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Protein

ETS translocation variant 1

Gene

ETV1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi335 – 415ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 1
Gene namesi
Name:ETV1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:28628 ETV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871331 – 477ETS translocation variant 1Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94PhosphoserineBy similarity1
Modified residuei191Phosphoserine; by RPS6KA1 and RPS6KA5By similarity1
Modified residuei216Phosphoserine; by RPS6KA1 and RPS6KA5By similarity1
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated.By similarity
Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ2KIC2
PRIDEiQ2KIC2

Expressioni

Gene expression databases

BgeeiENSBTAG00000015981

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021259

Structurei

3D structure databases

ProteinModelPortaliQ2KIC2
SMRiQ2KIC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000230986
HOVERGENiHBG000231
InParanoidiQ2KIC2
KOiK09431
OMAiNRTEGCM
OrthoDBiEOG091G04YU
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR006715 ETS_PEA3_N
IPR032928 ETS_V1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF210 PTHR11849:SF210, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF04621 ETS_PEA3_N, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KIC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGFYDQQVP YMVTNNQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL
60 70 80 90 100
SQLQETWLAE AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG
110 120 130 140 150
SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH
160 170 180 190 200
ASPNSAHTSK PDRAFPAHLP PSQPIQDSSY PMDHRFRRQL SEPCNSFPPL
210 220 230 240 250
PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT MVGGAASQSF
260 270 280 290 300
PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLTHPSRTE GCMFEKGPRQ
310 320 330 340 350
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN
360 370 380 390 400
SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG
410 420 430 440 450
IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL
460 470
SHFDESMAYM PEGGCCNPHP YNEGYVY
Length:477
Mass (Da):55,129
Last modified:March 7, 2006 - v1
Checksum:i5F3AD6E355E266A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112692 mRNA Translation: AAI12693.1
RefSeqiNP_001039957.1, NM_001046492.2
XP_005205260.1, XM_005205203.3
UniGeneiBt.87334

Genome annotation databases

EnsembliENSBTAT00000021259; ENSBTAP00000021259; ENSBTAG00000015981
GeneIDi540846
KEGGibta:540846

Similar proteinsi

Entry informationi

Entry nameiETV1_BOVIN
AccessioniPrimary (citable) accession number: Q2KIC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome