
Metal binding5891Iron-sulfur (4Fe-4S) Potential
Metal binding5921Iron-sulfur (4Fe-4S) Potential
Binding site3051Ubiquinone; via carbonyl oxygen By similarity
Binding site3061Ubiquinone; via amide nitrogen By similarity

Amino acid modifications

Modified residue961N6-acetyllysine By similarity
Modified residue1531N6-acetyllysine By similarity
Modified residue2231N6-acetyllysine By similarity
Modified residue3441N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KIG0 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 3ABDAE292A4C4920

FASTA61768,612
        10         20         30         40         50         60 
MQVLLARLAC PVYQCFHAIK IKKNYLPLCA TRWSSTSVVP RITTHYTVYP RDQDKRWEGV 

        70         80         90        100        110        120 
NMERFAEEAD VVIVGAGPAG LSAAARLKQL AAQHEKDIRV CLVEKAAQIG AHTLSGACLD 

       130        140        150        160        170        180 
PRALQELFPD WKEKGAPLNT PVTEDRFGIL TEKYRIPVPI LPGLPMNNHG NYIVRLGHLV 

       190        200        210        220        230        240 
SWMGEQAEAL GVEVYPGYAA AEVLFHEDGS VKGIATNDVG IQKDGAPKTT FERGLELHAK 

       250        260        270        280        290        300 
VTIFAEGCHG HLAKQLYRKF DLRANCEPQT YGIGLKELWV IDEKKWKPGR VDHTVGWPLD 

       310        320        330        340        350        360 
RHTYGGSFLY HLNEGEPLVA LGFVVGLDYQ NPYLSPFREF QRWKHHPSIQ PTLEGGKRIA 

       370        380        390        400        410        420 
YGARALNEGG LQCIPKLTFP GGLLIGCSPG FMNVPKIKGT HTAMKSGILA AESIFNQLTN 

       430        440        450        460        470        480 
ENLQSKTIGL DVTEYEDNLK KSWVWKELYA VRNIRPSCHS ILGVYGGMIY TGIFYWIFRG 

       490        500        510        520        530        540 
MEPWTLKHKG SDSDKLKPAK DCTPIEYPKP DGQISFDLLS SVALSGTNHE HDQPAHLTLK 

       550        560        570        580        590        600 
DDSVPVNRNL SIYDGPEQRF CPAGVYEFVP VEQGDGFRLQ INAQNCVHCK TCDIKDPSQN 

       610 
INWVVPEGGG GPAYNGM

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC112652 mRNA. Translation: AAI12653.1.
IPIIPI00694705.
RefSeqNP_001070598.1. NM_001077130.1.
UniGeneBt.42330.

3D structure databases

ProteinModelPortalQ2KIG0.
SMRQ2KIG0. Positions 39-617.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2KIG0.

Proteomic databases

PRIDEQ2KIG0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000022178; ENSBTAP00000022178; ENSBTAG00000016679.
GeneID768074.
KEGGbta:768074.

Organism-specific databases

CTD2110.

Phylogenomic databases

eggNOGmaNOG11897.
GeneTreeENSGT00390000010773.
HOVERGENHBG005615.
InParanoidQ2KIG0.
OMALKNSWVW.
OrthoDBEOG42RD6T.
PhylomeDBQ2KIG0.

Family and domain databases

InterProIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase.
[Graphical view]
KOK00311.
PfamPF05187. ETF_QO. 1 hit.
[Graphical view]
PROSITEPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameETFD_BOVIN
AccessionPrimary (citable) accession number: Q2KIG0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 7, 2006
Last modified: November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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