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Protein

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene

ETFDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts electrons from ETF and reduces ubiquinone.By similarity

Catalytic activityi

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei305Ubiquinone; via carbonyl oxygenBy similarity1
Binding sitei306Ubiquinone; via amide nitrogenBy similarity1
Metal bindingi561Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi586Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi589Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi592Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 85FADSequence analysisAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
Ligand4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Ubiquinone

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (EC:1.5.5.1)
Short name:
ETF-QO
Short name:
ETF-ubiquinone oxidoreductase
Alternative name(s):
Electron-transferring-flavoprotein dehydrogenase
Short name:
ETF dehydrogenase
Gene namesi
Name:ETFDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:28621 ETFDH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Intramembranei109 – 130By similarityAdd BLAST22
Intramembranei428 – 447By similarityAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000028520934 – 617Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96N6-acetyllysineBy similarity1
Modified residuei132N6-acetyllysineBy similarity1
Modified residuei223N6-acetyllysineBy similarity1
Modified residuei357N6-acetyllysineBy similarity1
Modified residuei551PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2KIG0
PeptideAtlasiQ2KIG0
PRIDEiQ2KIG0

Expressioni

Gene expression databases

BgeeiENSBTAG00000016679

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022178

Structurei

3D structure databases

ProteinModelPortaliQ2KIG0
SMRiQ2KIG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini577 – 6064Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2415 Eukaryota
COG0644 LUCA
GeneTreeiENSGT00390000010773
HOGENOMiHOG000259450
HOVERGENiHBG005615
InParanoidiQ2KIG0
KOiK00311
OMAiVPRITTH
OrthoDBiEOG091G03C7
TreeFamiTF105687

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR036188 FAD/NAD-bd_sf
SUPFAMiSSF51905 SSF51905, 2 hits
PROSITEiView protein in PROSITE
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KIG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLLARLAC PVYQCFHAIK IKKNYLPLCA TRWSSTSVVP RITTHYTVYP
60 70 80 90 100
RDQDKRWEGV NMERFAEEAD VVIVGAGPAG LSAAARLKQL AAQHEKDIRV
110 120 130 140 150
CLVEKAAQIG AHTLSGACLD PRALQELFPD WKEKGAPLNT PVTEDRFGIL
160 170 180 190 200
TEKYRIPVPI LPGLPMNNHG NYIVRLGHLV SWMGEQAEAL GVEVYPGYAA
210 220 230 240 250
AEVLFHEDGS VKGIATNDVG IQKDGAPKTT FERGLELHAK VTIFAEGCHG
260 270 280 290 300
HLAKQLYRKF DLRANCEPQT YGIGLKELWV IDEKKWKPGR VDHTVGWPLD
310 320 330 340 350
RHTYGGSFLY HLNEGEPLVA LGFVVGLDYQ NPYLSPFREF QRWKHHPSIQ
360 370 380 390 400
PTLEGGKRIA YGARALNEGG LQCIPKLTFP GGLLIGCSPG FMNVPKIKGT
410 420 430 440 450
HTAMKSGILA AESIFNQLTN ENLQSKTIGL DVTEYEDNLK KSWVWKELYA
460 470 480 490 500
VRNIRPSCHS ILGVYGGMIY TGIFYWIFRG MEPWTLKHKG SDSDKLKPAK
510 520 530 540 550
DCTPIEYPKP DGQISFDLLS SVALSGTNHE HDQPAHLTLK DDSVPVNRNL
560 570 580 590 600
SIYDGPEQRF CPAGVYEFVP VEQGDGFRLQ INAQNCVHCK TCDIKDPSQN
610
INWVVPEGGG GPAYNGM
Length:617
Mass (Da):68,612
Last modified:March 7, 2006 - v1
Checksum:i3ABDAE292A4C4920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112652 mRNA Translation: AAI12653.1
RefSeqiNP_001070598.1, NM_001077130.2
UniGeneiBt.42330

Genome annotation databases

EnsembliENSBTAT00000022178; ENSBTAP00000022178; ENSBTAG00000016679
GeneIDi768074
KEGGibta:768074

Similar proteinsi

Entry informationi

Entry nameiETFD_BOVIN
AccessioniPrimary (citable) accession number: Q2KIG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health