Q2KIB9 (RPP29_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p29
EC=3.1.26.5

Gene names

Name:	POP4
Synonyms:	RPP29

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5 By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA cleavage Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolar ribonuclease P complex Inferred from electronic annotation. Source: InterPro ribonuclease MRP complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Ribonuclease P protein subunit p29		PRO_0000236680
Amino acid modifications
	Modified residue	10	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KIB9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 0F9F42C93BD1D627	FASTA	220	25,524
	10 20 30 40 50 60 MTSVVYHAFS QKEAKELDVQ HSGAQRAEAF VRAFLKRSMP RMSQQALEDH LQRKAVVLEY 70 80 90 100 110 120 FTHRKQKEKR KKSKGLSAKQ RRELRLFDIK PEQQRYSLFL PLHELWKQYI RDLCNGLKPD 130 140 150 160 170 180 TQPQMIQAKL LKADLHGAIV SVTKSKCPSY VGVTGILLQE TKHVFKIITK EDRLKVIPKL 190 200 210 220 NCVFTVEIDG FISYIYGSKF QLRSSERSAK KFKAKGTIDL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC112695 mRNA. Translation: AAI12696.1.
IPI	IPI00704290.
RefSeq	NP_001106753.1. NM_001113282.2.
UniGene	Bt.21490.
3D structure databases
ProteinModelPortal	Q2KIB9.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000002876.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	614870.
KEGG	bta:614870.
Organism-specific databases
CTD	10775.
Phylogenomic databases
eggNOG	NOG255667.
HOGENOM	HOG000007746.
HOVERGEN	HBG002676.
InParanoid	Q2KIB9.
KO	K03538.
OrthoDB	EOG4TXBT7.
Gene expression databases
ArrayExpress	Q2KIB9.
Family and domain databases
Gene3D	2.30.30.210. 1 hit.
InterPro	IPR002730. RNase_P/MRP_p29. IPR016848. RNase_P/MRP_p29-subunit. IPR023534. Rof/RNase_P-like. [Graphical view]
Pfam	PF01868. UPF0086. 1 hit. [Graphical view]
PIRSF	PIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMART	SM00538. POP4. 1 hit. [Graphical view]
SUPFAM	SSF101744. RNase_P_Rpp29. 1 hit.
ProtoNet	Search...
Other
NextBio	20899328.

Entry information

Entry name

RPP29_BOVIN

Accession

Primary (citable) accession number: Q2KIB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	March 7, 2006
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program