Reviewed, UniProtKB/Swiss-Prot Q2KIC5 (ITPA_BOVIN)

Names and origin

Protein names

Recommended name:
    Inosine triphosphate pyrophosphatase
      Short name=ITPase
      Short name=Inosine triphosphatase
    EC=3.6.1.19

Gene names

Name:

ITPA

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes ITP and dITP to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. May be the major enzyme responsible for regulating ITP concentration in cells By similarity.
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
PTM	Acetylation
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 208	207	Inosine triphosphate pyrophosphatase		PRO_0000306869
Sites
	Metal binding	44	1	Magnesium By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KIC5-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: F49F922F60A8822B	FASTA	208	23,061
	10 20 30 40 50 60 MAASLAGKKI VFVTGNAKKL EEVIQILGDK FPCTLVAQKI DLPEYQGEPD EISIRKCQEA 70 80 90 100 110 120 ARQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLEGFQDK SAYALCTFAF 130 140 150 160 170 180 STGDPNEPVR LFRGRTMGRI VVPRGCRDFG WDPCFQPDGY EQTYAEMPKA EKNTISHRFR 190 200 ALLALQEYFS SLTPGVGDDH PSWGSGEG

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC112688 mRNA. Translation: AAI12689.1.
IPI	IPI00702859.
RefSeq	NP_001069750.1.
UniGene	Bt.53005
3D structure databases
SMR	Q2KIC5. Positions 1-192.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000013776. Bos taurus. [Contig view]
GeneID	613653.
KEGG	bta:613653.
Phylogenomic databases
HOVERGEN	Q2KIC5.
Enzyme and pathway databases
BRENDA	3.6.1.19. 251.
Family and domain databases
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ITPA_BOVIN

Accession

Primary (citable) accession number: Q2KIC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)