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Protein

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene

ETFDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts electrons from ETF and reduces ubiquinone.By similarity

Catalytic activityi

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei305 – 3051Ubiquinone; via carbonyl oxygenBy similarity
Binding sitei306 – 3061Ubiquinone; via amide nitrogenBy similarity
Metal bindingi561 – 5611Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi586 – 5861Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi589 – 5891Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi592 – 5921Iron-sulfur (4Fe-4S)Sequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 8515FADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Ubiquinone

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (EC:1.5.5.1)
Short name:
ETF-QO
Short name:
ETF-ubiquinone oxidoreductase
Alternative name(s):
Electron-transferring-flavoprotein dehydrogenase
Short name:
ETF dehydrogenase
Gene namesi
Name:ETFDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei109 – 13022By similarityAdd
BLAST
Intramembranei428 – 44720By similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence analysisAdd
BLAST
Chaini34 – 617584Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialPRO_0000285209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961N6-acetyllysineBy similarity
Modified residuei132 – 1321N6-acetyllysineBy similarity
Modified residuei223 – 2231N6-acetyllysineBy similarity
Modified residuei357 – 3571N6-acetyllysineBy similarity
Modified residuei551 – 5511PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KIG0.
PeptideAtlasiQ2KIG0.
PRIDEiQ2KIG0.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022178.

Structurei

3D structure databases

ProteinModelPortaliQ2KIG0.
SMRiQ2KIG0. Positions 39-617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini577 – 606304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.Curated
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
GeneTreeiENSGT00390000010773.
HOGENOMiHOG000259450.
HOVERGENiHBG005615.
InParanoidiQ2KIG0.
KOiK00311.
OMAiLRGMEPW.
OrthoDBiEOG7WX07W.
TreeFamiTF105687.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLLARLAC PVYQCFHAIK IKKNYLPLCA TRWSSTSVVP RITTHYTVYP
60 70 80 90 100
RDQDKRWEGV NMERFAEEAD VVIVGAGPAG LSAAARLKQL AAQHEKDIRV
110 120 130 140 150
CLVEKAAQIG AHTLSGACLD PRALQELFPD WKEKGAPLNT PVTEDRFGIL
160 170 180 190 200
TEKYRIPVPI LPGLPMNNHG NYIVRLGHLV SWMGEQAEAL GVEVYPGYAA
210 220 230 240 250
AEVLFHEDGS VKGIATNDVG IQKDGAPKTT FERGLELHAK VTIFAEGCHG
260 270 280 290 300
HLAKQLYRKF DLRANCEPQT YGIGLKELWV IDEKKWKPGR VDHTVGWPLD
310 320 330 340 350
RHTYGGSFLY HLNEGEPLVA LGFVVGLDYQ NPYLSPFREF QRWKHHPSIQ
360 370 380 390 400
PTLEGGKRIA YGARALNEGG LQCIPKLTFP GGLLIGCSPG FMNVPKIKGT
410 420 430 440 450
HTAMKSGILA AESIFNQLTN ENLQSKTIGL DVTEYEDNLK KSWVWKELYA
460 470 480 490 500
VRNIRPSCHS ILGVYGGMIY TGIFYWIFRG MEPWTLKHKG SDSDKLKPAK
510 520 530 540 550
DCTPIEYPKP DGQISFDLLS SVALSGTNHE HDQPAHLTLK DDSVPVNRNL
560 570 580 590 600
SIYDGPEQRF CPAGVYEFVP VEQGDGFRLQ INAQNCVHCK TCDIKDPSQN
610
INWVVPEGGG GPAYNGM
Length:617
Mass (Da):68,612
Last modified:March 7, 2006 - v1
Checksum:i3ABDAE292A4C4920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112652 mRNA. Translation: AAI12653.1.
RefSeqiNP_001070598.1. NM_001077130.2.
UniGeneiBt.42330.

Genome annotation databases

EnsembliENSBTAT00000022178; ENSBTAP00000022178; ENSBTAG00000016679.
GeneIDi768074.
KEGGibta:768074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112652 mRNA. Translation: AAI12653.1.
RefSeqiNP_001070598.1. NM_001077130.2.
UniGeneiBt.42330.

3D structure databases

ProteinModelPortaliQ2KIG0.
SMRiQ2KIG0. Positions 39-617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022178.

Proteomic databases

PaxDbiQ2KIG0.
PeptideAtlasiQ2KIG0.
PRIDEiQ2KIG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022178; ENSBTAP00000022178; ENSBTAG00000016679.
GeneIDi768074.
KEGGibta:768074.

Organism-specific databases

CTDi2110.

Phylogenomic databases

eggNOGiKOG2415. Eukaryota.
COG0644. LUCA.
GeneTreeiENSGT00390000010773.
HOGENOMiHOG000259450.
HOVERGENiHBG005615.
InParanoidiQ2KIG0.
KOiK00311.
OMAiLRGMEPW.
OrthoDBiEOG7WX07W.
TreeFamiTF105687.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiETFD_BOVIN
AccessioniPrimary (citable) accession number: Q2KIG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 7, 2006
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.